Nuclear Receptor Subfamily 4, Group A, Member 2
"Nuclear Receptor Subfamily 4, Group A, Member 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An orphan nuclear receptor that is found at high levels in BRAIN tissue. The protein is believed to play a role in development and maintenance of NEURONS, particularly dopaminergic neurons.
MeSH Number(s)
D12.776.260.698.209.415
D12.776.826.209.415
D12.776.930.669.209.415
Concept/Terms
Nuclear Receptor Subfamily 4, Group A, Member 2- Nuclear Receptor Subfamily 4, Group A, Member 2
- Nuclear Receptor-Related Factor 1
- Nuclear Receptor Related Factor 1
- Nurr1 Nuclear Receptor
- Orphan Nuclear Receptor Nurr1
- Nuclear Receptor NR4A2
- NR4A2, Nuclear Receptor
- Receptor NR4A2, Nuclear
- Nur-Related Factor 1
- 1, Nur-Related Factor
- Factor 1, Nur-Related
- Nur Related Factor 1
Below are MeSH descriptors whose meaning is more general than "Nuclear Receptor Subfamily 4, Group A, Member 2".
- Chemicals and Drugs [D]
- Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
- DNA-Binding Proteins [D12.776.260]
- Receptors, Cytoplasmic and Nuclear [D12.776.260.698]
- Orphan Nuclear Receptors [D12.776.260.698.209]
- Nuclear Receptor Subfamily 4, Group A, Member 2 [D12.776.260.698.209.415]
- Receptors, Cytoplasmic and Nuclear [D12.776.826]
- Orphan Nuclear Receptors [D12.776.826.209]
- Nuclear Receptor Subfamily 4, Group A, Member 2 [D12.776.826.209.415]
- Transcription Factors [D12.776.930]
- Receptors, Cytoplasmic and Nuclear [D12.776.930.669]
- Orphan Nuclear Receptors [D12.776.930.669.209]
- Nuclear Receptor Subfamily 4, Group A, Member 2 [D12.776.930.669.209.415]
Below are MeSH descriptors whose meaning is more specific than "Nuclear Receptor Subfamily 4, Group A, Member 2".
This graph shows the total number of publications written about "Nuclear Receptor Subfamily 4, Group A, Member 2" by people in Harvard Catalyst Profiles by year, and whether "Nuclear Receptor Subfamily 4, Group A, Member 2" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 |
| 2002 | 0 | 3 | 3 |
| 2003 | 0 | 2 | 2 |
| 2004 | 0 | 2 | 2 |
| 2005 | 0 | 3 | 3 |
| 2006 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2009 | 0 | 3 | 3 |
| 2010 | 1 | 0 | 1 |
| 2014 | 3 | 0 | 3 |
| 2015 | 3 | 1 | 4 |
| 2018 | 2 | 0 | 2 |
| 2019 | 1 | 0 | 1 |
| 2020 | 1 | 1 | 2 |
| 2023 | 0 | 1 | 1 |
Below are the most recent publications written about "Nuclear Receptor Subfamily 4, Group A, Member 2" by people in Profiles.
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An optimized Nurr1 agonist provides disease-modifying effects in Parkinson's disease models. Nat Commun. 2023 07 18; 14(1):4283.
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Regulation of CCR4-NOT complex deadenylase activity and cellular responses by MK2-dependent phosphorylation of CNOT2. RNA Biol. 2022; 19(1):234-246.
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PGE1 and PGA1 bind to Nurr1 and activate its transcriptional function. Nat Chem Biol. 2020 08; 16(8):876-886.
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De novo variants of NR4A2 are associated with neurodevelopmental disorder and epilepsy. Genet Med. 2020 08; 22(8):1413-1417.
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Chloroquine modulates inflammatory autoimmune responses through Nurr1 in autoimmune diseases. Sci Rep. 2019 10 29; 9(1):15559.
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Nurr1 (NR4A2) regulates Alzheimer's disease-related pathogenesis and cognitive function in the 5XFAD mouse model. Aging Cell. 2019 02; 18(1):e12866.
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HX600, a synthetic agonist for RXR-Nurr1 heterodimer complex, prevents ischemia-induced neuronal damage. Brain Behav Immun. 2018 10; 73:670-681.
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Directed Differentiation of Dopamine-Secreting Cells from Nurr1/GPX1 Expressing Murine Embryonic Stem Cells Cultured on Matrigel-Coated PCL Scaffolds. Mol Neurobiol. 2017 03; 54(2):1119-1128.
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Parathyroid hormone 1 receptor is essential to induce FGF23 production and maintain systemic mineral ion homeostasis. FASEB J. 2016 Jan; 30(1):428-40.
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Production of Nurr-1 Specific Polyclonal Antibodies Free of Cross-reactivity Against Its Close Homologs, Nor1 and Nur77. J Vis Exp. 2015 Aug 17; (102):e52963.