"Neurofibrillary Tangles" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Abnormal structures located in various parts of the brain and composed of dense arrays of paired helical filaments (neurofilaments and microtubules). These double helical stacks of transverse subunits are twisted into left-handed ribbon-like filaments that likely incorporate the following proteins: (1) the intermediate filaments: medium- and high-molecular-weight neurofilaments; (2) the microtubule-associated proteins map-2 and tau; (3) actin; and (4) UBIQUITINS. As one of the hallmarks of ALZHEIMER DISEASE, the neurofibrillary tangles eventually occupy the whole of the cytoplasm in certain classes of cell in the neocortex, hippocampus, brain stem, and diencephalon. The number of these tangles, as seen in post mortem histology, correlates with the degree of dementia during life. Some studies suggest that tangle antigens leak into the systemic circulation both in the course of normal aging and in cases of Alzheimer disease.
MeSH Number(s)
A08.663.609.520
A11.284.430.214.190.750.640.520
A11.671.573.520
Concept/Terms
Neurofibrillary Tangles- Neurofibrillary Tangles
- Neurofibrillary Tangle
- Tangle, Neurofibrillary
- Tangles, Neurofibrillary
Below are MeSH descriptors whose meaning is more general than "Neurofibrillary Tangles".
Below are MeSH descriptors whose meaning is more specific than "Neurofibrillary Tangles".
This graph shows the total number of publications written about "Neurofibrillary Tangles" by people in Harvard Catalyst Profiles by year, and whether "Neurofibrillary Tangles" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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1994 | 3 | 10 | 13 |
1995 | 4 | 3 | 7 |
1996 | 3 | 9 | 12 |
1997 | 4 | 8 | 12 |
1998 | 1 | 6 | 7 |
1999 | 5 | 4 | 9 |
2000 | 2 | 6 | 8 |
2001 | 1 | 5 | 6 |
2002 | 3 | 4 | 7 |
2003 | 6 | 6 | 12 |
2004 | 2 | 1 | 3 |
2005 | 3 | 4 | 7 |
2006 | 3 | 10 | 13 |
2007 | 2 | 1 | 3 |
2008 | 3 | 6 | 9 |
2009 | 1 | 2 | 3 |
2010 | 6 | 4 | 10 |
2011 | 6 | 7 | 13 |
2012 | 0 | 8 | 8 |
2013 | 3 | 5 | 8 |
2014 | 2 | 2 | 4 |
2015 | 3 | 4 | 7 |
2016 | 6 | 2 | 8 |
2017 | 9 | 5 | 14 |
2018 | 4 | 8 | 12 |
2019 | 2 | 2 | 4 |
2020 | 2 | 8 | 10 |
2021 | 1 | 8 | 9 |
2022 | 1 | 7 | 8 |
2023 | 0 | 8 | 8 |
2024 | 1 | 0 | 1 |
Below are the most recent publications written about "Neurofibrillary Tangles" by people in Profiles.
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Alzheimer proteopathic tau seeds are biochemically a forme fruste of mature paired helical filaments. Brain. 2024 02 01; 147(2):637-648.
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Reconstitution of the Alzheimer's Disease Tau Core Structure from Recombinant Tau297-391 Yields Variable Quaternary Structures as Seen by Negative Stain and Cryo-EM. Biochemistry. 2024 Jan 16; 63(2):194-201.
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Cell-type-specific Alzheimer's disease polygenic risk scores are associated with distinct disease processes in Alzheimer's disease. Nat Commun. 2023 Nov 30; 14(1):7659.
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Distinct transcriptomic responses to Aß plaques, neurofibrillary tangles, and APOE in Alzheimer's disease. Alzheimers Dement. 2024 Jan; 20(1):74-90.
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Tau seeding and spreading in vivo is supported by both AD-derived fibrillar and oligomeric tau. Acta Neuropathol. 2023 08; 146(2):191-210.
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Correlating continuously captured home-based digital biomarkers of daily function with postmortem neurodegenerative neuropathology. PLoS One. 2023; 18(6):e0286812.
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Bioinformatic analysis of the SPs and NFTs proteomes unravel putative biomarker candidates for Alzheimer's disease. Proteomics. 2023 Aug; 23(15):e2200515.
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Estrogen Receptor Genes, Cognitive Decline, and Alzheimer Disease. Neurology. 2023 04 04; 100(14):e1474-e1487.
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Alzheimer's Disease Pathology Outside of the Cerebrum Is Related to a Higher Odds of Dementia. J Alzheimers Dis. 2023; 96(2):563-578.
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All the Tau We Cannot See. Annu Rev Med. 2023 01 27; 74:503-514.