E2F Transcription Factors

"E2F Transcription Factors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A family of basic helix-loop-helix transcription factors that control expression of a variety of GENES involved in CELL CYCLE regulation. E2F transcription factors typically form heterodimeric complexes with TRANSCRIPTION FACTOR DP1 or transcription factor DP2, and they have N-terminal DNA binding and dimerization domains. E2F transcription factors can act as mediators of transcriptional repression or transcriptional activation.

Descriptor ID

D050684

MeSH Number(s)

D12.776.930.311

Concept/Terms

E2F Transcription Factors

Below are MeSH descriptors whose meaning is more general than "E2F Transcription Factors".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Transcription Factors [D12.776.930]
E2F Transcription Factors [D12.776.930.311]

Below are MeSH descriptors whose meaning is related to "E2F Transcription Factors".

Below are MeSH descriptors whose meaning is more specific than "E2F Transcription Factors".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "E2F Transcription Factors" by people in Harvard Catalyst Profiles by year, and whether "E2F Transcription Factors" was a major or minor topic of these publication.

Bar chart showing 171 publications over 30 distinct years, with a maximum of 16 publications in 1996

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1994	0	10	10
1995	0	15	15
1996	0	16	16
1997	0	8	8
1998	0	6	6
1999	0	9	9
2000	0	15	15
2001	0	13	13
2002	0	12	12
2003	0	9	9
2004	1	4	5
2005	0	3	3
2006	3	2	5
2007	1	1	2
2008	2	0	2
2009	1	2	3
2010	0	2	2
2011	2	2	4
2012	3	2	5
2013	1	1	2
2014	1	2	3
2015	2	1	3
2016	0	2	2
2017	2	2	4
2018	1	3	4
2019	0	2	2
2020	1	0	1
2021	1	2	3
2022	0	1	1
2023	0	2	2

Below are the most recent publications written about "E2F Transcription Factors" by people in Profiles.

Patterns in the tapestry of chromatin-bound RB. Trends Cell Biol. 2024 Apr; 34(4):288-298.

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Seeing is believing: the impact of RB on nuclear organization. Cell Cycle. 2023 06; 22(11):1357-1366.

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Chromatin-bound RB targets promoters, enhancers, and CTCF-bound loci and is redistributed by cell-cycle progression. Mol Cell. 2022 09 15; 82(18):3333-3349.e9.

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Cyclin-Dependent Kinase 4/6 Inhibitors: Is a Noncanonical Substrate the Key Target? Cancer Res. 2022 04 01; 82(7):1170-1171.

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RB depletion is required for the continuous growth of tumors initiated by loss of RB. PLoS Genet. 2021 12; 17(12):e1009941.

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Simultaneous expression of MMB-FOXM1 complex components enables efficient bypass of senescence. Sci Rep. 2021 11 02; 11(1):21506.

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E2F/Dp inactivation in fat body cells triggers systemic metabolic changes. Elife. 2021 07 12; 10.

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The oncofetal RNA-binding protein IGF2BP1 is a druggable, post-transcriptional super-enhancer of E2F-driven gene expression in cancer. Nucleic Acids Res. 2020 09 04; 48(15):8576-8590.

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Tumor Milieu Controlled by RB Tumor Suppressor. Int J Mol Sci. 2020 Apr 01; 21(7).

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Chromatin accessibility and transcription dynamics during in vitro astrocyte differentiation of Huntington's Disease Monkey pluripotent stem cells. Epigenetics Chromatin. 2019 11 13; 12(1):67.

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