Complement C9

"Complement C9" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A 63-kDa serum glycoprotein encoded by gene C9. Monomeric C9 (mC9) binds the C5b-8 complex to form C5b-9 which catalyzes the polymerization of C9 forming C5b-p9 (MEMBRANE ATTACK COMPLEX) and transmembrane channels leading to lysis of the target cell. Patients with C9 deficiency suffer from recurrent bacterial infections.

Descriptor ID

D003186

MeSH Number(s)

D12.776.124.486.274.850

Concept/Terms

Complement C9

Below are MeSH descriptors whose meaning is more general than "Complement C9".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Blood Proteins [D12.776.124]
Immunoproteins [D12.776.124.486]
Complement System Proteins [D12.776.124.486.274]
Complement C9 [D12.776.124.486.274.850]

Below are MeSH descriptors whose meaning is related to "Complement C9".

Below are MeSH descriptors whose meaning is more specific than "Complement C9".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Complement C9" by people in Harvard Catalyst Profiles by year, and whether "Complement C9" was a major or minor topic of these publication.

Bar chart showing 5 publications over 5 distinct years, with a maximum of 1 publications in 1999 and 2005 and 2009 and 2012 and 2013

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1999	1	0	1
2005	0	1	1
2009	0	1	1
2012	0	1	1
2013	1	0	1

Below are the most recent publications written about "Complement C9" by people in Profiles.

Functional assessment of mouse complement pathway activities and quantification of C3b/C3c/iC3b in an experimental model of mouse renal ischaemia/reperfusion injury. J Immunol Methods. 2015 Apr; 419:25-34.

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Rare variants in CFI, C3 and C9 are associated with high risk of advanced age-related macular degeneration. Nat Genet. 2013 Nov; 45(11):1366-70.

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Neuromodulatory state and sex specify alternative behaviors through antagonistic synaptic pathways in C. elegans. Neuron. 2012 Aug 23; 75(4):585-92.

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A novel mutation in the complement regulator clusterin in recurrent hemolytic uremic syndrome. Mol Immunol. 2009 Jul; 46(11-12):2236-43.

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Complement regulator CD59 protects against atherosclerosis by restricting the formation of complement membrane attack complex. Circ Res. 2009 Feb 27; 104(4):550-8.

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Functional studies of the MACPF domain of human complement protein C8alpha reveal sites for simultaneous binding of C8beta, C8gamma, and C9. Biochemistry. 2006 Apr 25; 45(16):5290-6.

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Epstein-Barr virus-associated bronchial leiomyoma in a boy with cellular immunodeficiency. Pediatr Pulmonol. 2006 Apr; 41(4):371-3.

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Further characterization of reproductive abnormalities in mCd59b knockout mice: a potential new function of mCd59 in male reproduction. J Immunol. 2005 Nov 15; 175(10):6294-302.

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Founder effect of the C9 R95X mutation in Orientals. Hum Genet. 2003 Mar; 112(3):244-8.

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Phylogenetic analysis of the homologous proteins of the terminal complement complex supports the emergence of C6 and C7 followed by C8 and C9. J Mol Evol. 1999 Aug; 49(2):282-9.

View in: PubMed

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