Complement C6

"Complement C6" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A 105-kDa serum glycoprotein with significant homology to the other late complement components, C7-C9. It is a polypeptide chain cross-linked by 32 disulfide bonds. C6 is the next complement component to bind to the membrane-bound COMPLEMENT C5B in the assembly of MEMBRANE ATTACK COMPLEX. It is encoded by gene C6.

Descriptor ID

D003183

MeSH Number(s)

D12.776.124.486.274.550

Concept/Terms

Complement C6

Below are MeSH descriptors whose meaning is more general than "Complement C6".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Blood Proteins [D12.776.124]
Immunoproteins [D12.776.124.486]
Complement System Proteins [D12.776.124.486.274]
Complement C6 [D12.776.124.486.274.550]

Below are MeSH descriptors whose meaning is related to "Complement C6".

Below are MeSH descriptors whose meaning is more specific than "Complement C6".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Complement C6" by people in Harvard Catalyst Profiles by year, and whether "Complement C6" was a major or minor topic of these publication.

Bar chart showing 7 publications over 6 distinct years, with a maximum of 2 publications in 2011

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1999	1	0	1
2006	0	1	1
2011	1	1	2
2012	0	1	1
2013	0	1	1
2018	1	0	1

Below are the most recent publications written about "Complement C6" by people in Profiles.

Higher C6 enzyme immunoassay index values correlate with a diagnosis of noncutaneous Lyme disease. Diagn Microbiol Infect Dis. 2019 Jun; 94(2):160-164.

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C5a receptor (CD88) blockade protects against MPO-ANCA GN. J Am Soc Nephrol. 2014 Feb; 25(2):225-31.

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The alternative complement pathway propagates inflammation and injury in murine ischemic stroke. J Immunol. 2012 Nov 01; 189(9):4640-7.

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Role of C3a receptors, C5a receptors, and complement protein C6 deficiency in collagen antibody-induced arthritis in mice. J Immunol. 2012 Feb 01; 188(3):1469-78.

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Identification of a central role for complement in osteoarthritis. Nat Med. 2011 Nov 06; 17(12):1674-9.

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Polyglycolic acid-induced inflammation: role of hydrolysis and resulting complement activation. Tissue Eng. 2006 Feb; 12(2):301-8.

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Molecular basis for complement component 6 (C6) deficiency in rats and mice. Immunobiology. 2004; 209(7):559-68.

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Inhibition of C5 or absence of C6 protects from sepsis mortality. Immunobiology. 2004; 209(8):629-35.

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Platelet-derived growth factor induces the beta-gamma-secretase-mediated cleavage of Alzheimer's amyloid precursor protein through a Src-Rac-dependent pathway. J Biol Chem. 2003 Mar 14; 278(11):9290-7.

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Predominant role for C5b-9 in renal ischemia/reperfusion injury. J Clin Invest. 2000 May; 105(10):1363-71.

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