Complement C1

"Complement C1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

The first complement component to act in the activation of CLASSICAL COMPLEMENT PATHWAY. It is a calcium-dependent trimolecular complex made up of three subcomponents: COMPLEMENT C1Q; COMPLEMENT C1R; and COMPLEMENT C1S at 1:2:2 ratios. When the intact C1 binds to at least two antibodies (involving C1q), C1r and C1s are sequentially activated, leading to subsequent steps in the cascade of COMPLEMENT ACTIVATION.

Descriptor ID

D003172

MeSH Number(s)

D12.776.124.486.274.050

Concept/Terms

Complement C1

Below are MeSH descriptors whose meaning is more general than "Complement C1".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Blood Proteins [D12.776.124]
Immunoproteins [D12.776.124.486]
Complement System Proteins [D12.776.124.486.274]
Complement C1 [D12.776.124.486.274.050]

Below are MeSH descriptors whose meaning is related to "Complement C1".

Below are MeSH descriptors whose meaning is more specific than "Complement C1".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Complement C1" by people in Harvard Catalyst Profiles by year, and whether "Complement C1" was a major or minor topic of these publication.

Bar chart showing 11 publications over 9 distinct years, with a maximum of 3 publications in 2019

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1997	0	1	1
1998	0	1	1
1999	0	1	1
2003	1	0	1
2006	1	0	1
2007	0	1	1
2008	0	1	1
2012	1	0	1
2019	1	2	3

Below are the most recent publications written about "Complement C1" by people in Profiles.

In vitro evaluation of complement deposition and opsonophagocytic killing of Rhodococcus equi mediated by poly-N-acetyl glucosamine hyperimmune plasma compared to commercial plasma products. J Vet Intern Med. 2019 May; 33(3):1493-1499.

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Complement C4 Prevents Viral Infection through Capsid Inactivation. Cell Host Microbe. 2019 Apr 10; 25(4):617-629.e7.

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PNAG-specific equine IgG1 mediates significantly greater opsonization and killing of Prescottella equi (formerly Rhodococcus equi) than does IgG4/7. Vaccine. 2019 02 21; 37(9):1142-1150.

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Genetic factors for choroidal neovascularization associated with high myopia. Invest Ophthalmol Vis Sci. 2012 Jul 27; 53(8):5004-9.

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Biological activities of C1 inhibitor. Mol Immunol. 2008 Oct; 45(16):4057-63.

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Extracellular carbonic anhydrase mediates hemorrhagic retinal and cerebral vascular permeability through prekallikrein activation. Nat Med. 2007 Feb; 13(2):181-8.

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Anti-apoptotic role for C1 inhibitor in ischemia/reperfusion-induced myocardial cell injury. Biochem Biophys Res Commun. 2006 Oct 20; 349(2):504-12.

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Complement regulatory protein C1 inhibitor binds to selectins and interferes with endothelial-leukocyte adhesion. J Immunol. 2003 Nov 01; 171(9):4786-91.

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C1q and C4b bind simultaneously to CR1 and additively support erythrocyte adhesion. J Immunol. 1999 Nov 01; 163(9):5056-63.

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A small molecular weight factor in aqueous humor acts on C1q to prevent antibody-dependent complement activation. Invest Ophthalmol Vis Sci. 1998 May; 39(6):989-95.

View in: PubMed

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