Harvard Catalyst Profiles

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Jeffrey E Saffitz, M.D., Ph.D.

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Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R01HL148348 (SAFFITZ, JEFFREY E) Apr 1, 2020 - Mar 31, 2025
    NIH
    Arrhythmogenic Cardiomyopathy is an Inflammatory Disease
    Role: Principal Investigator
  2. R01HL136463 (SAFFITZ, JEFFREY E) Jul 15, 2018 - Jun 30, 2022
    NIH
    Altered Cell-Cell Coupling in Arrhythmogenic Cardiomyopathy
    Role: Principal Investigator
  3. R01HL116906 (TOWBIN, JEFFREY ALLEN) Aug 23, 2013 - Jun 30, 2019
    NIH
    Genetics, Mechanisms and Clinical Phenotypes of Arrhythmogenic Cardiomyopathy
    Role: Co-Principal Investigator
  4. R01HL102361 (SAFFITZ, JEFFREY E) Apr 1, 2010 - Sep 30, 2014
    NIH
    Disease Mechanisms in ARVC
    Role: Principal Investigator
  5. RC1HL100110 (SAFFITZ, JEFFREY E) Sep 30, 2009 - Aug 31, 2012
    NIH
    Determinants of Disease Expression in Arrhythmogenic Cardiomyopathy
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
Displaying 25 of 318 total Publications Show all
  1. Protonotarios A, Asimaki A, Basso C, Xylouri Z, Monda E, Protonotarios I, Crisci G, Abrahms DJ, Anastasakis A, Antoniades L, Bakalakos A, Carbone A, S Coonar A, Gimeno JR, Lazaros G, Lerakis S, Mestroni L, Papadopoulos G, Pecchia L, Prandi FR, Syrris P, Cadrin-Turigny J, Vasilakis A, Saffitz JE, Gaetano Thiene S, Elliott PM, Kaski JP, McKenna WJ, Bossone E, Limongelli G, Tsatsopoulou A. Naxos Disease and Related Cardio-Cutaneous Syndromes. JACC Adv. 2025 Feb; 4(2):101547. PMID: 39877668; PMCID: PMC11773020.
    Citations:
  2. Penna VR, Amrute JM, Engel M, Shiel EA, Farra W, Cannon EN, Leu-Turner C, Ma P, Villanueva A, Shin H, Parvathaneni A, Jager J, Bueno-Beti C, Asimaki A, Lavine KJ, Saffitz JE, Chelko SP. Interleukin-1ß Drives Disease Progression in Arrhythmogenic Cardiomyopathy. bioRxiv. 2024 Dec 17. PMID: 39763850; PMCID: PMC11702578.
    Citations:
  3. Chelko SP, Penna VR, Engel M, Shiel EA, Centner AM, Farra W, Cannon EN, Landim-Vieira M, Schaible N, Lavine K, Saffitz JE. NF?B signaling drives myocardial injury via CCR2+ macrophages in a preclinical model of arrhythmogenic cardiomyopathy. J Clin Invest. 2024 Jul 01; 134(13). PMID: 38949031; PMCID: PMC11213461.
    Citations:
    Fields: MedMedicine (General)Translation:HumansAnimalsCells
  4. Chelko SP, Penna VR, Engel M, Shiel EA, Centner AM, Farra W, Cannon EN, Landim-Vieira M, Schaible N, Lavine K, Saffitz JE. NF?B signaling drives myocardial injury via CCR2+ macrophages in a preclinical model of arrhythmogenic cardiomyopathy. J Clin Invest. 2024 Apr 02; 134(10). PMID: 38564300; PMCID: PMC11093597.
    Citations: 7
    Fields: MedMedicine (General)Translation:HumansAnimalsCells
  5. Panigrahy D, Kelly AG, Wang W, Yang J, Hwang SH, Gillespie M, Howard I, Bueno-Beti C, Asimaki A, Penna V, Lavine K, Edin ML, Zeldin DC, Hammock BD, Saffitz JE. Inhibition of Soluble Epoxide Hydrolase Reduces Inflammation and Myocardial Injury in Arrhythmogenic Cardiomyopathy. bioRxiv. 2024 Feb 19. PMID: 38463975; PMCID: PMC10925075.
    Citations:
  6. Namasivayam M, Bertrand PB, Bernard S, Churchill TW, Khurshid S, Marcus FI, Mestroni L, Saffitz JE, Towbin JA, Zareba W, Picard MH, Sanborn DY, North American ARVC Registry. Utility of Left and Right Ventricular Strain in Arrhythmogenic Right Ventricular Cardiomyopathy: A Prospective Multicenter Registry. Circ Cardiovasc Imaging. 2023 12; 16(12):e015671. PMID: 38113321; PMCID: PMC10803132.
