Sirtuin 2

"Sirtuin 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A sirtuin family member found primarily in the CYTOPLASM. It is a multifunctional enzyme that contains a NAD-dependent deacetylase activity that is specific for HISTONES and a mono-ADP-ribosyltransferase activity.

Descriptor ID

D056565

MeSH Number(s)

D08.811.277.087.520.200.650.200

D08.811.913.400.725.115.961.200

D12.776.476.900.200

Concept/Terms

Sirtuin 2

Below are MeSH descriptors whose meaning is more general than "Sirtuin 2".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Hydrolases [D08.811.277]
Amidohydrolases [D08.811.277.087]
Histone Deacetylases [D08.811.277.087.520]
Group III Histone Deacetylases [D08.811.277.087.520.200]
Sirtuins [D08.811.277.087.520.200.650]
Sirtuin 2 [D08.811.277.087.520.200.650.200]
Transferases [D08.811.913]
Glycosyltransferases [D08.811.913.400]
Pentosyltransferases [D08.811.913.400.725]
ADP Ribose Transferases [D08.811.913.400.725.115]
Sirtuins [D08.811.913.400.725.115.961]
Sirtuin 2 [D08.811.913.400.725.115.961.200]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Sirtuins [D12.776.476.900]
Sirtuin 2 [D12.776.476.900.200]

Below are MeSH descriptors whose meaning is related to "Sirtuin 2".

Below are MeSH descriptors whose meaning is more specific than "Sirtuin 2".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Sirtuin 2" by people in Harvard Catalyst Profiles by year, and whether "Sirtuin 2" was a major or minor topic of these publication.

Bar chart showing 64 publications over 25 distinct years, with a maximum of 5 publications in 2006

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	0	1	1
1997	0	1	1
1999	0	2	2
2000	0	2	2
2001	0	4	4
2002	0	4	4
2003	0	4	4
2004	0	3	3
2005	0	3	3
2006	0	5	5
2007	0	4	4
2008	0	1	1
2009	0	3	3
2010	2	0	2
2011	1	3	4
2012	2	0	2
2013	2	1	3
2014	4	0	4
2015	3	0	3
2016	1	1	2
2017	2	1	3
2019	1	0	1
2021	1	0	1
2022	1	0	1
2023	0	1	1

Below are the most recent publications written about "Sirtuin 2" by people in Profiles.

SIRT2 transgenic over-expression does not impact lifespan in mice. Aging Cell. 2023 Dec; 22(12):e14027.

View in: PubMed
Sirtuin 2 promotes human cytomegalovirus replication by regulating cell cycle progression. mSystems. 2023 Dec 21; 8(6):e0051023.

View in: PubMed
The deacetylase SIRT2 contributes to autoimmune disease pathogenesis by modulating IL-17A and IL-2 transcription. Cell Mol Immunol. 2022 06; 19(6):738-750.

View in: PubMed
SIRT2 regulates mitochondrial dynamics and reprogramming via MEK1-ERK-DRP1 and AKT1-DRP1 axes. Cell Rep. 2021 12 28; 37(13):110155.

View in: PubMed
NMT1 and NMT2 are lysine myristoyltransferases regulating the ARF6 GTPase cycle. Nat Commun. 2020 02 26; 11(1):1067.

View in: PubMed
Reduced SIRT1 and SIRT2 expression promotes adipogenesis of human visceral adipose stem cells and associates with accumulation of visceral fat in human obesity. Int J Obes (Lond). 2020 02; 44(2):307-319.

View in: PubMed
Novel Lysine-Based Thioureas as Mechanism-Based Inhibitors of Sirtuin 2 (SIRT2) with Anticancer Activity in a Colorectal Cancer Murine Model. J Med Chem. 2019 04 25; 62(8):4131-4141.

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Crucial Roles for SIRT2 and AMPA Receptor Acetylation in Synaptic Plasticity and Memory. Cell Rep. 2017 08 08; 20(6):1335-1347.

View in: PubMed
Metabolic control of primed human pluripotent stem cell fate and function by the miR-200c-SIRT2 axis. Nat Cell Biol. 2017 May; 19(5):445-456.

View in: PubMed
Mutations that Allow SIR2 Orthologs to Function in a NAD+-Depleted Environment. Cell Rep. 2017 03 07; 18(10):2310-2319.

View in: PubMed

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