Clinical Trials, Phase I as Topic
"Clinical Trials, Phase I as Topic" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Studies performed to evaluate the safety of diagnostic, therapeutic, or prophylactic drugs, devices, or techniques in healthy subjects and to determine the safe dosage range (if appropriate). These tests also are used to determine pharmacologic and pharmacokinetic properties (toxicity, metabolism, absorption, elimination, and preferred route of administration). They involve a small number of persons and usually last about 1 year. This concept includes phase I studies conducted both in the U.S. and in other countries.
MeSH Number(s)
E05.318.760.535.200
E05.337.250.200
N05.715.360.775.235.200
N06.850.520.450.535.200
Concept/Terms
Microdosing Trials, Human- Microdosing Trials, Human
- Human Microdosing Trial
- Microdosing Trial, Human
- Trial, Human Microdosing
- Trials, Human Microdosing
- Human Microdosing Trials
Below are MeSH descriptors whose meaning is more general than "Clinical Trials, Phase I as Topic".
Below are MeSH descriptors whose meaning is more specific than "Clinical Trials, Phase I as Topic".
This graph shows the total number of publications written about "Clinical Trials, Phase I as Topic" by people in Harvard Catalyst Profiles by year, and whether "Clinical Trials, Phase I as Topic" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
---|
1994 | 0 | 2 | 2 |
1995 | 1 | 2 | 3 |
1996 | 1 | 0 | 1 |
1997 | 0 | 1 | 1 |
1998 | 0 | 1 | 1 |
1999 | 2 | 3 | 5 |
2000 | 0 | 4 | 4 |
2001 | 1 | 5 | 6 |
2002 | 0 | 4 | 4 |
2003 | 0 | 3 | 3 |
2004 | 2 | 5 | 7 |
2005 | 0 | 4 | 4 |
2006 | 1 | 5 | 6 |
2007 | 1 | 7 | 8 |
2008 | 5 | 3 | 8 |
2009 | 1 | 5 | 6 |
2010 | 6 | 6 | 12 |
2011 | 1 | 6 | 7 |
2012 | 1 | 2 | 3 |
2013 | 2 | 9 | 11 |
2014 | 3 | 6 | 9 |
2015 | 1 | 9 | 10 |
2016 | 1 | 4 | 5 |
2017 | 1 | 7 | 8 |
2018 | 2 | 9 | 11 |
2019 | 1 | 13 | 14 |
2020 | 6 | 11 | 17 |
2021 | 0 | 14 | 14 |
2022 | 1 | 8 | 9 |
2023 | 0 | 2 | 2 |
2024 | 0 | 3 | 3 |
Below are the most recent publications written about "Clinical Trials, Phase I as Topic" by people in Profiles.
-
Propofol enhancement of slow wave sleep to target the nexus of geriatric depression and cognitive dysfunction: protocol for a phase I open label trial. BMJ Open. 2024 May 30; 14(5):e087516.
-
Clinical management, monitoring, and prophylaxis of adverse events of special interest associated with datopotamab deruxtecan. Cancer Treat Rev. 2024 Apr; 125:102720.
-
Consensus framework for conducting phase I/II clinical trials for children, adolescents, and young adults with pediatric low-grade glioma: Guidelines established by the International Pediatric Low-Grade Glioma Coalition Clinical Trial Working Group. Neuro Oncol. 2024 03 04; 26(3):407-416.
-
Reporting and impact of subsequent cycle toxicities in oncology phase I clinical trials. Clin Trials. 2024 04; 21(2):211-219.
-
A multicenter, phase Ib/II, open-label study of tivozanib with durvalumab in advanced hepatocellular carcinoma (DEDUCTIVE). Future Oncol. 2022 Dec; 18(40):4465-4471.
-
Immune checkpoint blockers in patients with unresectable or metastatic thymic epithelial tumours: A meta-analysis. Eur J Cancer. 2023 02; 180:117-124.
-
Identifying Body Awareness-Related Brain Network Changes After Cognitive Multisensory Rehabilitation for Neuropathic Pain Relief in Adults With Spinal Cord Injury: Protocol of a Phase I Randomized Controlled Trial. Top Spinal Cord Inj Rehabil. 2022; 28(4):33-43.
-
Study protocol for a phase II, double-blind, randomised controlled trial of cannabidiol (CBD) compared with placebo for reduction of brain neuroinflammation in adults with chronic low back pain. BMJ Open. 2022 09 19; 12(9):e063613.
-
Protocol for a randomized controlled trial of mindfulness-based stress reduction to improve attentional control in older adults (HealthyAgers trial). BMC Geriatr. 2022 08 13; 22(1):666.
-
Efficacy and safety of larotrectinib in patients with TRK fusion-positive thyroid carcinoma. Eur J Endocrinol. 2022 Apr 29; 186(6):631-643.