"Mice, SCID" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Mice homozygous for the mutant autosomal recessive gene "scid" which is located on the centromeric end of chromosome 16. These mice lack mature, functional lymphocytes and are thus highly susceptible to lethal opportunistic infections if not chronically treated with antibiotics. The lack of B- and T-cell immunity resembles severe combined immunodeficiency (SCID) syndrome in human infants. SCID mice are useful as animal models since they are receptive to implantation of a human immune system producing SCID-human (SCID-hu) hematochimeric mice.
MeSH Number(s)
B01.050.150.900.649.865.635.505.500.550.780
Concept/Terms
Mice, SCID- Mice, SCID
- Severe Combined Immunodeficient Mice
- SCID Mice
- Immunodeficient Mice, Severe Combined
- Mouse, SCID
- SCID Mouse
Mouse, SCID-hu- Mouse, SCID-hu
- Mouse, SCID hu
- SCID-hu Mouse
- SCID-hu Mice
- Mice, SCID-hu
- SCID hu Mice
Below are MeSH descriptors whose meaning is more general than "Mice, SCID".
Below are MeSH descriptors whose meaning is more specific than "Mice, SCID".
This graph shows the total number of publications written about "Mice, SCID" by people in Harvard Catalyst Profiles by year, and whether "Mice, SCID" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 2 | 18 | 20 |
| 1995 | 0 | 25 | 25 |
| 1996 | 2 | 23 | 25 |
| 1997 | 2 | 25 | 27 |
| 1998 | 0 | 14 | 14 |
| 1999 | 1 | 35 | 36 |
| 2000 | 0 | 26 | 26 |
| 2001 | 0 | 27 | 27 |
| 2002 | 1 | 37 | 38 |
| 2003 | 0 | 39 | 39 |
| 2004 | 0 | 35 | 35 |
| 2005 | 0 | 39 | 39 |
| 2006 | 0 | 41 | 41 |
| 2007 | 0 | 47 | 47 |
| 2008 | 0 | 43 | 43 |
| 2009 | 0 | 55 | 55 |
| 2010 | 0 | 58 | 58 |
| 2011 | 1 | 80 | 81 |
| 2012 | 0 | 88 | 88 |
| 2013 | 0 | 75 | 75 |
| 2014 | 0 | 86 | 86 |
| 2015 | 0 | 71 | 71 |
| 2016 | 0 | 61 | 61 |
| 2017 | 0 | 69 | 69 |
| 2018 | 0 | 87 | 87 |
| 2019 | 0 | 74 | 74 |
| 2020 | 0 | 57 | 57 |
| 2021 | 0 | 72 | 72 |
| 2022 | 0 | 7 | 7 |
| 2023 | 0 | 3 | 3 |
| 2024 | 0 | 2 | 2 |
Below are the most recent publications written about "Mice, SCID" by people in Profiles.
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Genetically corrected RAG2-SCID human hematopoietic stem cells restore V(D)J-recombinase and rescue lymphoid deficiency. Blood Adv. 2024 Apr 09; 8(7):1820-1833.
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Fatty Acids Play a Critical Role in Mitochondrial Oxidative Phosphorylation in Effector T Cells in Graft-versus-Host Disease. Immunohorizons. 2024 Mar 01; 8(3):228-241.
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Transcriptomics confirm the establishment of a liver-immune dual-humanized mouse model after transplantation of a single type of human bone marrow mesenchymal stem cell. Liver Int. 2023 06; 43(6):1345-1356.
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Possible role of combined therapy targeting MET and pro-HGF activation for renal cell carcinoma: analysis by human HGF-producing SCID mice. Hum Cell. 2023 Mar; 36(2):775-785.
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CRISPR-Cas9-AAV versus lentivector transduction for genome modification of X-linked severe combined immunodeficiency hematopoietic stem cells. Front Immunol. 2022; 13:1067417.
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Bioluminescent Monitoring of Graft Survival in an Adoptive Transfer Model of Autoimmune Diabetes in Mice. J Vis Exp. 2022 Nov 18; (189).
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Targeting breast and pancreatic cancer metastasis using a dual-cadherin antibody. Proc Natl Acad Sci U S A. 2022 10 25; 119(43):e2209563119.
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Single-nucleus RNA-Seq reveals singular gene signatures of human ductal cells during adaptation to insulin resistance. JCI Insight. 2022 08 22; 7(16).
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Multiple myeloma cells induce lipolysis in adipocytes and uptake fatty acids through fatty acid transporter proteins. Blood. 2022 02 10; 139(6):876-888.
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Tyrosine phosphatases regulate resistance to ALK inhibitors in ALK+ anaplastic large cell lymphoma. Blood. 2022 02 03; 139(5):717-731.