Deoxyribonucleases, Type II Site-Specific
"Deoxyribonucleases, Type II Site-Specific" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Enzyme systems containing a single subunit and requiring only magnesium for endonucleolytic activity. The corresponding modification methylases are separate enzymes. The systems recognize specific short DNA sequences and cleave either within, or at a short specific distance from, the recognition sequence to give specific double-stranded fragments with terminal 5'-phosphates. Enzymes from different microorganisms with the same specificity are called isoschizomers. EC 3.1.21.4.
MeSH Number(s)
D08.811.150.280.260
D08.811.277.352.335.350.300.260
D08.811.277.352.355.325.300.260
Concept/Terms
Deoxyribonucleases, Type II Site-Specific- Deoxyribonucleases, Type II Site-Specific
- Deoxyribonucleases, Type II Site Specific
- Deoxyribonucleases, Type II, Site-Specific
- Type II Site Specific Deoxyribonucleases
- Type II Site-Specific Deoxyribonucleases
- DNA Restriction Enzymes, Type II
- Type II Restriction Enzymes
- Site-Specific DNase, Type II
- Site Specific DNase, Type II
- Type II Site Specific DNase
- Type II Site-Specific DNase
- DNase, Site-Specific, Type II
- Restriction Endonucleases, Type II
- Deoxyribonucleases, Type II, Site Specific
- DNase, Site Specific, Type II
Below are MeSH descriptors whose meaning is more general than "Deoxyribonucleases, Type II Site-Specific".
Below are MeSH descriptors whose meaning is more specific than "Deoxyribonucleases, Type II Site-Specific".
This graph shows the total number of publications written about "Deoxyribonucleases, Type II Site-Specific" by people in Harvard Catalyst Profiles by year, and whether "Deoxyribonucleases, Type II Site-Specific" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 2 | 5 | 7 |
| 1995 | 0 | 1 | 1 |
| 1996 | 0 | 4 | 4 |
| 1997 | 2 | 2 | 4 |
| 1998 | 0 | 1 | 1 |
| 1999 | 4 | 2 | 6 |
| 2000 | 2 | 3 | 5 |
| 2001 | 1 | 4 | 5 |
| 2002 | 1 | 0 | 1 |
| 2003 | 1 | 1 | 2 |
| 2004 | 1 | 4 | 5 |
| 2005 | 0 | 3 | 3 |
| 2006 | 2 | 2 | 4 |
| 2007 | 1 | 0 | 1 |
| 2008 | 1 | 1 | 2 |
| 2010 | 1 | 0 | 1 |
| 2011 | 3 | 2 | 5 |
| 2012 | 4 | 2 | 6 |
| 2014 | 1 | 2 | 3 |
| 2015 | 1 | 1 | 2 |
| 2017 | 1 | 1 | 2 |
| 2021 | 0 | 2 | 2 |
Below are the most recent publications written about "Deoxyribonucleases, Type II Site-Specific" by people in Profiles.
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Defining genome-wide CRISPR-Cas genome-editing nuclease activity with GUIDE-seq. Nat Protoc. 2021 Dec; 16(12):5592-5615.
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Single-Molecule Dwell-Time Analysis of Restriction Endonuclease-Mediated DNA Cleavage. J Vis Exp. 2021 02 07; (168).
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ATP-powered molecular recognition to engineer transient multivalency and self-sorting 4D hierarchical systems. Nat Commun. 2020 07 21; 11(1):3658.
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Crystal Structure and Directed Evolution of Specificity of NlaIV Restriction Endonuclease. J Mol Biol. 2019 05 17; 431(11):2082-2094.
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FANCJ helicase controls the balance between short- and long-tract gene conversions between sister chromatids. Nucleic Acids Res. 2017 Sep 06; 45(15):8886-8900.
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BET-Bromodomain Inhibitors Engage the Host Immune System and Regulate Expression of the Immune Checkpoint Ligand PD-L1. Cell Rep. 2017 02 28; 18(9):2162-2174.
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Genetic Polymorphisms in the ESR1 and VDR Genes Do Not Correlate With Osteoporosis in Patients With Familial Dysautonomia. J Clin Densitom. 2018 Apr - Jun; 21(2):205-212.
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A single molecule assay for measuring site-specific DNA cleavage. Anal Biochem. 2016 Feb 15; 495:3-5.
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Identification of a Recognizable Progressive Skeletal Dysplasia Caused by RSPRY1 Mutations. Am J Hum Genet. 2015 Oct 01; 97(4):608-15.
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Efficient fdCas9 Synthetic Endonuclease with Improved Specificity for Precise Genome Engineering. PLoS One. 2015; 10(7):e0133373.