E2F4 Transcription Factor

"E2F4 Transcription Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

An E2F transcription factor that represses GENETIC TRANSCRIPTION required for CELL CYCLE entry and DNA synthesis. E2F4 recruits chromatin remodeling factors indirectly to target gene PROMOTER REGIONS through RETINOBLASTOMA LIKE PROTEIN P130 and RETINOBLASTOMA LIKE PROTEIN P107.

Descriptor ID

D050704

MeSH Number(s)

D12.776.930.311.812

Concept/Terms

E2F4 Transcription Factor

Below are MeSH descriptors whose meaning is more general than "E2F4 Transcription Factor".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Transcription Factors [D12.776.930]
E2F Transcription Factors [D12.776.930.311]
E2F4 Transcription Factor [D12.776.930.311.812]

Below are MeSH descriptors whose meaning is related to "E2F4 Transcription Factor".

Below are MeSH descriptors whose meaning is more specific than "E2F4 Transcription Factor".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "E2F4 Transcription Factor" by people in Harvard Catalyst Profiles by year, and whether "E2F4 Transcription Factor" was a major or minor topic of these publication.

Bar chart showing 27 publications over 17 distinct years, with a maximum of 4 publications in 2000

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1994	0	1	1
1995	0	2	2
1996	0	2	2
1999	0	1	1
2000	0	4	4
2001	0	3	3
2005	0	1	1
2006	1	0	1
2007	2	0	2
2008	1	1	2
2009	1	0	1
2010	1	0	1
2011	0	1	1
2012	1	0	1
2014	1	1	2
2016	1	0	1
2017	1	0	1

Below are the most recent publications written about "E2F4 Transcription Factor" by people in Profiles.

Cytoplasmic E2f4 forms organizing centres for initiation of centriole amplification during multiciliogenesis. Nat Commun. 2017 07 04; 8:15857.

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Integrative Genomic Analyses Yield Cell-Cycle Regulatory Programs with Prognostic Value. Mol Cancer Res. 2016 Apr; 14(4):332-43.

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E2F4 regulatory program predicts patient survival prognosis in breast cancer. Breast Cancer Res. 2014 Dec 02; 16(6):486.

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The DREAM complex in antitumor activity of imatinib mesylate in gastrointestinal stromal tumors. Curr Opin Oncol. 2014 Jul; 26(4):415-21.

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Coordinated repression of cell cycle genes by KDM5A and E2F4 during differentiation. Proc Natl Acad Sci U S A. 2012 Nov 06; 109(45):18499-504.

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Peroxisome proliferator-activated receptor ß/d cross talks with E2F and attenuates mitosis in HRAS-expressing cells. Mol Cell Biol. 2012 Jun; 32(11):2065-82.

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DYRK1A protein kinase promotes quiescence and senescence through DREAM complex assembly. Genes Dev. 2011 Apr 15; 25(8):801-13.

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Disruption of calvarial ossification in E2f4 mutant embryos correlates with increased proliferation and progenitor cell populations. Cell Cycle. 2010 Jul 01; 9(13):2620-8.

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ARF stimulates XPC to trigger nucleotide excision repair by regulating the repressor complex of E2F4. EMBO Rep. 2009 Sep; 10(9):1036-42.

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E2F4 cooperates with pRB in the development of extra-embryonic tissues. Dev Biol. 2009 Aug 01; 332(1):104-15.

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