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Raul Mostoslavsky, M.D., Ph.D.

Concepts (499)

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Concepts are derived automatically from a person's publications.
Concepts are listed by decreasing relevance which is based on many factors, including how many publications the person wrote about that topic, how long ago those publications were written, and how many publications other people have written on that same topic.
Name Number of Publications Most Recent Publication Publications by All Authors Concept Score Why?
Sirtuins60202332013.300 Why?
DNA Repair14202220392.110 Why?
Chromatin16202229392.010 Why?
Glycolysis820228281.460 Why?
Histones14202125831.430 Why?
Genomic Instability1020217041.400 Why?
Epigenesis, Genetic12202437581.230 Why?
DNA Damage13202224421.230 Why?
Sirtuin 11720142471.000 Why?
Acetylation18201910620.960 Why?
Chromatin Assembly and Disassembly620216330.950 Why?
Cell Nucleus5202029090.930 Why?
Energy Metabolism6201628690.860 Why?
Glutamine320235760.840 Why?
Acetyl Coenzyme A32017750.820 Why?
Glutathione Transferase120245650.800 Why?
Longevity8201410500.780 Why?
Aging13202386410.770 Why?
DNA Repair Enzymes120213450.690 Why?
Neoplasms142024220660.680 Why?
Cell Transformation, Neoplastic4202228230.660 Why?
Animals9320241679400.660 Why?
Open Reading Frames120218140.620 Why?
DNA Replication4202014120.610 Why?
DNA, Ribosomal120182850.570 Why?
Cytosine220152120.570 Why?
Disease220136710.570 Why?
Hepatocyte Nuclear Factor 3-alpha120171650.560 Why?
RNA Polymerase II220215390.530 Why?
Pancreatic Neoplasms4202453330.510 Why?
Neoplastic Stem Cells2202113470.500 Why?
Mitosis2202111930.500 Why?
Mice642024812160.500 Why?
Embryonic Stem Cells5201812620.490 Why?
Sirtuin 232014960.490 Why?
Histone Deacetylases420137180.480 Why?
Germ-Free Life120141870.470 Why?
Immunoprecipitation320138770.470 Why?
Butyrates120141690.460 Why?
Immunoglobulin kappa-Chains520071690.450 Why?
Chromatin Immunoprecipitation220138590.440 Why?
Proto-Oncogene Proteins3201544940.430 Why?
Cells120141640.430 Why?
Mice, Knockout212021143960.420 Why?
Transcription, Genetic10202175930.420 Why?
Enhancer Elements, Genetic4201713560.420 Why?
Nucleosomes220134840.410 Why?
Immune System420037950.410 Why?
Acetyltransferases120132310.390 Why?
Glucose7201743610.390 Why?
Sirtuin 322011680.390 Why?
Gene Expression Regulation122018119020.390 Why?
Tumor Microenvironment1202438260.380 Why?
Mammals5202311290.370 Why?
Dietary Fiber120147600.360 Why?
Point Mutation1201515940.350 Why?
Gene Expression Regulation, Neoplastic5202484980.340 Why?
Promoter Regions, Genetic4202157840.340 Why?
Hypoxia-Inducible Factor 1, alpha Subunit220106200.330 Why?
DNA Methylation11202443740.330 Why?
Adenosine Triphosphatases120138330.320 Why?
DNA-Binding Proteins4201595900.310 Why?
Alleles8200869000.300 Why?
Chromosomal Proteins, Non-Histone120137280.300 Why?
NAD720236100.300 Why?
Cell Differentiation62018114800.300 Why?
Humans8020247602610.300 Why?
Mitochondria6202335980.290 Why?
Proto-Oncogene Proteins c-myc420209950.290 Why?
Retina2201826350.290 Why?
Acetaminophen120115530.280 Why?
Cell Proliferation102023104340.280 Why?
RNA-Binding Proteins1201618920.280 Why?
Cell Lineage2201625250.280 Why?
Epigenomics120139360.280 Why?
Fungal Proteins120119110.270 Why?
Head and Neck Neoplasms1202128800.270 Why?
Neoplasm Metastasis3202448910.270 Why?
Ovarian Neoplasms1202248750.250 Why?
Gene Rearrangement, B-Lymphocyte, Light Chain32001180.250 Why?
