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Raul Mostoslavsky, M.D., Ph.D.

Concepts (499)

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Concepts are derived automatically from a person's publications.
Concepts are listed by decreasing relevance which is based on many factors, including how many publications the person wrote about that topic, how long ago those publications were written, and how many publications other people have written on that same topic.
Name Number of Publications Most Recent Publication Publications by All Authors Concept Score Why?
Sirtuins60202332213.070 Why?
DNA Repair14202220502.080 Why?
Chromatin16202229671.970 Why?
Glycolysis820228381.430 Why?
Histones14202125931.410 Why?
Genomic Instability1020217151.370 Why?
DNA Damage13202224591.210 Why?
Epigenesis, Genetic12202438261.200 Why?
Sirtuin 11720142460.980 Why?
Acetylation18201910530.950 Why?
Chromatin Assembly and Disassembly620216320.940 Why?
Cell Nucleus5202028870.930 Why?
Energy Metabolism6201629060.840 Why?
Glutamine320235780.820 Why?
Acetyl Coenzyme A32017740.810 Why?
Glutathione Transferase120245640.790 Why?
Longevity8201410770.760 Why?
Aging13202387640.760 Why?
DNA Repair Enzymes120213460.680 Why?
Neoplasms142024223890.670 Why?
Cell Transformation, Neoplastic4202228460.660 Why?
Animals9320241693220.650 Why?
Open Reading Frames120218120.610 Why?
DNA Replication4202014290.590 Why?
Disease220136730.560 Why?
Cytosine220152130.560 Why?
DNA, Ribosomal120183010.560 Why?
Hepatocyte Nuclear Factor 3-alpha120171650.550 Why?
RNA Polymerase II220215470.520 Why?
Pancreatic Neoplasms4202454430.500 Why?
Neoplastic Stem Cells2202113560.500 Why?
Mitosis2202111900.490 Why?
Embryonic Stem Cells5201812490.490 Why?
Mice642024820040.490 Why?
Sirtuin 232014930.480 Why?
Histone Deacetylases420137170.470 Why?
Germ-Free Life120141870.460 Why?
Immunoprecipitation320138740.460 Why?
Butyrates120141680.450 Why?
Immunoglobulin kappa-Chains520071710.450 Why?
Chromatin Immunoprecipitation220138550.430 Why?
Proto-Oncogene Proteins3201545260.430 Why?
Cells120141660.420 Why?
Transcription, Genetic10202175990.410 Why?
Mice, Knockout212021144810.410 Why?
Enhancer Elements, Genetic4201713680.410 Why?
Nucleosomes220134890.400 Why?
Immune System420038010.400 Why?
Glucose7201743540.390 Why?
Acetyltransferases120132310.390 Why?
Gene Expression Regulation122018119140.390 Why?
Sirtuin 322011660.380 Why?
Mammals5202311350.370 Why?
Tumor Microenvironment1202439400.360 Why?
Dietary Fiber120147680.360 Why?
Point Mutation1201515950.350 Why?
Gene Expression Regulation, Neoplastic5202486280.340 Why?
Promoter Regions, Genetic4202158000.330 Why?
Hypoxia-Inducible Factor 1, alpha Subunit220106230.320 Why?
DNA Methylation11202444190.320 Why?
Adenosine Triphosphatases120138420.320 Why?
DNA-Binding Proteins4201596180.310 Why?
Alleles8200868920.300 Why?
Chromosomal Proteins, Non-Histone120137310.300 Why?
NAD720236180.300 Why?
Humans8020247682980.290 Why?
Cell Differentiation62018116590.290 Why?
Proto-Oncogene Proteins c-myc420209970.280 Why?
Retina2201826610.280 Why?
RNA-Binding Proteins1201618830.280 Why?
Mitochondria6202336750.280 Why?
Cell Proliferation102023104640.280 Why?
Acetaminophen120115560.280 Why?
Epigenomics120139590.280 Why?
Cell Lineage2201625740.280 Why?
Fungal Proteins120119060.270 Why?
Neoplasm Metastasis3202449210.270 Why?
Head and Neck Neoplasms1202129230.270 Why?
Ovarian Neoplasms1202249080.250 Why?
Gene Rearrangement, B-Lymphocyte, Light Chain32001180.250 Why?
