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Alberto Serrano-Pozo, Ph.D., M.D.

Title
Institution
Department
Address
Phone
Profile Picture

Biography
Massachusetts General Hospital, Boston06/2018Fellowship in Clinical Dementias
University of Iowa, Iowa cityNeurologist06/2017Neurology Residency
Massachusetts General Hospital & University of Seville, Boston and Seville (Spain)PhD04/2013Neuropathology of Alzheimer's disease
University Hospital Virgen del Rocío, Seville (Spain)06/2008Behavioral Neurology fellowship
University Hospital Virgen del Rocío, Seville (Spain)Neurologist06/2006Neurology Residency
University of Málaga School of Medicine, Málaga (Spain)MD06/2001Medicine
2016 - 2017
Best Teacher Senior Resident
2016 - 2017
Chief Resident
2015 - 2016
Best Teacher Senior Resident
2012 - 2013
Extraordinary Doctorate Thesis in Health Sciences Award
2010 - 2010
Best Original Article of the Year on Dementias by a Spanish Neurologist
1995 - 2001
"Best In Class" (XXV Class)

Overview
Dr. Serrano-Pozo is originally from Málaga, Spain. He received his MD in 2001 at the University of Málaga School of Medicine and completed his neurology residency in 2006 at the University Hospital Virgen del Rocío in Seville (Spain), followed by a 2-year research and behavioral neurology fellowship at the same institution. He first joined Dr. Bradley Hyman’s lab at MGH as a research fellow in 2008, where he investigated clinic-pathological correlations of Alzheimer’s dementia using brain specimens from the Massachusetts Alzheimer’s Disease Research Center brain bank, as well as the National Alzheimer’s Coordinating Center (NACC) database. His publications during this period resulted in Dr. Serrano-Pozo obtaining his PhD at the University of Seville in 2013. Next, he pursued a US neurology residency, which he completed at the University of Iowa in 2017 as Chief Resident, before returning to MGH.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. AACF (Bradley T. Hyman) Jul 1, 2017 - Jun 30, 2019
    Alzheimer's Association
    Transcriptomic Changes of Astrocytes in Alzheimer's Disease
    Role: Co-Investigator
  2. R25 (Bradley T. Hyman) Jul 1, 2017 - Dec 31, 2018
    NINDS
    Deciphering the Astrocyte Reaction in Alzheimer's Disease
    Role: Mentee
  3. Research Fellowship (Bradley T. Hyman) Jan 1, 2010 - Dec 31, 2011
    Fundación Alfonso Martín Escudero, Madrid (Spain)
    A Neuropathological Approach to the Pathophysiology of Alzheimer's disease
    Role: Mentee
  4. Research Fellowship (José López-Barneo & Bradley T. Hyman) Jan 1, 2007 - Dec 31, 2008
    Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación, Madrid (Spain)
    Effects of Hypoxia on Alzheimer's Disease / A Neuropathological Approach to the Pathophysiology of Alzheimer's Disease
    Role: Mentee

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Gui Y, Marks JD, Das S, Hyman BT, Serrano-Pozo A. Characterization of the 18 kda translocator protein (tspo) expression in post-mortem normal and alzheimer's disease brains. Brain Pathol. 2019 Jul 05. PMID: 31276244.
    Citations:    
  2. Pérez-Nievas BG, Serrano-Pozo A. Editorial: The Role of Glia in Alzheimer's Disease. Front Neurol. 2018; 9:1161. PMID: 30692961.
    Citations:    
  3. Serrano-Pozo A, Growdon JH. Is Alzheimer's Disease Risk Modifiable? J Alzheimers Dis. 2019; 67(3):795-819. PMID: 30776012.
    Citations:    
  4. Perez-Nievas BG, Serrano-Pozo A. Deciphering the Astrocyte Reaction in Alzheimer's Disease. Front Aging Neurosci. 2018; 10:114. PMID: 29922147.