5-Methylcytosine220151460.240 Why?
Genes, T-Cell Receptor12004300.240 Why?
Drosophila Proteins2201116990.240 Why?
Mice, Inbred C57BL122024220250.230 Why?
SOXB1 Transcription Factors220162860.230 Why?
Caenorhabditis elegans Proteins120118660.230 Why?
Adenocarcinoma2202463100.220 Why?
Gene Deletion3202026680.220 Why?
Mice, SCID4202126270.220 Why?
Phenotype82017165430.210 Why?
Dioxygenases220153430.210 Why?
Protein Processing, Post-Translational5201819770.210 Why?
Antibody Specificity1200410610.200 Why?
Glutamates120233910.200 Why?
Nicotinamide Phosphoribosyltransferase32012840.200 Why?
Proline120234570.200 Why?
Glucose Transporter Type 1220141860.200 Why?
B-Lymphocytes7200747390.190 Why?
Nuclear Receptor Subfamily 4, Group A, Member 112021670.190 Why?
Signal Transduction152023233630.190 Why?
Cell Line, Tumor92024169050.190 Why?
Genetic Diseases, Inborn120066010.190 Why?
Metabolism220121930.180 Why?
Fatty Acids3202118050.180 Why?
Immune Evasion120243620.180 Why?
Cell Cycle Proteins5201934480.180 Why?
Heart Diseases1201428090.180 Why?
Genes, Immunoglobulin420062870.180 Why?
Pentose Phosphate Pathway120211260.180 Why?
Pluripotent Stem Cells220187910.180 Why?
Fibronectins120247210.180 Why?
DNA4202472360.180 Why?
NF-E2-Related Factor 2120233760.170 Why?
Scavenger Receptors, Class A12020520.170 Why?
Gene Expression Regulation, Developmental6201536010.170 Why?
Transcription Factors92022121000.170 Why?
Epithelial-Mesenchymal Transition120247300.160 Why?
Insulin4201765920.160 Why?
Lymphocytes2200626120.160 Why?
Down-Regulation5202029180.160 Why?
Kinetics3202163780.160 Why?
Tumor Suppressor Proteins3201628040.160 Why?
Immediate-Early Proteins120214490.160 Why?
Adipocytes, Brown120191490.160 Why?
Glutathione120215820.150 Why?
Lipolysis120192110.150 Why?
Caloric Restriction320102950.150 Why?
PPAR gamma120214840.150 Why?
Transcriptional Elongation Factors120191660.150 Why?
Fibroblasts6201740910.150 Why?
RNA, Neoplasm120217490.150 Why?
Isocitrate Dehydrogenase120249270.150 Why?
Xenograft Model Antitumor Assays3202135840.150 Why?
HMGB Proteins12017440.150 Why?
Mice, 129 Strain220163730.150 Why?
Embryoid Bodies12018650.150 Why?
Lysine3201310020.150 Why?
Cell Line72019156260.140 Why?
Dual-Specificity Phosphatases12017700.140 Why?
Gene Knockout Techniques420128030.140 Why?
Gene Expression Regulation, Enzymologic2201211730.130 Why?
Receptors, Notch220117420.130 Why?
Mutation52024299500.130 Why?
Antibodies1200424240.130 Why?
Cell Survival2202457960.130 Why?
Fetal Death120184340.130 Why?
Metabolic Networks and Pathways120207880.130 Why?
High-Throughput Screening Assays120219430.130 Why?
Adenomatous Polyposis Coli Protein120161800.130 Why?
Models, Biological7202094680.130 Why?
Trans-Activators3201228610.130 Why?
Quinazolinones120172230.130 Why?
Diabetes Mellitus1201458840.120 Why?
Reactive Oxygen Species4202321380.120 Why?
Genes, ras220166540.120 Why?
Oxidative Stress6202331070.120 Why?
Colorectal Neoplasms1201468550.120 Why?
Neoplastic Cells, Circulating120219380.120 Why?
Tumor Necrosis Factor-alpha5201643570.120 Why?
High Mobility Group Proteins120151760.120 Why?
Gene Expression3201875920.120 Why?
Cells, Cultured82016189680.120 Why?
Octamer Transcription Factor-3120152230.120 Why?
Eye Proteins120186330.120 Why?
p300-CBP Transcription Factors220121500.110 Why?