5-Methylcytosine220151470.240 Why?
Genes, T-Cell Receptor12004290.240 Why?
Drosophila Proteins2201117130.240 Why?
SOXB1 Transcription Factors220162850.230 Why?
Caenorhabditis elegans Proteins120118780.220 Why?
Mice, Inbred C57BL122024223550.220 Why?
Adenocarcinoma2202464040.220 Why?
Gene Deletion3202026730.220 Why?
Mice, SCID4202126320.210 Why?
Dioxygenases220153510.210 Why?
Protein Processing, Post-Translational5201819670.200 Why?
Phenotype82017167160.200 Why?
Antibody Specificity1200410650.200 Why?
Glutamates120233850.200 Why?
Nicotinamide Phosphoribosyltransferase32012850.200 Why?
Proline120234550.190 Why?
Glucose Transporter Type 1220141860.190 Why?
B-Lymphocytes7200747850.190 Why?
Nuclear Receptor Subfamily 4, Group A, Member 112021660.190 Why?
Signal Transduction152023236290.190 Why?
Cell Line, Tumor92024171320.190 Why?
Genetic Diseases, Inborn120066050.180 Why?
Metabolism220121930.180 Why?
Fatty Acids3202118170.180 Why?
Cell Cycle Proteins5201934570.180 Why?
Heart Diseases1201428190.180 Why?
Immune Evasion120243760.180 Why?
Genes, Immunoglobulin420062860.180 Why?
Pentose Phosphate Pathway120211260.180 Why?
Pluripotent Stem Cells220188080.180 Why?
Fibronectins120247240.180 Why?
DNA4202472110.180 Why?
NF-E2-Related Factor 2120233780.170 Why?
Scavenger Receptors, Class A12020520.170 Why?
Gene Expression Regulation, Developmental6201536120.170 Why?
Transcription Factors92022121660.170 Why?
Insulin4201766080.160 Why?
Epithelial-Mesenchymal Transition120247550.160 Why?
Lymphocytes2200626100.160 Why?
Down-Regulation5202029370.160 Why?
Kinetics3202163340.160 Why?
Tumor Suppressor Proteins3201628110.160 Why?
Immediate-Early Proteins120214440.160 Why?
Adipocytes, Brown120191600.150 Why?
Glutathione120215850.150 Why?
Lipolysis120192110.150 Why?
PPAR gamma120214870.150 Why?
Caloric Restriction320103000.150 Why?
RNA, Neoplasm120217490.150 Why?
Transcriptional Elongation Factors120191670.150 Why?
Fibroblasts6201741750.150 Why?
Isocitrate Dehydrogenase120249540.150 Why?
Xenograft Model Antitumor Assays3202136160.150 Why?
HMGB Proteins12017450.150 Why?
Mice, 129 Strain220163690.150 Why?
Embryoid Bodies12018650.140 Why?
Lysine320139880.140 Why?
Cell Line72019155930.140 Why?
Dual-Specificity Phosphatases12017710.140 Why?
Gene Knockout Techniques420128080.140 Why?
Gene Expression Regulation, Enzymologic2201211690.130 Why?
Receptors, Notch220117490.130 Why?
Antibodies1200424250.130 Why?
Mutation52024302300.130 Why?
Cell Survival2202457920.130 Why?
Fetal Death120184380.130 Why?
Metabolic Networks and Pathways120207980.130 Why?
High-Throughput Screening Assays120219370.130 Why?
Trans-Activators3201228550.130 Why?
Models, Biological7202094940.130 Why?
Adenomatous Polyposis Coli Protein120161820.130 Why?
Quinazolinones120172190.120 Why?
Diabetes Mellitus1201458900.120 Why?
Reactive Oxygen Species4202321460.120 Why?
Genes, ras220166650.120 Why?
Oxidative Stress6202331390.120 Why?
Tumor Necrosis Factor-alpha5201643570.120 Why?
Colorectal Neoplasms1201469690.120 Why?
Gene Expression3201875950.120 Why?
High Mobility Group Proteins120151790.120 Why?
Neoplastic Cells, Circulating120219570.120 Why?
Cells, Cultured82016190190.110 Why?
Eye Proteins120186280.110 Why?
Octamer Transcription Factor-3120152210.110 Why?
p300-CBP Transcription Factors220121500.110 Why?
