Phosphoribosylaminoimidazolecarboxamide Formyltransferase
"Phosphoribosylaminoimidazolecarboxamide Formyltransferase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the conversion of aminoimidazole-4-carboxamide ribonucleotide to 5-formyl-aminoimidazole-4-carboxamide ribonucleotide in the purine de novo synthesis pathway. It requires the cofactor N(10)-FORMYLTETRAHYDROFOLATE as the formyl donor.
Concept/Terms
Phosphoribosylaminoimidazolecarboxamide Formyltransferase- Phosphoribosylaminoimidazolecarboxamide Formyltransferase
- Formyltransferase, Phosphoribosylaminoimidazolecarboxamide
- AICAR Transformylase
- Transformylase, AICAR
- Aminoimidazolecarboxamide Ribonucleotide Transformylase
- Ribonucleotide Transformylase, Aminoimidazolecarboxamide
- Transformylase, Aminoimidazolecarboxamide Ribonucleotide
- AICAR Formyltransferase
- Formyltransferase, AICAR
- AICARTFase
Below are MeSH descriptors whose meaning is more general than "Phosphoribosylaminoimidazolecarboxamide Formyltransferase".
Below are MeSH descriptors whose meaning is more specific than "Phosphoribosylaminoimidazolecarboxamide Formyltransferase".
This graph shows the total number of publications written about "Phosphoribosylaminoimidazolecarboxamide Formyltransferase" by people in Harvard Catalyst Profiles by year, and whether "Phosphoribosylaminoimidazolecarboxamide Formyltransferase" was a major or minor topic of these publication.
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Below are the most recent publications written about "Phosphoribosylaminoimidazolecarboxamide Formyltransferase" by people in Profiles.
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AICAR transformylase/IMP cyclohydrolase (ATIC) is essential for de novo purine biosynthesis and infection by Cryptococcus neoformans. J Biol Chem. 2022 10; 298(10):102453.
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Biochemical and biological studies on 2-desamino-2-methylaminopterin, an antifolate the polyglutamates of which are more potent than the monoglutamate against three key enzymes of folate metabolism. Cancer Res. 1992 Apr 15; 52(8):2148-55.
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Identification and biochemical properties of 10-formyldihydrofolate, a novel folate found in methotrexate-treated cells. J Biol Chem. 1988 May 25; 263(15):7105-11.
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Inhibition of phosphoribosylaminoimidazolecarboxamide transformylase by methotrexate and dihydrofolic acid polyglutamates. Proc Natl Acad Sci U S A. 1985 Aug; 82(15):4881-5.