Mixed Function Oxygenases120152650.110 Why?
Lipid Metabolism2201419020.110 Why?
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma120173810.110 Why?
Proto-Oncogene Proteins c-akt1202224490.110 Why?
Receptors, Glutamate120142290.110 Why?
X Chromosome120178150.110 Why?
Phosphatidylinositol 3-Kinases3202228660.110 Why?
T-Lymphocytes42017101830.110 Why?
Acrylamides220122600.110 Why?
Catalytic Domain120157060.110 Why?
Circadian Rhythm3201625670.110 Why?
Myocytes, Cardiac2202116560.110 Why?
Antioxidants1202116680.110 Why?
Glucose Intolerance120175790.110 Why?
Intestines1202219070.110 Why?
Oncogene Protein v-akt120121290.100 Why?
Genomic Imprinting320173300.100 Why?
Genome1202017390.100 Why?
Immunoglobulin Heavy Chains220066490.100 Why?
Teratoma120154030.100 Why?
Immunity, Innate1202430460.100 Why?
HEK293 Cells5202142640.100 Why?
S-Adenosylmethionine120132130.100 Why?
Gluconeogenesis120121850.100 Why?
Transfection3201557820.100 Why?
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization120135080.100 Why?
Bone Marrow2202029180.100 Why?
Hepatocytes2202212280.090 Why?
Methyltransferases220133730.090 Why?
Liver5201475120.090 Why?
JNK Mitogen-Activated Protein Kinases120124440.090 Why?
Oxidoreductases, N-Demethylating120111100.090 Why?
Electron Transport120112060.090 Why?
Growth and Development12010470.090 Why?
Sterol Regulatory Element Binding Protein 212010560.090 Why?
Gene Rearrangement, beta-Chain T-Cell Antigen Receptor22008940.090 Why?
Glutamate Dehydrogenase22007500.090 Why?
Citric Acid Cycle120112300.090 Why?
Pro-Opiomelanocortin120101400.090 Why?
Sterol Regulatory Element Binding Protein 1120101350.090 Why?
Recombination, Genetic2200615260.090 Why?
Cardiomegaly120125930.090 Why?
Single-Cell Analysis1202123680.090 Why?
Acetates120113220.080 Why?
Mice, Transgenic8201995310.080 Why?
Neutrophil Infiltration120123940.080 Why?
Isoenzymes1201416900.080 Why?
Adaptation, Physiological1201612970.080 Why?
Cell Respiration120102020.080 Why?
Neoplasm Transplantation1201220140.080 Why?
Molecular Sequence Data42015176280.080 Why?
Genes, T-Cell Receptor beta12008710.080 Why?
Neurogenesis120158550.080 Why?
Neurodegenerative Diseases1201710830.080 Why?
RecQ Helicases12008530.080 Why?
Mice, Inbred BALB C4201662260.080 Why?
RNA Interference2201528460.080 Why?
Base Pair Mismatch12008920.080 Why?
Diabetic Retinopathy1201712680.080 Why?
Silent Information Regulator Proteins, Saccharomyces cerevisiae12007640.070 Why?
Carbon-Carbon Double Bond Isomerases1200750.070 Why?
Enoyl-CoA Hydratase12007110.070 Why?
Gene Silencing3201715110.070 Why?
Acetyl-CoA C-Acyltransferase12007230.070 Why?
Fatty Liver120137770.070 Why?
3-Hydroxyacyl CoA Dehydrogenases12007590.070 Why?
Cluster Analysis1201426980.070 Why?
Gene Rearrangement, B-Lymphocyte120071120.070 Why?
Somatic Hypermutation, Immunoglobulin120071010.070 Why?
Exodeoxyribonucleases120081950.070 Why?
Mitochondria, Liver120071900.070 Why?
Racemases and Epimerases120071120.070 Why?
Piperidines2201216500.070 Why?
Immunoglobulin Variable Region320074190.070 Why?
Mice, Nude1201236050.070 Why?
Stomach Neoplasms1201614230.070 Why?
Amino Acid Sequence22015134560.070 Why?
Liver Neoplasms1202243170.070 Why?
Mitochondria, Muscle120071720.070 Why?
Acylation22018980.060 Why?
Adenoma1201621480.060 Why?