Lipid Metabolism2201419000.110 Why?
Mixed Function Oxygenases120152650.110 Why?
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma120173840.110 Why?
Proto-Oncogene Proteins c-akt1202224610.110 Why?
Phosphatidylinositol 3-Kinases3202228840.110 Why?
Receptors, Glutamate120142290.110 Why?
X Chromosome120178190.110 Why?
T-Lymphocytes42017102660.110 Why?
Catalytic Domain120156980.110 Why?
Acrylamides220122600.110 Why?
Circadian Rhythm3201625880.110 Why?
Antioxidants1202116730.100 Why?
Intestines1202219110.100 Why?
Myocytes, Cardiac2202116830.100 Why?
Glucose Intolerance120175790.100 Why?
Oncogene Protein v-akt120121300.100 Why?
Genomic Imprinting320173240.100 Why?
Genome1202017470.100 Why?
Immunoglobulin Heavy Chains220066480.100 Why?
Teratoma120154050.100 Why?
Immunity, Innate1202430790.100 Why?
HEK293 Cells5202142860.100 Why?
S-Adenosylmethionine120132200.100 Why?
Gluconeogenesis120121860.100 Why?
Transfection3201557580.100 Why?
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization120135040.100 Why?
Bone Marrow2202029290.090 Why?
Methyltransferases220133730.090 Why?
Hepatocytes2202212450.090 Why?
Liver5201475700.090 Why?
JNK Mitogen-Activated Protein Kinases120124400.090 Why?
Oxidoreductases, N-Demethylating120111090.090 Why?
Electron Transport120112110.090 Why?
Growth and Development12010460.090 Why?
Sterol Regulatory Element Binding Protein 212010580.090 Why?
Gene Rearrangement, beta-Chain T-Cell Antigen Receptor22008940.090 Why?
Glutamate Dehydrogenase22007500.090 Why?
Pro-Opiomelanocortin120101390.090 Why?
Citric Acid Cycle120112340.090 Why?
Sterol Regulatory Element Binding Protein 1120101360.090 Why?
Recombination, Genetic2200615260.080 Why?
Cardiomegaly120125910.080 Why?
Acetates120113170.080 Why?
Mice, Transgenic8201995630.080 Why?
Isoenzymes1201416840.080 Why?
Neutrophil Infiltration120123950.080 Why?
Single-Cell Analysis1202125330.080 Why?
Cell Respiration120102010.080 Why?
Adaptation, Physiological1201613150.080 Why?
Neoplasm Transplantation1201220170.080 Why?
Molecular Sequence Data42015176260.080 Why?
Genes, T-Cell Receptor beta12008700.080 Why?
Neurogenesis120158640.080 Why?
Neurodegenerative Diseases1201710940.080 Why?
RNA Interference2201528360.080 Why?
Mice, Inbred BALB C4201662280.080 Why?
RecQ Helicases12008530.080 Why?
Base Pair Mismatch12008930.080 Why?
Diabetic Retinopathy1201712990.080 Why?
Silent Information Regulator Proteins, Saccharomyces cerevisiae12007620.070 Why?
Gene Silencing3201715010.070 Why?
Carbon-Carbon Double Bond Isomerases1200750.070 Why?
Enoyl-CoA Hydratase12007110.070 Why?
Acetyl-CoA C-Acyltransferase12007230.070 Why?
3-Hydroxyacyl CoA Dehydrogenases12007590.070 Why?
Fatty Liver120138070.070 Why?
Gene Rearrangement, B-Lymphocyte120071110.070 Why?
Cluster Analysis1201427270.070 Why?
Exodeoxyribonucleases120081910.070 Why?
Somatic Hypermutation, Immunoglobulin120071030.070 Why?
Mitochondria, Liver120071910.070 Why?
Racemases and Epimerases120071140.070 Why?
Immunoglobulin Variable Region320074200.070 Why?
Mice, Nude1201236300.070 Why?
Piperidines2201216600.070 Why?
Amino Acid Sequence22015134250.070 Why?
Mitochondria, Muscle120071720.060 Why?
Stomach Neoplasms1201614810.060 Why?
Liver Neoplasms1202243600.060 Why?
Acylation22018980.060 Why?
Homeodomain Proteins1201524290.060 Why?
