"RNA Interference" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A gene silencing phenomenon whereby specific dsRNAs (RNA, DOUBLE-STRANDED) trigger the degradation of homologous mRNA (RNA, MESSENGER). The specific dsRNAs are processed into SMALL INTERFERING RNA (siRNA) which serves as a guide for cleavage of the homologous mRNA in the RNA-INDUCED SILENCING COMPLEX. DNA METHYLATION may also be triggered during this process.
Concept/Terms
RNA Interference- RNA Interference
- Interference, RNA
- Gene Silencing, Post-Transcriptional
- Gene Silencing, Post Transcriptional
- Post-Transcriptional Gene Silencings
- Silencing, Post-Transcriptional Gene
- Post-Transcriptional Gene Silencing
- Post Transcriptional Gene Silencing
- Posttranscriptional Gene Silencing
- Gene Silencing, Posttranscriptional
- Gene Silencings, Posttranscriptional
- RNA Silencing
Below are MeSH descriptors whose meaning is more general than "RNA Interference".
Below are MeSH descriptors whose meaning is more specific than "RNA Interference".
This graph shows the total number of publications written about "RNA Interference" by people in Harvard Catalyst Profiles by year, and whether "RNA Interference" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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2002 | 1 | 3 | 4 |
2003 | 12 | 25 | 37 |
2004 | 22 | 43 | 65 |
2005 | 40 | 62 | 102 |
2006 | 26 | 61 | 87 |
2007 | 24 | 61 | 85 |
2008 | 28 | 60 | 88 |
2009 | 25 | 61 | 86 |
2010 | 23 | 102 | 125 |
2011 | 22 | 111 | 133 |
2012 | 21 | 114 | 135 |
2013 | 29 | 111 | 140 |
2014 | 16 | 138 | 154 |
2015 | 26 | 126 | 152 |
2016 | 12 | 103 | 115 |
2017 | 20 | 104 | 124 |
2018 | 15 | 58 | 73 |
2019 | 5 | 51 | 56 |
2020 | 8 | 35 | 43 |
2021 | 5 | 25 | 30 |
2022 | 0 | 12 | 12 |
2023 | 0 | 4 | 4 |
2024 | 0 | 2 | 2 |
Below are the most recent publications written about "RNA Interference" by people in Profiles.
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RNA Interference With Zilebesiran for Mild to Moderate Hypertension: The KARDIA-1 Randomized Clinical Trial. JAMA. 2024 03 05; 331(9):740-749.
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Chemically Modified Platforms for Better RNA Therapeutics. Chem Rev. 2024 02 14; 124(3):929-1033.
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Zilebesiran for Hypertension. Reply. N Engl J Med. 2023 Oct 12; 389(15):1439-1440.
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Partial gene suppression improves identification of cancer vulnerabilities when CRISPR-Cas9 knockout is pan-lethal. Genome Biol. 2023 08 23; 24(1):192.
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Zilebesiran, an RNA Interference Therapeutic Agent for Hypertension. N Engl J Med. 2023 Jul 20; 389(3):228-238.
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Small RNAs >26 nt in length associate with AGO1 and are upregulated by nutrient deprivation in the alga Chlamydomonas. Plant Cell. 2023 05 29; 35(6):1868-1887.
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Hypoxia induces transgenerational epigenetic inheritance of small RNAs. Cell Rep. 2022 12 13; 41(11):111800.
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Short interfering RNA: a rapidly developing drug class. Eur Heart J. 2022 12 07; 43(46):4772-4774.
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An atypical RNA quadruplex marks RNAs as vectors for gene silencing. Nat Struct Mol Biol. 2022 11; 29(11):1113-1121.
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Anti-angiogenic properties of microRNA-29a in preclinical ocular models. Proc Natl Acad Sci U S A. 2022 11 08; 119(45):e2204795119.