"Connexin 43" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A 43-kDa peptide which is a member of the connexin family of gap junction proteins. Connexin 43 is a product of a gene in the alpha class of connexin genes (the alpha-1 gene). It was first isolated from mammalian heart, but is widespread in the body including the brain.
Below are MeSH descriptors whose meaning is more general than "Connexin 43".
Below are MeSH descriptors whose meaning is more specific than "Connexin 43".
This graph shows the total number of publications written about "Connexin 43" by people in Harvard Catalyst Profiles by year, and whether "Connexin 43" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 1 | 2 | 3 |
| 1995 | 1 | 3 | 4 |
| 1996 | 1 | 3 | 4 |
| 1997 | 1 | 0 | 1 |
| 1998 | 5 | 2 | 7 |
| 1999 | 1 | 3 | 4 |
| 2000 | 3 | 2 | 5 |
| 2001 | 7 | 3 | 10 |
| 2002 | 3 | 2 | 5 |
| 2003 | 5 | 6 | 11 |
| 2004 | 5 | 2 | 7 |
| 2005 | 4 | 1 | 5 |
| 2006 | 4 | 3 | 7 |
| 2007 | 3 | 2 | 5 |
| 2008 | 3 | 1 | 4 |
| 2009 | 1 | 3 | 4 |
| 2010 | 2 | 0 | 2 |
| 2011 | 5 | 5 | 10 |
| 2012 | 6 | 1 | 7 |
| 2013 | 1 | 2 | 3 |
| 2014 | 3 | 0 | 3 |
| 2015 | 4 | 3 | 7 |
| 2016 | 5 | 8 | 13 |
| 2017 | 1 | 4 | 5 |
| 2018 | 1 | 3 | 4 |
| 2019 | 2 | 1 | 3 |
| 2020 | 1 | 2 | 3 |
| 2021 | 1 | 0 | 1 |
| 2022 | 1 | 1 | 2 |
| 2023 | 1 | 0 | 1 |
| 2024 | 1 | 0 | 1 |
Below are the most recent publications written about "Connexin 43" by people in Profiles.
-
Casein Kinase 1 Phosphomimetic Mutations Negatively Impact Connexin-43 Gap Junctions in Human Pluripotent Stem Cell-Derived Cardiomyocytes. Biomolecules. 2024 Jan 02; 14(1).
-
GJA1-20k Rescues Cx43 Localization and Arrhythmias in Arrhythmogenic Cardiomyopathy. Circ Res. 2023 03 17; 132(6):744-746.
-
CX3CR1 deficiency leads to impairment of immune surveillance in the epididymis. Cell Mol Life Sci. 2022 Dec 23; 80(1):15.
-
The MAPK/ERK signaling pathway regulates the expression and localization of Cx43 in mouse proximal epididymis†. Biol Reprod. 2022 05 17; 106(5):919-927.
-
TICAM-1/TRIF associates with Act1 and suppresses IL-17 receptor-mediated inflammatory responses. Life Sci Alliance. 2022 02; 5(2).
-
Intercellular Transmission of Hepatic ER Stress in Obesity Disrupts Systemic Metabolism. Cell Metab. 2021 02 02; 33(2):319-333.e6.
-
Connexin Hemichannel Mimetic Peptide Attenuates Cortical Interneuron Loss and Perineuronal Net Disruption Following Cerebral Ischemia in Near-Term Fetal Sheep. Int J Mol Sci. 2020 Sep 04; 21(18).
-
Auxiliary trafficking subunit GJA1-20k protects connexin-43 from degradation and limits ventricular arrhythmias. J Clin Invest. 2020 09 01; 130(9):4858-4870.
-
Staphylococcus aureus impairs cutaneous wound healing by activating the expression of a gap junction protein, connexin-43 in keratinocytes. Cell Mol Life Sci. 2021 Feb; 78(3):935-947.
-
A role for connexin-43 in Duchenne muscular dystrophy cardiomyopathy. J Clin Invest. 2020 04 01; 130(4):1608-1610.