    Citations: 2
    Fields: CarCardiologyDiaDiagnostic ImagingVasVascular DiseasesTranslation:Humans
  7. Jin Q, Lee KY, Selimi Z, Shimura D, Wang E, Zimmerman JF, Shaw RM, Kucera JP, Parker KK, Saffitz JE, Kleber AG. Determinants of electrical propagation and propagation block in Arrhythmogenic Cardiomyopathy. J Mol Cell Cardiol. 2024 01; 186:71-80. PMID: 37956903; PMCID: PMC10872523.
    Citations: 1
    Fields: CarCardiologyCelCell BiologyMolMolecular BiologyTranslation:AnimalsCells
  8. Bueno-Beti C, Tafuni A, Chelko SP, Sheppard MN, Field E, Tollit J, Heenan IK, Barnes A, Taylor MR, Mestroni L, Kaski JP, Saffitz JE, Asimaki A. Innate immune signaling in hearts and buccal mucosa cells of patients with arrhythmogenic cardiomyopathy. Heart Rhythm O2. 2023 Oct; 4(10):650-659. PMID: 37936669; PMCID: PMC10626188.
    Citations: 3
  9. Bueto-Beni C, Tafuni A, Chelko SP, Sheppard MN, Field E, Tollit J, Heenan IK, Barnes A, Taylor MR, Mestroni L, Kaski JP, Saffitz JE, Asimaki A. Innate Immune Signaling in Hearts and Buccal Mucosa Cells of Patients with Arrhythmogenic Cardiomyopathy. bioRxiv. 2023 Jul 27. PMID: 37649905; PMCID: PMC10465021.
    Citations:
  10. Chelko SP, Penna V, Engel M, Landim-Vieira M, Cannon EN, Lavine K, Saffitz JE. Mechanisms of Innate Immune Injury in Arrhythmogenic Cardiomyopathy. bioRxiv. 2023 Jul 13. PMID: 37503283; PMCID: PMC10370013.
    Citations:
  11. Palatinus JA, Valdez S, Taylor L, Whisenant C, Selzman CH, Drakos SG, Ranjan R, Hong T, Saffitz JE, Shaw RM. GJA1-20k Rescues Cx43 Localization and Arrhythmias in Arrhythmogenic Cardiomyopathy. Circ Res. 2023 03 17; 132(6):744-746. PMID: 36927183; PMCID: PMC10314823.
    Citations: 10
    Fields: CarCardiologyVasVascular DiseasesTranslation:HumansCells
  12. Thiene G, Buja G, Bauce B, Corrado D, Basso C, Saffitz J. Obituary for Frank Marcus, outstanding medical scientist of right ventricular dysplasia/cardiomyopathy. Eur Heart J. 2023 Feb 18. PMID: 36807418.
    Citations:
    Fields: CarCardiology
  13. Bueno-Beti C, Field E, Tsatsopoulou A, Perry G, Sheppard MN, Behr ER, Saffitz JE, Kaski JP, Asimaki A. Analysis of buccal mucosa as a prognostic tool in children with arrhythmogenic cardiomyopathy. Prog Pediatr Cardiol. 2022 Mar; 64:None. PMID: 35300203; PMCID: PMC8917042.
    Citations: 2
  14. Hawthorne RN, Blazeski A, Lowenthal J, Kannan S, Teuben R, DiSilvestre D, Morrissette-McAlmon J, Saffitz JE, Boheler KR, James CA, Chelko SP, Tomaselli G, Tung L. Altered Electrical, Biomolecular, and Immunologic Phenotypes in a Novel Patient-Derived Stem Cell Model of Desmoglein-2 Mutant ARVC. J Clin Med. 2021 Jul 10; 10(14). PMID: 34300226.
    Citations: 17
  15. Chelko SP, Saffitz JE. Role of galectin-3 in the pathogenesis of arrhythmogenic cardiomyopathy-It's complicated. Heart Rhythm. 2021 08; 18(8):1404-1405. PMID: 33905812.
    Citations:
    Fields: CarCardiologyTranslation:Humans
  16. Chelko SP, Keceli G, Carpi A, Doti N, Agrimi J, Asimaki A, Beti CB, Miyamoto M, Amat-Codina N, Bedja D, Wei AC, Murray B, Tichnell C, Kwon C, Calkins H, James CA, O'Rourke B, Halushka MK, Melloni E, Saffitz JE, Judge DP, Ruvo M, Kitsis RN, Andersen P, Di Lisa F, Paolocci N. Exercise triggers CAPN1-mediated AIF truncation, inducing myocyte cell death in arrhythmogenic cardiomyopathy. Sci Transl Med. 2021 02 17; 13(581). PMID: 33597260; PMCID: PMC8936193.
    Citations: 36
    Fields: MedMedicine (General)SciScienceTranslation:AnimalsCells
  17. Corradi D, Saffitz JE, Novelli D, Asimaki A, Simon C, Oldoni E, Masson S, Meessen JMTA, Monaco R, Manuguerra R, Latini R, Libby P, Tavazzi L, Marchioli R, Dozza L, Cavallotti L, Aleksova A, Gregorini R, Mozaffarian D. Prospective Evaluation of Clinico-Pathological Predictors of Postoperative Atrial Fibrillation: An Ancillary Study From the OPERA Trial. Circ Arrhythm Electrophysiol. 2020 08; 13(8):e008382. PMID: 32654517; PMCID: PMC7457312.