Myelin Sheath120096530.060 Why?
Adenoma1201621630.060 Why?
Models, Immunological220065180.060 Why?
Metabolic Diseases120116840.060 Why?
Mice, Inbred NOD2202118390.060 Why?
Environmental Pollutants1201412900.060 Why?
Receptors, Antigen, T-Cell, alpha-beta120088080.060 Why?
Nuclear Proteins2201058020.060 Why?
Osteogenesis1201112910.060 Why?
Insulin-Like Growth Factor I2201219430.060 Why?
Female1320243970500.060 Why?
S Phase220054230.060 Why?
Hep G2 Cells220173750.060 Why?
Dendritic Cells1201627490.060 Why?
Gene Rearrangement, T-Lymphocyte120041110.060 Why?
Transplantation, Heterologous1201223940.060 Why?
Carcinoma, Non-Small-Cell Lung1202354220.060 Why?
Encephalomyelitis, Autoimmune, Experimental120098220.060 Why?
Fasting1201016100.060 Why?
Genotype22016130380.060 Why?
Atherosclerosis1202034310.060 Why?
DNA, Mitochondrial220238710.060 Why?
Glycoproteins1201122040.060 Why?
Disease Progression12021136460.060 Why?
HeLa Cells3201930920.050 Why?
Radiation Tolerance120064780.050 Why?
Genes, Regulator120043730.050 Why?
Autophagy2200913500.050 Why?
Immunoglobulin Light Chains120042890.050 Why?
NF-kappa B3201224870.050 Why?
Sequence Homology, Amino Acid1200727500.050 Why?
Induced Pluripotent Stem Cells1201518890.050 Why?
RNA Editing120041490.050 Why?
Nucleoproteins120231100.050 Why?
Gene Expression Profiling3201495080.050 Why?
Biological Transport2202120860.050 Why?
Glutarates120242430.050 Why?
RNA, Small Interfering4201734360.050 Why?
Apoptosis4201795060.050 Why?
Nucleotidyltransferases120242430.050 Why?
Somatomedins120221790.050 Why?
Protein Stability220175790.050 Why?
Leukopoiesis12001540.050 Why?
Drosophila melanogaster1201117230.050 Why?
Stress, Physiological1200914100.050 Why?
Phenylacetates120211120.050 Why?
Mitochondrial Proteins120079780.050 Why?
CLOCK Proteins22014870.050 Why?
Tumor Escape120243720.050 Why?
ARNTL Transcription Factors22014970.050 Why?
Life Expectancy1200812490.050 Why?
Globins120014050.050 Why?
Endothelial Cells2201135870.040 Why?
Binding Sites3202160180.040 Why?
Hippocampus1201337840.040 Why?
Dosage Compensation, Genetic120012090.040 Why?
DNA Transposable Elements120247620.040 Why?
Immunohistochemistry12014111170.040 Why?
Brain Neoplasms1202291970.040 Why?
RNA, Messenger22014128010.040 Why?
Islets of Langerhans1200613490.040 Why?
Prader-Willi Syndrome12000790.040 Why?
Diabetic Cardiomyopathies12021910.040 Why?
Base Sequence42016124210.040 Why?
Muscular Atrophy120223350.040 Why?
3' Untranslated Regions120215150.040 Why?
Calcium1201257940.040 Why?
Environmental Exposure1201445280.040 Why?
Hematopoiesis2202020580.040 Why?
Insulin-Secreting Cells120068990.040 Why?
Enzyme Activation2201735850.040 Why?
Muscle Fibers, Skeletal120225520.040 Why?
Proto-Oncogene Proteins c-fos120215830.040 Why?
Lymphocyte Activation1200954960.040 Why?
Angelman Syndrome120001390.040 Why?
In Situ Hybridization, Fluorescence2200125240.040 Why?
Receptors, Antigen, B-Cell120015470.040 Why?
Congenital Abnormalities120037080.040 Why?
Muscle, Skeletal2201149810.040 Why?
Cytokines2201274430.040 Why?
Bone Density1201135590.040 Why?
Homeostasis3201833490.040 Why?
Lung Neoplasms12023135760.040 Why?
Gene Rearrangement1200311390.040 Why?
Male1120213648700.040 Why?
Brain52023274520.040 Why?
