Hypoxia-Inducible Factor 1, alpha Subunit
"Hypoxia-Inducible Factor 1, alpha Subunit" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Hypoxia-inducible factor 1, alpha subunit is a basic helix-loop-helix transcription factor that is regulated by OXYGEN availability and is targeted for degradation by VHL TUMOR SUPPRESSOR PROTEIN.
MeSH Number(s)
D12.776.260.103.625.750
D12.776.930.125.625.750
Below are MeSH descriptors whose meaning is more general than "Hypoxia-Inducible Factor 1, alpha Subunit".
Below are MeSH descriptors whose meaning is more specific than "Hypoxia-Inducible Factor 1, alpha Subunit".
This graph shows the total number of publications written about "Hypoxia-Inducible Factor 1, alpha Subunit" by people in Harvard Catalyst Profiles by year, and whether "Hypoxia-Inducible Factor 1, alpha Subunit" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 3 | 3 |
| 1996 | 0 | 2 | 2 |
| 1997 | 0 | 4 | 4 |
| 1998 | 0 | 5 | 5 |
| 1999 | 0 | 4 | 4 |
| 2000 | 0 | 6 | 6 |
| 2001 | 0 | 7 | 7 |
| 2002 | 0 | 14 | 14 |
| 2003 | 0 | 9 | 9 |
| 2004 | 1 | 25 | 26 |
| 2005 | 1 | 13 | 14 |
| 2006 | 9 | 4 | 13 |
| 2007 | 7 | 3 | 10 |
| 2008 | 6 | 0 | 6 |
| 2009 | 7 | 16 | 23 |
| 2010 | 14 | 11 | 25 |
| 2011 | 9 | 9 | 18 |
| 2012 | 5 | 11 | 16 |
| 2013 | 11 | 9 | 20 |
| 2014 | 16 | 5 | 21 |
| 2015 | 14 | 10 | 24 |
| 2016 | 17 | 14 | 31 |
| 2017 | 14 | 10 | 24 |
| 2018 | 17 | 12 | 29 |
| 2019 | 5 | 11 | 16 |
| 2020 | 12 | 9 | 21 |
| 2021 | 4 | 8 | 12 |
| 2022 | 1 | 7 | 8 |
| 2023 | 1 | 4 | 5 |
| 2024 | 1 | 0 | 1 |
Below are the most recent publications written about "Hypoxia-Inducible Factor 1, alpha Subunit" by people in Profiles.
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IL-17A Orchestrates Reactive Oxygen Species/HIF1a-Mediated Metabolic Reprogramming in Psoriasis. J Immunol. 2024 01 15; 212(2):302-316.
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Lactate limits CNS autoimmunity by stabilizing HIF-1a in dendritic cells. Nature. 2023 Aug; 620(7975):881-889.
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MYC overrides HIF-1a to regulate proliferating primary cell metabolism in hypoxia. Elife. 2023 07 10; 12.
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Targeting hypoxia-inducible factors with 32-134D safely and effectively treats diabetic eye disease in mice. J Clin Invest. 2023 07 03; 133(13).
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Prolonged hypoxia alleviates prolyl hydroxylation-mediated suppression of RIPK1 to promote necroptosis and inflammation. Nat Cell Biol. 2023 Jul; 25(7):950-962.
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IDH2 stabilizes HIF-1a-induced metabolic reprogramming and promotes chemoresistance in urothelial cancer. EMBO J. 2023 02 15; 42(4):e110620.
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HIF1A-dependent induction of alveolar epithelial PFKFB3 dampens acute lung injury. JCI Insight. 2022 12 22; 7(24).
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Microvascular remodeling and altered angiogenic signaling in human kidneys distal to occlusive atherosclerotic renal artery stenosis. Nephrol Dial Transplant. 2022 09 22; 37(10):1844-1856.
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USP13 promotes deubiquitination of ZHX2 and tumorigenesis in kidney cancer. Proc Natl Acad Sci U S A. 2022 09 06; 119(36):e2119854119.
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SF3B1 facilitates HIF1-signaling and promotes malignancy in pancreatic cancer. Cell Rep. 2022 08 23; 40(8):111266.