    Citations: 4
    Fields: CarCardiologyVasVascular DiseasesTranslation:Humans
  18. Lerchenmüller C, Rabolli CP, Yeri A, Kitchen R, Salvador AM, Liu LX, Ziegler O, Danielson K, Platt C, Shah R, Damilano F, Kundu P, Riechert E, Katus HA, Saffitz JE, Keshishian H, Carr SA, Bezzerides VJ, Das S, Rosenzweig A. CITED4 Protects Against Adverse Remodeling in Response to Physiological and Pathological Stress. Circ Res. 2020 08 14; 127(5):631-646. PMID: 32418505; PMCID: PMC7725361.
    Citations: 30
    Fields: CarCardiologyVasVascular DiseasesTranslation:AnimalsCells
  19. Shaw RM, Saffitz JE. A role for connexin-43 in Duchenne muscular dystrophy cardiomyopathy. J Clin Invest. 2020 04 01; 130(4):1608-1610. PMID: 32091412; PMCID: PMC7108900.
    Citations: 3
    Fields: MedMedicine (General)Translation:HumansAnimalsCells
  20. Camors EM, Purevjav E, Jefferies JL, Saffitz JE, Gong N, Ryan TD, Lucky AW, Taylor MD, Sullivan LM, Mestroni L, Towbin JA. Early Lethality Due to a Novel Desmoplakin Variant Causing Infantile Epidermolysis Bullosa Simplex With Fragile Skin, Aplasia Cutis Congenita, and Arrhythmogenic Cardiomyopathy. Circ Genom Precis Med. 2020 04; 13(2):e002800. PMID: 32164419; PMCID: PMC7176531.
    Citations: 7
    Fields: CarCardiologyGenGenetics, MedicalVasVascular DiseasesTranslation:Humans
  21. Towbin JA, McKenna WJ, Abrams DJ, Ackerman MJ, Calkins H, Darrieux FCC, Daubert JP, de Chillou C, DePasquale EC, Desai MY, Estes NAM, Hua W, Indik JH, Ingles J, James CA, John RM, Judge DP, Keegan R, Krahn AD, Link MS, Marcus FI, McLeod CJ, Mestroni L, Priori SG, Saffitz JE, Sanatani S, Shimizu W, van Tintelen JP, Wilde AAM, Zareba W. 2019 HRS expert consensus statement on evaluation, risk stratification, and management of arrhythmogenic cardiomyopathy: Executive summary. Heart Rhythm. 2019 11; 16(11):e373-e407. PMID: 31676023.
    Citations: 62
    Fields: CarCardiologyTranslation:Humans
  22. Chelko SP, Asimaki A, Lowenthal J, Bueno-Beti C, Bedja D, Scalco A, Amat-Alarcon N, Andersen P, Judge DP, Tung L, Saffitz JE. Therapeutic Modulation of the Immune Response in Arrhythmogenic Cardiomyopathy. Circulation. 2019 10 29; 140(18):1491-1505. PMID: 31533459; PMCID: PMC6817418.
    Citations: 88
    Fields: CarCardiologyVasVascular DiseasesTranslation:AnimalsCells
  23. Austin KM, Trembley MA, Chandler SF, Sanders SP, Saffitz JE, Abrams DJ, Pu WT. Molecular mechanisms of arrhythmogenic cardiomyopathy. Nat Rev Cardiol. 2019 09; 16(9):519-537. PMID: 31028357; PMCID: PMC6871180.
    Citations: 117
    Fields: CarCardiologyTranslation:HumansAnimalsCells
  24. Barkagan M, Leshem E, Shapira-Daniels A, Sroubek J, Buxton AE, Saffitz JE, Anter E. Histopathological Characterization of Radiofrequency Ablation in Ventricular Scar Tissue. JACC Clin Electrophysiol. 2019 08; 5(8):920-931. PMID: 31439293.
    Citations: 23
    Fields: CarCardiologyTranslation:Animals
  25. Towbin JA, McKenna WJ, Abrams DJ, Ackerman MJ, Calkins H, Darrieux FCC, Daubert JP, de Chillou C, DePasquale EC, Desai MY, Estes NAM, Hua W, Indik JH, Ingles J, James CA, John RM, Judge DP, Keegan R, Krahn AD, Link MS, Marcus FI, McLeod CJ, Mestroni L, Priori SG, Saffitz JE, Sanatani S, Shimizu W, van Tintelen JP, Wilde AAM, Zareba W. 2019 HRS expert consensus statement on evaluation, risk stratification, and management of arrhythmogenic cardiomyopathy. Heart Rhythm. 2019 11; 16(11):e301-e372. PMID: 31078652.
    Citations: 276
    Fields: CarCardiologyTranslation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.