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Gene Amplification

"Gene Amplification" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

A selective increase in the number of copies of a gene coding for a specific protein without a proportional increase in other genes. It occurs naturally via the excision of a copy of the repeating sequence from the chromosome and its extrachromosomal replication in a plasmid, or via the production of an RNA transcript of the entire repeating sequence of ribosomal RNA followed by the reverse transcription of the molecule to produce an additional copy of the original DNA sequence. Laboratory techniques have been introduced for inducing disproportional replication by unequal crossing over, uptake of DNA from lysed cells, or generation of extrachromosomal sequences from rolling circle replication.


This graph shows the total number of publications written about "Gene Amplification" by people in Harvard Catalyst Profiles by year, and whether "Gene Amplification" was a major or minor topic of these publication.
Bar chart showing 510 publications over 30 distinct years, with a maximum of 34 publications in 2013 and 2014
To see the data from this visualization as text, click here.