    Citations: 1     
  5. Serrano-Pozo A, Sánchez-García MA, Heras-Garvín A, March-Díaz R, Navarro V, Vizuete M, López-Barneo J, Vitorica J, Pascual A. Acute and Chronic Sustained Hypoxia Do Not Substantially Regulate Amyloid-ß Peptide Generation In Vivo. PLoS One. 2017; 12(1):e0170345. PMID: 28099462.
    Citations: 1     Fields:    Translation:AnimalsCells
  6. Serrano-Pozo A, Aldridge GM, Zhang Q. Four Decades of Research in Alzheimer's Disease (1975-2014): A Bibliometric and Scientometric Analysis. J Alzheimers Dis. 2017; 59(2):763-783. PMID: 28671119.
    Citations:    Fields:    Translation:Humans
  7. Serrano-Pozo A, Qian J, Muzikansky A, Monsell SE, Montine TJ, Frosch MP, Betensky RA, Hyman BT. Thal Amyloid Stages Do Not Significantly Impact the Correlation Between Neuropathological Change and Cognition in the Alzheimer Disease Continuum. J Neuropathol Exp Neurol. 2016 06; 75(6):516-26. PMID: 27105663.
    Citations: 5     Fields:    Translation:HumansCells
  8. Serrano-Pozo A, Betensky RA, Frosch MP, Hyman BT. Plaque-Associated Local Toxicity Increases over the Clinical Course of Alzheimer Disease. Am J Pathol. 2016 Feb; 186(2):375-84. PMID: 26687817.
    Citations: 9     Fields:    Translation:HumansCells
  9. Serrano-Pozo A, Hyman BT. Alzheimer disease: Alzheimer dementia with sparse amyloid-AD mimic or variant? Nat Rev Neurol. 2015 Dec; 11(12):674-5. PMID: 26553593.
    Citations: 1     Fields:    Translation:Humans
  10. Bachhuber T, Katzmarski N, McCarter JF, Loreth D, Tahirovic S, Kamp F, Abou-Ajram C, Nuscher B, Serrano-Pozo A, Müller A, Prinz M, Steiner H, Hyman BT, Haass C, Meyer-Luehmann M. Inhibition of amyloid-ß plaque formation by a-synuclein. Nat Med. 2015 Jul; 21(7):802-7. PMID: 26099047.
    Citations: 18     Fields:    Translation:HumansAnimals
  11. von Einem B, Wahler A, Schips T, Serrano-Pozo A, Proepper C, Boeckers TM, Rueck A, Wirth T, Hyman BT, Danzer KM, Thal DR, von Arnim CA. The Golgi-Localized ?-Ear-Containing ARF-Binding (GGA) Proteins Alter Amyloid-ß Precursor Protein (APP) Processing through Interaction of Their GAE Domain with the Beta-Site APP Cleaving Enzyme 1 (BACE1). PLoS One. 2015; 10(6):e0129047. PMID: 26053850.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  12. Serrano-Pozo A, Qian J, Monsell SE, Betensky RA, Hyman BT. APOEe2 is associated with milder clinical and pathological Alzheimer disease. Ann Neurol. 2015 Jun; 77(6):917-29. PMID: 25623662.
    Citations: 20     Fields:    Translation:Humans
  13. Jellinger KA, Alafuzoff I, Attems J, Beach TG, Cairns NJ, Crary JF, Dickson DW, Hof PR, Hyman BT, Jack CR, Jicha GA, Knopman DS, Kovacs GG, Mackenzie IR, Masliah E, Montine TJ, Nelson PT, Schmitt F, Schneider JA, Serrano-Pozo A, Thal DR, Toledo JB, Trojanowski JQ, Troncoso JC, Vonsattel JP, Wisniewski T. PART, a distinct tauopathy, different from classical sporadic Alzheimer disease. Acta Neuropathol. 2015 May; 129(5):757-62. PMID: 25778618.