Homeodomain Proteins1201524140.060 Why?
Myelin Sheath120096510.060 Why?
Models, Immunological220065130.060 Why?
Metabolic Diseases120116850.060 Why?
Mice, Inbred NOD2202118370.060 Why?
Environmental Pollutants1201412600.060 Why?
Receptors, Antigen, T-Cell, alpha-beta120088010.060 Why?
Female1320243910110.060 Why?
Osteogenesis1201112710.060 Why?
Insulin-Like Growth Factor I2201219200.060 Why?
Dendritic Cells1201627300.060 Why?
Nuclear Proteins2201057930.060 Why?
S Phase220054220.060 Why?
Hep G2 Cells220173890.060 Why?
Gene Rearrangement, T-Lymphocyte120041110.060 Why?
Transplantation, Heterologous1201223780.060 Why?
Carcinoma, Non-Small-Cell Lung1202352480.060 Why?
Encephalomyelitis, Autoimmune, Experimental120098250.060 Why?
Fasting1201016030.060 Why?
DNA, Mitochondrial220238570.060 Why?
Disease Progression12021135050.060 Why?
Genotype22016129590.060 Why?
Glycoproteins1201122080.060 Why?
Atherosclerosis1202035240.060 Why?
HeLa Cells3201931050.060 Why?
Immunoglobulin Light Chains120042780.060 Why?
Radiation Tolerance120064800.060 Why?
Genes, Regulator120043740.060 Why?
Autophagy2200913360.050 Why?
Induced Pluripotent Stem Cells1201518430.050 Why?
NF-kappa B3201224860.050 Why?
Sequence Homology, Amino Acid1200727550.050 Why?
RNA Editing120041510.050 Why?
Gene Expression Profiling3201493880.050 Why?
Biological Transport2202120870.050 Why?
Glutarates120242440.050 Why?
Nucleoproteins120231130.050 Why?
RNA, Small Interfering4201734430.050 Why?
Apoptosis4201794970.050 Why?
Nucleotidyltransferases120242440.050 Why?
Protein Stability220175660.050 Why?
Somatomedins120221780.050 Why?
Drosophila melanogaster1201117110.050 Why?
Leukopoiesis12001550.050 Why?
Stress, Physiological1200913950.050 Why?
Phenylacetates120211130.050 Why?
Mitochondrial Proteins120079790.050 Why?
CLOCK Proteins22014860.050 Why?
Tumor Escape120243710.050 Why?
ARNTL Transcription Factors22014940.050 Why?
Life Expectancy1200812490.050 Why?
Endothelial Cells2201135370.050 Why?
Globins120014030.050 Why?
Hippocampus1201337370.050 Why?
Binding Sites3202160500.050 Why?
DNA Transposable Elements120247520.040 Why?
Dosage Compensation, Genetic120012070.040 Why?
Immunohistochemistry12014110640.040 Why?
Brain Neoplasms1202289840.040 Why?
Prader-Willi Syndrome12000760.040 Why?
Islets of Langerhans1200613410.040 Why?
RNA, Messenger22014127620.040 Why?
Diabetic Cardiomyopathies12021960.040 Why?
Base Sequence42016124470.040 Why?
Muscular Atrophy120223310.040 Why?
Environmental Exposure1201444040.040 Why?
Calcium1201257260.040 Why?
3' Untranslated Regions120215140.040 Why?
Hematopoiesis2202020630.040 Why?
Muscle Fibers, Skeletal120225430.040 Why?
Insulin-Secreting Cells120069070.040 Why?
Enzyme Activation2201736040.040 Why?
Proto-Oncogene Proteins c-fos120215860.040 Why?
In Situ Hybridization, Fluorescence2200125000.040 Why?
Lymphocyte Activation1200954980.040 Why?
Angelman Syndrome120001400.040 Why?
Receptors, Antigen, B-Cell120015450.040 Why?
Muscle, Skeletal2201149230.040 Why?
Cytokines2201273450.040 Why?
Congenital Abnormalities120037040.040 Why?
Homeostasis3201833050.040 Why?
Bone Density1201135280.040 Why?
Lung Neoplasms12023132490.040 Why?
Gene Rearrangement1200311220.040 Why?
Male1120213594130.040 Why?
Brain52023269120.040 Why?
Cerebral Cortex1201357550.040 Why?
