"Apoptosis" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Concept/Terms
Apoptosis- Apoptosis
- Programmed Cell Death, Type I
Below are MeSH descriptors whose meaning is more general than "Apoptosis".
Below are MeSH descriptors whose meaning is more specific than "Apoptosis".
This graph shows the total number of publications written about "Apoptosis" by people in Harvard Catalyst Profiles by year, and whether "Apoptosis" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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1994 | 13 | 7 | 20 |
1995 | 22 | 21 | 43 |
1996 | 41 | 25 | 66 |
1997 | 70 | 33 | 103 |
1998 | 76 | 64 | 140 |
1999 | 97 | 73 | 170 |
2000 | 99 | 81 | 180 |
2001 | 82 | 94 | 176 |
2002 | 101 | 133 | 234 |
2003 | 97 | 154 | 251 |
2004 | 107 | 147 | 254 |
2005 | 113 | 181 | 294 |
2006 | 113 | 166 | 279 |
2007 | 90 | 152 | 242 |
2008 | 103 | 162 | 265 |
2009 | 93 | 166 | 259 |
2010 | 94 | 166 | 260 |
2011 | 83 | 216 | 299 |
2012 | 82 | 190 | 272 |
2013 | 90 | 214 | 304 |
2014 | 76 | 208 | 284 |
2015 | 65 | 215 | 280 |
2016 | 74 | 193 | 267 |
2017 | 57 | 226 | 283 |
2018 | 64 | 167 | 231 |
2019 | 53 | 187 | 240 |
2020 | 47 | 181 | 228 |
2021 | 34 | 133 | 167 |
2022 | 13 | 66 | 79 |
2023 | 11 | 44 | 55 |
2024 | 0 | 9 | 9 |
Below are the most recent publications written about "Apoptosis" by people in Profiles.
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Multiomic profiling of breast cancer cells uncovers stress MAPK-associated sensitivity to AKT degradation. Sci Signal. 2024 Feb 27; 17(825):eadf2670.
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The UBE2J2/UBE2K-MARCH5 ubiquitination machinery regulates apoptosis in response to venetoclax in acute myeloid leukemia. Leukemia. 2024 Mar; 38(3):652-656.
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Exercise Inhibits Doxorubicin-Induced Cardiotoxicity via Regulating B Cells. Circ Res. 2024 Mar; 134(5):550-568.
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First-in-Human Study with Preclinical Data of BCL-2/BCL-xL Inhibitor Pelcitoclax in Locally Advanced or Metastatic Solid Tumors. Clin Cancer Res. 2024 Feb 01; 30(3):506-521.
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MITOL deficiency triggers hematopoietic stem cell apoptosis via ER stress response. EMBO J. 2024 Feb; 43(3):339-361.
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Mutation of p53 increases the competitive ability of pluripotent stem cells. Development. 2024 Jan 15; 151(2).
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Gasdermin E dictates inflammatory responses by controlling the mode of neutrophil death. Nat Commun. 2024 Jan 09; 15(1):386.
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Germline mitotic quiescence and cell death are induced in Caenorhabditis elegans by exposure to pathogenic Pseudomonas aeruginosa. Genetics. 2024 Jan 03; 226(1).
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Hypomethylating agent decitabine sensitizes diffuse large B-cell lymphoma to venetoclax. Haematologica. 2024 Jan 01; 109(1):186-199.
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Developing and characterizing a two-layered safety switch for cell therapies. Cancer Biol Ther. 2023 12 31; 24(1):2232146.