    Citations: 29     Fields:    Translation:Humans
  14. Crary JF, Trojanowski JQ, Schneider JA, Abisambra JF, Abner EL, Alafuzoff I, Arnold SE, Attems J, Beach TG, Bigio EH, Cairns NJ, Dickson DW, Gearing M, Grinberg LT, Hof PR, Hyman BT, Jellinger K, Jicha GA, Kovacs GG, Knopman DS, Kofler J, Kukull WA, Mackenzie IR, Masliah E, McKee A, Montine TJ, Murray ME, Neltner JH, Santa-Maria I, Seeley WW, Serrano-Pozo A, Shelanski ML, Stein T, Takao M, Thal DR, Toledo JB, Troncoso JC, Vonsattel JP, White CL, Wisniewski T, Woltjer RL, Yamada M, Nelson PT. Primary age-related tauopathy (PART): a common pathology associated with human aging. Acta Neuropathol. 2014 Dec; 128(6):755-66. PMID: 25348064.
    Citations: 183     Fields:    Translation:Humans
  15. Tai HC, Wang BY, Serrano-Pozo A, Frosch MP, Spires-Jones TL, Hyman BT. Frequent and symmetric deposition of misfolded tau oligomers within presynaptic and postsynaptic terminals in Alzheimer's disease. Acta Neuropathol Commun. 2014 Oct 21; 2:146. PMID: 25330988.
    Citations: 25     Fields:    Translation:HumansCells
  16. Serrano-Pozo A, Qian J, Monsell SE, Blacker D, Gómez-Isla T, Betensky RA, Growdon JH, Johnson KA, Frosch MP, Sperling RA, Hyman BT. Mild to moderate Alzheimer dementia with insufficient neuropathological changes. Ann Neurol. 2014 Apr; 75(4):597-601. PMID: 24585367.
    Citations: 20     Fields:    Translation:Humans
  17. Serrano-Pozo A, Qian J, Monsell SE, Frosch MP, Betensky RA, Hyman BT. Examination of the clinicopathologic continuum of Alzheimer disease in the autopsy cohort of the National Alzheimer Coordinating Center. J Neuropathol Exp Neurol. 2013 Dec; 72(12):1182-92. PMID: 24226270.
    Citations: 33     Fields:    Translation:Humans
  18. Suárez-González A, Serrano-Pozo A, Arroyo-Anlló EM, Franco-Macías E, Polo J, García-Solís D, Gil-Néciga E. Utility of neuropsychiatric tools in the differential diagnosis of dementia with Lewy bodies and Alzheimer's disease: quantitative and qualitative findings. Int Psychogeriatr. 2014 Mar; 26(3):453-61. PMID: 24284139.
    Citations: 7     Fields:    Translation:Humans
  19. Xie H, Guan J, Borrelli LA, Xu J, Serrano-Pozo A, Bacskai BJ. Mitochondrial alterations near amyloid plaques in an Alzheimer's disease mouse model. J Neurosci. 2013 Oct 23; 33(43):17042-51. PMID: 24155308.
    Citations: 42     Fields:    Translation:AnimalsCells
  20. Maguire CA, Crommentuijn MH, Mu D, Hudry E, Serrano-Pozo A, Hyman BT, Tannous BA. Mouse gender influences brain transduction by intravascularly administered AAV9. Mol Ther. 2013 Aug; 21(8):1470-1. PMID: 23903572.
    Citations: 11     Fields:    Translation:AnimalsCells
  21. Perez-Nievas BG, Stein TD, Tai HC, Dols-Icardo O, Scotton TC, Barroeta-Espar I, Fernandez-Carballo L, de Munain EL, Perez J, Marquie M, Serrano-Pozo A, Frosch MP, Lowe V, Parisi JE, Petersen RC, Ikonomovic MD, López OL, Klunk W, Hyman BT, Gómez-Isla T. Dissecting phenotypic traits linked to human resilience to Alzheimer's pathology. Brain. 2013 Aug; 136(Pt 8):2510-26. PMID: 23824488.
