Nuclear Receptor Subfamily 2, Group C, Member 2
"Nuclear Receptor Subfamily 2, Group C, Member 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An orphan nuclear receptor that has specificity for hormone response elements found in the promoters of target genes. It binds DNA either as a homodimer or as heterodimer with the closely-related orphan nuclear receptor NUCLEAR RECEPTOR SUBFAMILY 2, GROUP C, MEMBER 1. The protein was originally identified as a TESTES-specific protein and is involved in the regulation of variety of cellular processes, including CELL DIFFERENTIATION; CELL PROLIFERATION; and APOPTOSIS.
MeSH Number(s)
D12.776.260.698.209.327
D12.776.826.209.327
D12.776.930.669.209.327
Concept/Terms
Nuclear Receptor Subfamily 2, Group C, Member 2- Nuclear Receptor Subfamily 2, Group C, Member 2
- TR4 Nuclear Hormone Receptor
- TAK1 Receptor
- Receptor, TAK1
- Nuclear Receptor NR2C2
- NR2C2, Nuclear Receptor
- Orphan Nuclear Receptor TR4
- Testicular Receptor 4
Below are MeSH descriptors whose meaning is more general than "Nuclear Receptor Subfamily 2, Group C, Member 2".
- Chemicals and Drugs [D]
- Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
- DNA-Binding Proteins [D12.776.260]
- Receptors, Cytoplasmic and Nuclear [D12.776.260.698]
- Orphan Nuclear Receptors [D12.776.260.698.209]
- Nuclear Receptor Subfamily 2, Group C, Member 2 [D12.776.260.698.209.327]
- Receptors, Cytoplasmic and Nuclear [D12.776.826]
- Orphan Nuclear Receptors [D12.776.826.209]
- Nuclear Receptor Subfamily 2, Group C, Member 2 [D12.776.826.209.327]
- Transcription Factors [D12.776.930]
- Receptors, Cytoplasmic and Nuclear [D12.776.930.669]
- Orphan Nuclear Receptors [D12.776.930.669.209]
- Nuclear Receptor Subfamily 2, Group C, Member 2 [D12.776.930.669.209.327]
Below are MeSH descriptors whose meaning is more specific than "Nuclear Receptor Subfamily 2, Group C, Member 2".
This graph shows the total number of publications written about "Nuclear Receptor Subfamily 2, Group C, Member 2" by people in Harvard Catalyst Profiles by year, and whether "Nuclear Receptor Subfamily 2, Group C, Member 2" was a major or minor topic of these publication.
To see the data from this visualization as text,
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Year | Major Topic | Minor Topic | Total |
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2011 | 2 | 0 | 2 |
Below are the most recent publications written about "Nuclear Receptor Subfamily 2, Group C, Member 2" by people in Profiles.
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Forced TR2/TR4 expression in sickle cell disease mice confers enhanced fetal hemoglobin synthesis and alleviated disease phenotypes. Proc Natl Acad Sci U S A. 2011 Nov 15; 108(46):18808-13.
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Increased acetylation in the DNA-binding domain of TR4 nuclear receptor by the coregulator ARA55 leads to suppression of TR4 transactivation. J Biol Chem. 2011 Jun 17; 286(24):21129-36.