Zebrafish3201729960.040 Why?
Phosphorylation3201783140.030 Why?
Antibody Diversity22007720.030 Why?
Lipoproteins, LDL120206410.030 Why?
Embryonic and Fetal Development119974200.030 Why?
Niacinamide220104140.030 Why?
Tumor Suppressor Protein p532200529270.030 Why?
Lymphoid Enhancer-Binding Factor 112016840.030 Why?
Electroretinography120185180.030 Why?
Receptors, CCR7120161080.030 Why?
MicroRNAs1201137840.030 Why?
Hepatocyte Nuclear Factor 1-alpha120161690.030 Why?
Membrane Transport Proteins1202110360.030 Why?
NIH 3T3 Cells220086700.030 Why?
Gene Knockdown Techniques1202016170.030 Why?
Glycogen Synthase Kinase 3120174090.030 Why?
Homozygote1202017860.030 Why?
Chromosome Mapping1200346250.030 Why?
Mice, Mutant Strains2200817600.030 Why?
Genetic Predisposition to Disease12016177660.030 Why?
Genome, Mitochondrial12014660.030 Why?
Apolipoproteins E1202014370.030 Why?
Breast Neoplasms12021210650.030 Why?
Blastocyst120174260.030 Why?
Tumor Cells, Cultured1202161310.030 Why?
Brain-Derived Neurotrophic Factor120175980.030 Why?
Cell Cycle3201029370.030 Why?
Heart Failure22021118350.030 Why?
Indoles1202118300.030 Why?
Interleukin-12120165840.030 Why?
Neurons2201094160.030 Why?
Glucocorticoids1202221430.030 Why?
CpG Islands1199712210.030 Why?
Animals, Genetically Modified1201715530.030 Why?
Chemokine CXCL2120121080.030 Why?
Genes, myc120133950.030 Why?
Toll-Like Receptors120165900.030 Why?
Organ Specificity1201719550.030 Why?
Sterol Regulatory Element Binding Proteins12011250.030 Why?
Methylation2201010800.030 Why?
Aorta1202020420.020 Why?
Neuroglia120179440.020 Why?
Bone Marrow Transplantation1202026960.020 Why?
Hydrolysis120136650.020 Why?
Saccharomyces cerevisiae1202327020.020 Why?
Cholesterol2201129250.020 Why?
Mice, Obese120124200.020 Why?
Hydrophobic and Hydrophilic Interactions120134000.020 Why?
Histocompatibility Antigens Class II1201614460.020 Why?
Myocardial Infarction12012118910.020 Why?
Diabetes Mellitus, Experimental1201711090.020 Why?
Naphthols12010460.020 Why?
Histone Deacetylase Inhibitors120167720.020 Why?
Blood Glucose2201763750.020 Why?
Retroviridae120128500.020 Why?
Cyclin E120101570.020 Why?
Histone Demethylases120123230.020 Why?
Insulin Receptor Substrate Proteins120115570.020 Why?
Lymphopoiesis120101330.020 Why?
Interleukin-8120126980.020 Why?
Introns120119780.020 Why?
Polymerase Chain Reaction1199860670.020 Why?
Myocardial Reperfusion Injury120124790.020 Why?
Specific Pathogen-Free Organisms120082200.020 Why?
Forkhead Transcription Factors2200716130.020 Why?
ATP-Binding Cassette Transporters120115630.020 Why?
Conserved Sequence1201111680.020 Why?
Plaque, Atherosclerotic1202015200.020 Why?
Crystallography, X-Ray1201319790.020 Why?
AMP-Activated Protein Kinases120116000.020 Why?
Receptor, Notch1120114950.020 Why?
Jurkat Cells120097360.020 Why?
Enzyme Stability120082200.020 Why?
Period Circadian Proteins12008960.020 Why?
Obesity12010129150.020 Why?
Poly(ADP-ribose) Polymerases120094280.020 Why?
Ubiquitin-Activating Enzymes12008880.020 Why?
Yeasts120082790.020 Why?
Starvation120081400.020 Why?
Food Deprivation120071140.020 Why?
Learning1201717330.020 Why?
Adipose Tissue, White120103650.020 Why?
Early Detection of Cancer1202232150.020 Why?
Neovascularization, Pathologic1201726410.020 Why?