    Citations: 68     Fields:    Translation:HumansCells
  22. Kay KR, Smith C, Wright AK, Serrano-Pozo A, Pooler AM, Koffie R, Bastin ME, Bak TH, Abrahams S, Kopeikina KJ, McGuone D, Frosch MP, Gillingwater TH, Hyman BT, Spires-Jones TL. Studying synapses in human brain with array tomography and electron microscopy. Nat Protoc. 2013; 8(7):1366-80. PMID: 23787894.
    Citations: 19     Fields:    Translation:HumansCells
  23. Serrano-Pozo A, Muzikansky A, Gómez-Isla T, Growdon JH, Betensky RA, Frosch MP, Hyman BT. Differential relationships of reactive astrocytes and microglia to fibrillar amyloid deposits in Alzheimer disease. J Neuropathol Exp Neurol. 2013 Jun; 72(6):462-71. PMID: 23656989.
    Citations: 32     Fields:    Translation:HumansCells
  24. Griciuc A, Serrano-Pozo A, Parrado AR, Lesinski AN, Asselin CN, Mullin K, Hooli B, Choi SH, Hyman BT, Tanzi RE. Alzheimer's disease risk gene CD33 inhibits microglial uptake of amyloid beta. Neuron. 2013 May 22; 78(4):631-43. PMID: 23623698.
    Citations: 193     Fields:    Translation:HumansAnimalsCells
  25. Serrano-Pozo A, Gómez-Isla T, Growdon JH, Frosch MP, Hyman BT. A phenotypic change but not proliferation underlies glial responses in Alzheimer disease. Am J Pathol. 2013 Jun; 182(6):2332-44. PMID: 23602650.
    Citations: 28     Fields:    Translation:HumansCells
  26. Wahlster L, Arimon M, Nasser-Ghodsi N, Post KL, Serrano-Pozo A, Uemura K, Berezovska O. Presenilin-1 adopts pathogenic conformation in normal aging and in sporadic Alzheimer's disease. Acta Neuropathol. 2013 Feb; 125(2):187-99. PMID: 23138650.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  27. Hashimoto T, Serrano-Pozo A, Hori Y, Adams KW, Takeda S, Banerji AO, Mitani A, Joyner D, Thyssen DH, Bacskai BJ, Frosch MP, Spires-Jones TL, Finn MB, Holtzman DM, Hyman BT. Apolipoprotein E, especially apolipoprotein E4, increases the oligomerization of amyloid ß peptide. J Neurosci. 2012 Oct 24; 32(43):15181-92. PMID: 23100439.
    Citations: 49     Fields:    Translation:HumansCells
  28. Tai HC, Serrano-Pozo A, Hashimoto T, Frosch MP, Spires-Jones TL, Hyman BT. The synaptic accumulation of hyperphosphorylated tau oligomers in Alzheimer disease is associated with dysfunction of the ubiquitin-proteasome system. Am J Pathol. 2012 Oct; 181(4):1426-35. PMID: 22867711.
    Citations: 81     Fields:    Translation:HumansAnimalsCells
  29. Serrano-Pozo A, Mielke ML, Muzitansky A, Gómez-Isla T, Growdon JH, Bacskai BJ, Betensky RA, Frosch MP, Hyman BT. Stable size distribution of amyloid plaques over the course of Alzheimer disease. J Neuropathol Exp Neurol. 2012 Aug; 71(8):694-701. PMID: 22805771.
    Citations: 10     Fields:    Translation:Humans
  30. Koffie RM, Hashimoto T, Tai HC, Kay KR, Serrano-Pozo A, Joyner D, Hou S, Kopeikina KJ, Frosch MP, Lee VM, Holtzman DM, Hyman BT, Spires-Jones TL. Apolipoprotein E4 effects in Alzheimer's disease are mediated by synaptotoxic oligomeric amyloid-ß. Brain. 2012 Jul; 135(Pt 7):2155-68. PMID: 22637583.