Cerebral Cortex1201358300.030 Why?
Phosphorylation3201783260.030 Why?
Zebrafish3201730370.030 Why?
Antibody Diversity22007720.030 Why?
Lipoproteins, LDL120206430.030 Why?
Embryonic and Fetal Development119974200.030 Why?
Niacinamide220104170.030 Why?
Tumor Suppressor Protein p532200529500.030 Why?
Lymphoid Enhancer-Binding Factor 112016840.030 Why?
Electroretinography120185240.030 Why?
Receptors, CCR7120161050.030 Why?
MicroRNAs1201137940.030 Why?
Membrane Transport Proteins1202110340.030 Why?
Hepatocyte Nuclear Factor 1-alpha120161730.030 Why?
NIH 3T3 Cells220086690.030 Why?
Gene Knockdown Techniques1202016080.030 Why?
Glycogen Synthase Kinase 3120174140.030 Why?
Homozygote1202017790.030 Why?
Chromosome Mapping1200346220.030 Why?
Mice, Mutant Strains2200817550.030 Why?
Genetic Predisposition to Disease12016180470.030 Why?
Genome, Mitochondrial12014680.030 Why?
Breast Neoplasms12021211630.030 Why?
Apolipoproteins E1202014590.030 Why?
Blastocyst120174320.030 Why?
Tumor Cells, Cultured1202161320.030 Why?
Cell Cycle3201029340.030 Why?
Brain-Derived Neurotrophic Factor120176070.030 Why?
Heart Failure22021118600.030 Why?
Indoles1202118250.030 Why?
Interleukin-12120165770.030 Why?
Neurons2201095120.030 Why?
Glucocorticoids1202221680.030 Why?
CpG Islands1199712080.030 Why?
Animals, Genetically Modified1201715630.030 Why?
Genes, myc120133910.030 Why?
Chemokine CXCL2120121050.030 Why?
Toll-Like Receptors120165820.020 Why?
Methylation2201010760.020 Why?
Sterol Regulatory Element Binding Proteins12011250.020 Why?
Organ Specificity1201719660.020 Why?
Aorta1202020460.020 Why?
Hydrolysis120136480.020 Why?
Saccharomyces cerevisiae1202326780.020 Why?
Cholesterol2201129120.020 Why?
Bone Marrow Transplantation1202027090.020 Why?
Mice, Obese120124180.020 Why?
Neuroglia120179600.020 Why?
Hydrophobic and Hydrophilic Interactions120133950.020 Why?
Histocompatibility Antigens Class II1201614380.020 Why?
Myocardial Infarction12012115150.020 Why?
Histone Deacetylase Inhibitors120167750.020 Why?
Diabetes Mellitus, Experimental1201711220.020 Why?
Naphthols12010460.020 Why?
Blood Glucose2201764300.020 Why?
Retroviridae120128490.020 Why?
Cyclin E120101560.020 Why?
Histone Demethylases120123220.020 Why?
Insulin Receptor Substrate Proteins120115580.020 Why?
Lymphopoiesis120101330.020 Why?
Interleukin-8120127040.020 Why?
Introns120119680.020 Why?
Polymerase Chain Reaction1199860840.020 Why?
Myocardial Reperfusion Injury120124840.020 Why?
Specific Pathogen-Free Organisms120082200.020 Why?
Forkhead Transcription Factors2200716220.020 Why?
ATP-Binding Cassette Transporters120115670.020 Why?
Conserved Sequence1201111630.020 Why?
Crystallography, X-Ray1201319560.020 Why?
AMP-Activated Protein Kinases120115980.020 Why?
Plaque, Atherosclerotic1202015480.020 Why?
Jurkat Cells120097380.020 Why?
Enzyme Stability120082190.020 Why?
Period Circadian Proteins12008960.020 Why?
Receptor, Notch1120115200.020 Why?
Obesity12010130820.020 Why?
Ubiquitin-Activating Enzymes12008850.020 Why?
Poly(ADP-ribose) Polymerases120094270.020 Why?
Yeasts120082790.020 Why?
Starvation120081410.020 Why?
Food Deprivation120071140.020 Why?
Learning1201717600.020 Why?
Neovascularization, Pathologic1201726350.020 Why?
Early Detection of Cancer1202232360.020 Why?
