Nuclear Receptor Subfamily 4, Group A, Member 1
"Nuclear Receptor Subfamily 4, Group A, Member 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An orphan nuclear receptor that is closely related to members of the thyroid-steroid receptor gene family. It was originally indentified in NERVE CELLS and may play a role in mediation of NERVE GROWTH FACTOR-induced CELL DIFFERENTIATION. However, several other functions have been attributed to this protein including the positive and negative regulation of APOPTOSIS.
MeSH Number(s)
D12.776.260.698.209.400
D12.776.826.209.400
D12.776.930.669.209.400
Concept/Terms
Nuclear Receptor Subfamily 4, Group A, Member 1- Nuclear Receptor Subfamily 4, Group A, Member 1
- Nerve Growth Factor-inducible B Protein
- Nerve Growth Factor inducible B Protein
- NGFI-B Orphan Nuclear Receptor
- NGFI B Orphan Nuclear Receptor
- Nuclear Receptor NR4A1
- Nur77 Orphan Nuclear Receptor
- Orphan Nuclear Receptor NGFI-B
- Orphan Nuclear Receptor NGFI B
- Orphan Nuclear Receptor NR4A1
- Orphan Nuclear Receptor TR3
- TR3 Orphan Nuclear Receptor
- Early Response Protein NAK1
- Orphan Nuclear Receptor HMR
Below are MeSH descriptors whose meaning is more general than "Nuclear Receptor Subfamily 4, Group A, Member 1".
- Chemicals and Drugs [D]
- Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
- DNA-Binding Proteins [D12.776.260]
- Receptors, Cytoplasmic and Nuclear [D12.776.260.698]
- Orphan Nuclear Receptors [D12.776.260.698.209]
- Nuclear Receptor Subfamily 4, Group A, Member 1 [D12.776.260.698.209.400]
- Receptors, Cytoplasmic and Nuclear [D12.776.826]
- Orphan Nuclear Receptors [D12.776.826.209]
- Nuclear Receptor Subfamily 4, Group A, Member 1 [D12.776.826.209.400]
- Transcription Factors [D12.776.930]
- Receptors, Cytoplasmic and Nuclear [D12.776.930.669]
- Orphan Nuclear Receptors [D12.776.930.669.209]
- Nuclear Receptor Subfamily 4, Group A, Member 1 [D12.776.930.669.209.400]
Below are MeSH descriptors whose meaning is more specific than "Nuclear Receptor Subfamily 4, Group A, Member 1".
This graph shows the total number of publications written about "Nuclear Receptor Subfamily 4, Group A, Member 1" by people in Harvard Catalyst Profiles by year, and whether "Nuclear Receptor Subfamily 4, Group A, Member 1" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 |
| 1998 | 0 | 1 | 1 |
| 2000 | 0 | 2 | 2 |
| 2002 | 0 | 1 | 1 |
| 2006 | 0 | 2 | 2 |
| 2007 | 0 | 1 | 1 |
| 2010 | 0 | 2 | 2 |
| 2011 | 1 | 0 | 1 |
| 2012 | 3 | 0 | 3 |
| 2013 | 1 | 1 | 2 |
| 2014 | 1 | 2 | 3 |
| 2015 | 1 | 0 | 1 |
| 2017 | 0 | 2 | 2 |
| 2018 | 2 | 0 | 2 |
| 2019 | 1 | 1 | 2 |
| 2020 | 2 | 1 | 3 |
| 2021 | 2 | 2 | 4 |
Below are the most recent publications written about "Nuclear Receptor Subfamily 4, Group A, Member 1" by people in Profiles.
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Resistance to inflammation underlies enhanced fitness in clonal hematopoiesis. Science. 2021 Nov 05; 374(6568):768-772.
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NR4A1 regulates expression of immediate early genes, suppressing replication stress in cancer. Mol Cell. 2021 10 07; 81(19):4041-4058.e15.
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A bacterial bile acid metabolite modulates Treg activity through the nuclear hormone receptor NR4A1. Cell Host Microbe. 2021 09 08; 29(9):1366-1377.e9.
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Landscape of innate lymphoid cells in human head and neck cancer reveals divergent NK cell states in the tumor microenvironment. Proc Natl Acad Sci U S A. 2021 07 13; 118(28).
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A Regulation Loop between YAP and NR4A1 Balances Cell Proliferation and Apoptosis. Cell Rep. 2020 10 20; 33(3):108284.
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Patrolling Monocytes Are Recruited and Activated by Diabetes to Protect Retinal Microvessels. Diabetes. 2020 12; 69(12):2709-2719.
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Targeting Oncogenic Super Enhancers in MYC-Dependent AML Using a Small Molecule Activator of NR4A Nuclear Receptors. Sci Rep. 2020 02 18; 10(1):2851.
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Adrenoceptor-related decrease in serum triglycerides is independent of PPARa activation. FEBS J. 2019 11; 286(21):4328-4341.
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Potent inhibition of breast cancer by bis-indole-derived nuclear receptor 4A1 (NR4A1) antagonists. Breast Cancer Res Treat. 2019 Aug; 177(1):29-40.
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DLL4 and Jagged1 are angiogenic targets of orphan nuclear receptor TR3/Nur77. Microvasc Res. 2019 07; 124:67-75.