    Citations: 71     Fields:    Translation:HumansCells
  31. Serrano-Pozo A, Frosch MP, Masliah E, Hyman BT. Neuropathological alterations in Alzheimer disease. Cold Spring Harb Perspect Med. 2011 Sep; 1(1):a006189. PMID: 22229116.
    Citations: 339     Fields:    Translation:HumansCells
  32. Serrano-Pozo A, Mielke ML, Gómez-Isla T, Betensky RA, Growdon JH, Frosch MP, Hyman BT. Reactive glia not only associates with plaques but also parallels tangles in Alzheimer's disease. Am J Pathol. 2011 Sep; 179(3):1373-84. PMID: 21777559.
    Citations: 59     Fields:    Translation:HumansCells
  33. DaRocha-Souto B, Scotton TC, Coma M, Serrano-Pozo A, Hashimoto T, Serenó L, Rodríguez M, Sánchez B, Hyman BT, Gómez-Isla T. Brain oligomeric ß-amyloid but not total amyloid plaque burden correlates with neuronal loss and astrocyte inflammatory response in amyloid precursor protein/tau transgenic mice. J Neuropathol Exp Neurol. 2011 May; 70(5):360-76. PMID: 21487307.
    Citations: 29     Fields:    Translation:AnimalsCells
  34. Serrano-Pozo A, Vega GL, Lütjohann D, Locascio JJ, Tennis MK, Deng A, Atri A, Hyman BT, Irizarry MC, Growdon JH. Effects of simvastatin on cholesterol metabolism and Alzheimer disease biomarkers. Alzheimer Dis Assoc Disord. 2010 Jul-Sep; 24(3):220-6. PMID: 20473136.
    Citations: 13     Fields:    Translation:HumansCTClinical Trials
  35. Serrano-Pozo A, William CM, Ferrer I, Uro-Coste E, Delisle MB, Maurage CA, Hock C, Nitsch RM, Masliah E, Growdon JH, Frosch MP, Hyman BT. Beneficial effect of human anti-amyloid-beta active immunization on neurite morphology and tau pathology. Brain. 2010 May; 133(Pt 5):1312-27. PMID: 20360050.
    Citations: 55     Fields:    Translation:HumansCellsPHPublic HealthCTClinical Trials
  36. Serrano-Pozo A, Gómez-Isla T. Patogenia y Fisiopatología. In: Román Alberca, Secundino López-Pousa. Enfermedad de Alzheimer y otras demencias. 2010.
  37. González Pérez P, Serrano-Pozo A, Franco-Macías E, Montes-Latorre E, Gómez-Aranda F, Campos T. Vincristine-induced acute neurotoxicity versus Guillain-Barré syndrome: a diagnostic dilemma. Eur J Neurol. 2007 Jul; 14(7):826-8. PMID: 17594344.
    Citations: 4     Fields:    Translation:Humans
  38. Serrano-Pozo A, Montes-Latorre E, González-Marcos JR, Gil-Peralta A. Cardiac embolism in a Claude's syndrome without involvement of the red nucleus. Eur J Neurol. 2007 Feb; 14(2):e1-2. PMID: 17250704.
    Citations:    Fields:    Translation:Humans
  39. Serrano-Pozo A, Nevado-Portero J, Sanz-Fernández G, Martínez-Fernández E. Neurological picture. Spinal anterior artery territory infarction simulating an acute myocardial infarction. J Neurol Neurosurg Psychiatry. 2005 Nov; 76(11):1584. PMID: 16227557.
    Citations: 1     Fields:    Translation:Humans
  40. Serrano-Pozo A, Gómez-Aranda F, Giles M, Chinchón D, Chinchón I, Bautista-Lorite J. Sensory polyneuropathy as initial manifestation of endemic leprosy in Spain. Eur Neurol. 2004; 52(4):256-8. PMID: 15583462.
    Citations:    Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.