Nuclear Receptor Subfamily 2, Group C, Member 1
"Nuclear Receptor Subfamily 2, Group C, Member 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A DNA-binding orphan nuclear receptor that has specificity for directly repeated (DR) AGGTCA sequences. It binds DNA as either as a homodimer or as a heterodimer with the closely-related orphan nuclear receptor NUCLEAR RECEPTOR SUBFAMILY 2, GROUP C, MEMBER 2. The protein was originally identified as a PROSTATE-specific protein and is involved in the regulation of variety of cellular processes, including CELL DIFFERENTIATION; CELL PROLIFERATION; and APOPTOSIS.
MeSH Number(s)
D12.776.260.698.209.255
D12.776.826.209.255
D12.776.930.669.209.255
Concept/Terms
Nuclear Receptor Subfamily 2, Group C, Member 1- Nuclear Receptor Subfamily 2, Group C, Member 1
- Nuclear Receptor TR2
- Receptor TR2, Nuclear
- Orphan Nuclear Receptor TR2
- TR2-11 Receptor
- TR2 11 Receptor
- Nuclear Receptor NR2C1
- Orphan Nuclear Receptor NR2C1
Below are MeSH descriptors whose meaning is more general than "Nuclear Receptor Subfamily 2, Group C, Member 1".
- Chemicals and Drugs [D]
- Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
- DNA-Binding Proteins [D12.776.260]
- Receptors, Cytoplasmic and Nuclear [D12.776.260.698]
- Orphan Nuclear Receptors [D12.776.260.698.209]
- Nuclear Receptor Subfamily 2, Group C, Member 1 [D12.776.260.698.209.255]
- Receptors, Cytoplasmic and Nuclear [D12.776.826]
- Orphan Nuclear Receptors [D12.776.826.209]
- Nuclear Receptor Subfamily 2, Group C, Member 1 [D12.776.826.209.255]
- Transcription Factors [D12.776.930]
- Receptors, Cytoplasmic and Nuclear [D12.776.930.669]
- Orphan Nuclear Receptors [D12.776.930.669.209]
- Nuclear Receptor Subfamily 2, Group C, Member 1 [D12.776.930.669.209.255]
Below are MeSH descriptors whose meaning is more specific than "Nuclear Receptor Subfamily 2, Group C, Member 1".
This graph shows the total number of publications written about "Nuclear Receptor Subfamily 2, Group C, Member 1" by people in Harvard Catalyst Profiles by year, and whether "Nuclear Receptor Subfamily 2, Group C, Member 1" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2011 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
Below are the most recent publications written about "Nuclear Receptor Subfamily 2, Group C, Member 1" by people in Profiles.
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The nuclear hormone receptor gene Nr2c1 (Tr2) is a critical regulator of early retina cell patterning. Dev Biol. 2017 09 01; 429(1):343-355.
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Forced TR2/TR4 expression in sickle cell disease mice confers enhanced fetal hemoglobin synthesis and alleviated disease phenotypes. Proc Natl Acad Sci U S A. 2011 Nov 15; 108(46):18808-13.
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Embryonic and fetal beta-globin gene repression by the orphan nuclear receptors, TR2 and TR4. EMBO J. 2007 May 02; 26(9):2295-306.
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Molecular cloning and characterization of chicken orphan nuclear receptor cTR2. Gen Comp Endocrinol. 2003 Jul; 132(3):474-84.