Adipose Tissue, White120103710.020 Why?
Sulfonamides1201719800.020 Why?
Adenosine Diphosphate Ribose12006700.020 Why?
Vascular Endothelial Growth Factor A1201735200.020 Why?
Membrane Potentials1200910900.020 Why?
tau Proteins1201721420.020 Why?
Thymus Neoplasms120082770.020 Why?
Gene Rearrangement, B-Lymphocyte, Heavy Chain12006910.020 Why?
Solubility1200710850.020 Why?
Interleukin-61201632300.020 Why?
Tumor Suppressor Protein p14ARF12005840.020 Why?
Oxidation-Reduction1201122250.020 Why?
Regulatory Sequences, Nucleic Acid220017920.020 Why?
Histone Acetyltransferases120073350.020 Why?
Survival Rate22010128700.010 Why?
Macrophages1202057960.010 Why?
Benzamides1201013800.010 Why?
Antigens, Nuclear120051830.010 Why?
Rad51 Recombinase120051910.010 Why?
Epithelial Cells1201636920.010 Why?
Intercellular Signaling Peptides and Proteins1201116580.010 Why?
Gene Targeting120078410.010 Why?
DNA Breaks, Double-Stranded120086150.010 Why?
Morphogenesis120077470.010 Why?
Models, Genetic2200634420.010 Why?
Adenosine Triphosphate1200920030.010 Why?
Thermogenesis120074940.010 Why?
Germ-Line Mutation1201118850.010 Why?
Microtubule-Associated Proteins1200810780.010 Why?
Embryo, Mammalian1200816740.010 Why?
Dietary Fats1201020030.010 Why?
Basic Helix-Loop-Helix Transcription Factors1200811410.010 Why?
Leptin1201015970.010 Why?
Infrared Rays120032490.010 Why?
Locus Control Region12001210.010 Why?
Cyclin-Dependent Kinase Inhibitor p16120057100.010 Why?
Feedback120067950.010 Why?
Blood Vessels1200711100.010 Why?
Osteoporosis1201116060.010 Why?
Proteasome Endopeptidase Complex1200813200.010 Why?
Disease Models, Animal12021183580.010 Why?
Hydrogen Peroxide120057420.010 Why?
Reverse Transcriptase Polymerase Chain Reaction1200945840.010 Why?
Enzyme-Linked Immunosorbent Assay1200938110.010 Why?
Adipose Tissue, Brown120077760.010 Why?
Proteomics1201539060.010 Why?
Interferon-gamma1200931640.010 Why?
Mice, Inbred CBA120014380.010 Why?
Caenorhabditis elegans1201014670.010 Why?
Adaptor Proteins, Signal Transducing1201129110.010 Why?
Erythroid Precursor Cells120012120.010 Why?
Genetic Markers1200726040.010 Why?
Mesenchymal Stem Cells1201116660.010 Why?
Chromosomes, Human, Pair 11120014110.010 Why?
Cell Movement1201252140.010 Why?
Neovascularization, Physiologic1200713710.010 Why?
Amino Acids1200617160.010 Why?
Lymphoma1200819070.010 Why?
Repressor Proteins1201029860.010 Why?
Lipids1201033440.010 Why?
Antineoplastic Agents12021136960.010 Why?
Doxorubicin1200522290.010 Why?
Transgenes1200110150.010 Why?
Clone Cells1200116710.010 Why?
Fathers120003780.010 Why?
Enzyme Inhibitors1200837220.010 Why?
Transcription Factor RelB11996290.010 Why?
Nuclear Matrix11996300.010 Why?
Immunoglobulin mu-Chains11996620.010 Why?
Cerebellum1200415140.010 Why?
DNA Primers1200028230.010 Why?
Alzheimer Disease1201787470.010 Why?
Feeding Behavior1200732030.010 Why?
Recombinant Proteins1200465120.010 Why?
Intracellular Signaling Peptides and Proteins1200428890.010 Why?
Pedigree1200045450.010 Why?
Diabetes Mellitus, Type 212017122390.010 Why?
Inflammation12012108630.010 Why?
Rats12008238330.010 Why?
Mothers1200022110.010 Why?
Proteins1200460060.000 Why?
Adult120212236220.000 Why?
Time Factors12001402670.000 Why?
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.