Histocompatibility Antigens Class II
"Histocompatibility Antigens Class II" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Large, transmembrane, non-covalently linked glycoproteins (alpha and beta). Both chains can be polymorphic although there is more structural variation in the beta chains. The class II antigens in humans are called HLA-D ANTIGENS and are coded by a gene on chromosome 6. In mice, two genes named IA and IE on chromosome 17 code for the H-2 antigens. The antigens are found on B-lymphocytes, macrophages, epidermal cells, and sperm and are thought to mediate the competence of and cellular cooperation in the immune response. The term IA antigens used to refer only to the proteins encoded by the IA genes in the mouse, but is now used as a generic term for any class II histocompatibility antigen.
MeSH Number(s)
D12.776.395.550.509
D12.776.543.550.423
D23.050.301.500.400
D23.050.705.552.410
Concept/Terms
Histocompatibility Antigens Class II- Histocompatibility Antigens Class II
- I-A-Antigen
- I A Antigen
- IA Antigen
- Antigen, IA
- Ia Antigens
- Antigens, Ia
- Ia-Like Antigens
- Antigens, Ia-Like
- Ia Like Antigens
- Class II Major Histocompatibility Antigens
- Immune-Response-Associated Antigens
- Antigens, Immune-Response-Associated
- Immune Response Associated Antigens
- Antigens, Immune Response
- Class II Antigen
- Antigen, Class II
- Class II Antigens
- Antigens, Class II
- Class II Histocompatibility Antigens
- I-A Antigen
- Antigen, I-A
- Immune Response Antigens
Below are MeSH descriptors whose meaning is more general than "Histocompatibility Antigens Class II".
Below are MeSH descriptors whose meaning is more specific than "Histocompatibility Antigens Class II".
This graph shows the total number of publications written about "Histocompatibility Antigens Class II" by people in Harvard Catalyst Profiles by year, and whether "Histocompatibility Antigens Class II" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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1994 | 17 | 24 | 41 |
1995 | 19 | 9 | 28 |
1996 | 14 | 15 | 29 |
1997 | 15 | 14 | 29 |
1998 | 10 | 13 | 23 |
1999 | 23 | 18 | 41 |
2000 | 14 | 14 | 28 |
2001 | 5 | 16 | 21 |
2002 | 14 | 8 | 22 |
2003 | 12 | 12 | 24 |
2004 | 8 | 12 | 20 |
2005 | 13 | 10 | 23 |
2006 | 7 | 9 | 16 |
2007 | 7 | 9 | 16 |
2008 | 6 | 14 | 20 |
2009 | 12 | 5 | 17 |
2010 | 8 | 9 | 17 |
2011 | 9 | 6 | 15 |
2012 | 6 | 11 | 17 |
2013 | 4 | 15 | 19 |
2014 | 5 | 3 | 8 |
2015 | 4 | 8 | 12 |
2016 | 1 | 3 | 4 |
2017 | 7 | 4 | 11 |
2018 | 6 | 6 | 12 |
2019 | 3 | 8 | 11 |
2020 | 3 | 6 | 9 |
2021 | 5 | 9 | 14 |
2022 | 0 | 3 | 3 |
2023 | 0 | 12 | 12 |
2024 | 1 | 2 | 3 |
Below are the most recent publications written about "Histocompatibility Antigens Class II" by people in Profiles.
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Human Leukocyte Antigen Signatures as Pathophysiological Discriminants of Microscopic Colitis Subtypes. J Crohns Colitis. 2024 Mar 01; 18(3):349-359.
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An immunogenetic basis for lung cancer risk. Science. 2024 Feb 23; 383(6685):eadi3808.
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Proteogenomic characterization of primary colorectal cancer and metastatic progression identifies proteome-based subtypes and signatures. Cell Rep. 2024 Feb 27; 43(2):113810.
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MHC Tetramers Specifically Identify High- and Low-avidity Donor-specific B Cells in Transplantation Tolerance and Rejection. Transplantation. 2023 Dec 01; 107(12):2526-2532.
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MHC class II regulation of CD8+ T cell tolerance and implications in autoimmunity and cancer immunotherapy. Cell Rep. 2023 11 28; 42(11):113452.
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HLA allele-calling using multi-ancestry whole-exome sequencing from the UK Biobank identifies 129 novel associations in 11 autoimmune diseases. Commun Biol. 2023 11 03; 6(1):1113.
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Antigen presentation by B cells enables epitope spreading across an MHC barrier. Nat Commun. 2023 10 31; 14(1):6941.
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Heterozygote advantage at HLA class I and II loci and reduced risk of colorectal cancer. Front Immunol. 2023; 14:1268117.
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Lung injury induces a polarized immune response by self-antigen-specific CD4+ Foxp3+ regulatory T cells. Cell Rep. 2023 08 29; 42(8):112839.
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HLA class I signal peptide polymorphism determines the level of CD94/NKG2-HLA-E-mediated regulation of effector cell responses. Nat Immunol. 2023 07; 24(7):1087-1097.