Sulfonamides1201719730.020 Why?
Adenosine Diphosphate Ribose12006660.020 Why?
Vascular Endothelial Growth Factor A1201734830.020 Why?
Membrane Potentials1200910950.020 Why?
tau Proteins1201720950.020 Why?
Thymus Neoplasms120082740.020 Why?
Gene Rearrangement, B-Lymphocyte, Heavy Chain12006910.020 Why?
Solubility1200710880.020 Why?
Interleukin-61201632070.020 Why?
Oxidation-Reduction1201122220.020 Why?
Tumor Suppressor Protein p14ARF12005840.020 Why?
Regulatory Sequences, Nucleic Acid220017890.020 Why?
Histone Acetyltransferases120073370.020 Why?
Macrophages1202057450.020 Why?
Survival Rate22010128060.020 Why?
Benzamides1201013690.010 Why?
Antigens, Nuclear120051840.010 Why?
Rad51 Recombinase120051880.010 Why?
Epithelial Cells1201636650.010 Why?
Intercellular Signaling Peptides and Proteins1201116550.010 Why?
Gene Targeting120078390.010 Why?
DNA Breaks, Double-Stranded120086070.010 Why?
Morphogenesis120077400.010 Why?
Adenosine Triphosphate1200919950.010 Why?
Models, Genetic2200634420.010 Why?
Germ-Line Mutation1201118430.010 Why?
Thermogenesis120074680.010 Why?
Microtubule-Associated Proteins1200810780.010 Why?
Embryo, Mammalian1200816670.010 Why?
Dietary Fats1201019920.010 Why?
Basic Helix-Loop-Helix Transcription Factors1200811370.010 Why?
Leptin1201015900.010 Why?
Cyclin-Dependent Kinase Inhibitor p16120056980.010 Why?
Infrared Rays120032460.010 Why?
Locus Control Region12001210.010 Why?
Feedback120067910.010 Why?
Disease Models, Animal12021181340.010 Why?
Osteoporosis1201116000.010 Why?
Proteasome Endopeptidase Complex1200813140.010 Why?
Blood Vessels1200711120.010 Why?
Hydrogen Peroxide120057320.010 Why?
Adipose Tissue, Brown120077550.010 Why?
Enzyme-Linked Immunosorbent Assay1200938040.010 Why?
Proteomics1201538100.010 Why?
Reverse Transcriptase Polymerase Chain Reaction1200945730.010 Why?
Interferon-gamma1200931600.010 Why?
Caenorhabditis elegans1201014440.010 Why?
Mice, Inbred CBA120014360.010 Why?
Erythroid Precursor Cells120012110.010 Why?
Adaptor Proteins, Signal Transducing1201128950.010 Why?
Genetic Markers1200726080.010 Why?
Mesenchymal Stem Cells1201116340.010 Why?
Chromosomes, Human, Pair 11120014100.010 Why?
Cell Movement1201252060.010 Why?
Neovascularization, Physiologic1200713350.010 Why?
Amino Acids1200617150.010 Why?
Lymphoma1200818990.010 Why?
Repressor Proteins1201029780.010 Why?
Lipids1201033360.010 Why?
Doxorubicin1200522070.010 Why?
Antineoplastic Agents12021136290.010 Why?
Transgenes1200110060.010 Why?
Clone Cells1200116630.010 Why?
Fathers120003760.010 Why?
Enzyme Inhibitors1200837260.010 Why?
Transcription Factor RelB11996280.010 Why?
Nuclear Matrix11996300.010 Why?
Immunoglobulin mu-Chains11996620.010 Why?
Cerebellum1200414950.010 Why?
DNA Primers1200028190.010 Why?
Alzheimer Disease1201785510.010 Why?
Feeding Behavior1200731850.010 Why?
Recombinant Proteins1200465430.010 Why?
Intracellular Signaling Peptides and Proteins1200428740.010 Why?
Pedigree1200045770.010 Why?
Diabetes Mellitus, Type 212017122810.010 Why?
Inflammation12012107570.010 Why?
Rats12008236950.010 Why?
Mothers1200021860.010 Why?
Proteins1200460300.010 Why?
Adult120212198470.000 Why?
Time Factors12001401330.000 Why?
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© 2024 President and Fellows of Harvard College
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.