Gene Rearrangement, B-Lymphocyte, Light Chain
"Gene Rearrangement, B-Lymphocyte, Light Chain" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Ordered rearrangement of B-lymphocyte variable gene regions coding for the kappa or lambda IMMUNOGLOBULIN LIGHT CHAINS, thereby contributing to antibody diversity. It occurs during the second stage of differentiation of the IMMATURE B-LYMPHOCYTES.
MeSH Number(s)
G05.355.330.401.601
G12.425.742.500.601
G12.500.349.500.601
Concept/Terms
Gene Rearrangement, B-Lymphocyte, Light Chain- Gene Rearrangement, B-Lymphocyte, Light Chain
- B-Cell Light Chain Gene Rearrangement
- B-Lymphocyte Light Chain Gene Rearrangement
- B Cell Light Chain Gene Rearrangement
- B Lymphocyte Light Chain Gene Rearrangement
Below are MeSH descriptors whose meaning is more general than "Gene Rearrangement, B-Lymphocyte, Light Chain".
Below are MeSH descriptors whose meaning is more specific than "Gene Rearrangement, B-Lymphocyte, Light Chain".
This graph shows the total number of publications written about "Gene Rearrangement, B-Lymphocyte, Light Chain" by people in Harvard Catalyst Profiles by year, and whether "Gene Rearrangement, B-Lymphocyte, Light Chain" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
---|
1996 | 1 | 0 | 1 |
1998 | 1 | 1 | 2 |
1999 | 2 | 1 | 3 |
2000 | 1 | 0 | 1 |
2001 | 0 | 1 | 1 |
2002 | 0 | 1 | 1 |
2004 | 0 | 1 | 1 |
2005 | 1 | 0 | 1 |
2007 | 1 | 0 | 1 |
Below are the most recent publications written about "Gene Rearrangement, B-Lymphocyte, Light Chain" by people in Profiles.
-
Epigenetic Enhancer Marks and Transcription Factor Binding Influence V? Gene Rearrangement in Pre-B Cells and Pro-B Cells. Front Immunol. 2018; 9:2074.
-
RAG-mediated DNA double-strand breaks activate a cell type-specific checkpoint to inhibit pre-B cell receptor signals. J Exp Med. 2016 Feb 08; 213(2):209-23.
-
Mantle cell lymphoma cell lines show no evident immunoglobulin heavy chain stereotypy but frequent light chain stereotypy. Leuk Lymphoma. 2013 Aug; 54(8):1747-55.
-
Quantification of ?-deleting recombination excision circles in Guthrie cards for the identification of early B-cell maturation defects. J Allergy Clin Immunol. 2011 Jul; 128(1):223-225.e2.
-
BCL6 is critical for the development of a diverse primary B cell repertoire. J Exp Med. 2010 Jun 07; 207(6):1209-21.
-
The epigenetic profile of Ig genes is dynamically regulated during B cell differentiation and is modulated by pre-B cell receptor signaling. J Immunol. 2009 Feb 01; 182(3):1362-9.
-
From gene amplification to V(D)J recombination and back: a personal account of my early years in B cell biology. Eur J Immunol. 2007 Nov; 37 Suppl 1:S138-47.
-
BASH-novel PKC-Raf-1 pathway of pre-BCR signaling induces kappa gene rearrangement. Blood. 2006 Oct 15; 108(8):2703-11.
-
In situ diversification of the antibody repertoire in chronic Lyme arthritis synovium. J Immunol. 2005 Mar 01; 174(5):2860-9.
-
Tracing the pre-B to immature B cell transition in human leukemia cells reveals a coordinated sequence of primary and secondary IGK gene rearrangement, IGK deletion, and IGL gene rearrangement. J Immunol. 2005 Jan 01; 174(1):367-75.