Interleukin-21 Receptor alpha Subunit

"Interleukin-21 Receptor alpha Subunit" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

An interleukin-21 receptor subunit that combines with the INTERLEUKIN RECEPTOR COMMON GAMMA SUBUNIT to form a high affinity receptor for interleukin-21. It signals via interaction of its cytoplasmic domain with JANUS KINASES such as JANUS KINASE 1 and JANUS KINASE 3.

Descriptor ID

D053738

MeSH Number(s)

D12.776.543.750.705.852.420.900.450

Concept/Terms

Interleukin-21 Receptor alpha Subunit

Below are MeSH descriptors whose meaning is more general than "Interleukin-21 Receptor alpha Subunit".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Membrane Proteins [D12.776.543]
Receptors, Cell Surface [D12.776.543.750]
Receptors, Immunologic [D12.776.543.750.705]
Receptors, Cytokine [D12.776.543.750.705.852]
Receptors, Interleukin [D12.776.543.750.705.852.420]
Receptors, Interleukin-21 [D12.776.543.750.705.852.420.900]
Interleukin-21 Receptor alpha Subunit [D12.776.543.750.705.852.420.900.450]

Below are MeSH descriptors whose meaning is related to "Interleukin-21 Receptor alpha Subunit".

Below are MeSH descriptors whose meaning is more specific than "Interleukin-21 Receptor alpha Subunit".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Interleukin-21 Receptor alpha Subunit" by people in Harvard Catalyst Profiles by year, and whether "Interleukin-21 Receptor alpha Subunit" was a major or minor topic of these publication.

Bar chart showing 11 publications over 10 distinct years, with a maximum of 2 publications in 2011

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2002	0	1	1
2003	0	1	1
2004	0	1	1
2006	0	1	1
2011	0	2	2
2013	1	0	1
2014	0	1	1
2015	1	0	1
2016	0	1	1
2021	0	1	1

Below are the most recent publications written about "Interleukin-21 Receptor alpha Subunit" by people in Profiles.

Targeting Cbx3/HP1? Induces LEF-1 and IL-21R to Promote Tumor-Infiltrating CD8 T-Cell Persistence. Front Immunol. 2021; 12:738958.

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Alternative Splicing Rescues Loss of Common Gamma Chain Function and Results in IL-21R-like Deficiency. J Clin Immunol. 2019 02; 39(2):207-215.

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Interleukin-22 promotes phagolysosomal fusion to induce protection against Salmonella enterica Typhimurium in human epithelial cells. Proc Natl Acad Sci U S A. 2018 10 02; 115(40):10118-10123.

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Suppression by TFR cells leads to durable and selective inhibition of B cell effector function. Nat Immunol. 2016 Dec; 17(12):1436-1446.

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IL-21R signaling is critical for induction of spontaneous experimental autoimmune encephalomyelitis. J Clin Invest. 2015 Nov 02; 125(11):4011-20.

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The elevated expression of Th17-related cytokines and receptors is associated with skin lesion severity in early systemic sclerosis. Hum Immunol. 2015 Jan; 76(1):22-9.

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Potential role of myeloid cell/eosinophil-derived IL-17 in LPS-induced endotoxin shock. Biochem Biophys Res Commun. 2014 Oct 10; 453(1):1-6.

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Loss-of-function mutations in the IL-21 receptor gene cause a primary immunodeficiency syndrome. J Exp Med. 2013 Mar 11; 210(3):433-43.

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Differential IL-21 signaling in APCs leads to disparate Th17 differentiation in diabetes-susceptible NOD and diabetes-resistant NOD.Idd3 mice. J Clin Invest. 2011 Nov; 121(11):4303-10.

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Abrogation of donor T-cell IL-21 signaling leads to tissue-specific modulation of immunity and separation of GVHD from GVL. Blood. 2011 Jul 14; 118(2):446-55.

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