Complement Pathway, Classical
"Complement Pathway, Classical" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Complement activation initiated by the binding of COMPLEMENT C1 to ANTIGEN-ANTIBODY COMPLEXES at the COMPLEMENT C1Q subunit. This leads to the sequential activation of COMPLEMENT C1R and COMPLEMENT C1S subunits. Activated C1s cleaves COMPLEMENT C4 and COMPLEMENT C2 forming the membrane-bound classical C3 CONVERTASE (C4B2A) and the subsequent C5 CONVERTASE (C4B2A3B) leading to cleavage of COMPLEMENT C5 and the assembly of COMPLEMENT MEMBRANE ATTACK COMPLEX.
Concept/Terms
Complement Pathway, Classical- Complement Pathway, Classical
- Classical Complement Activation Pathway
- Complement Activation Pathway, Classical
- Classical Complement Pathway
Below are MeSH descriptors whose meaning is more general than "Complement Pathway, Classical".
Below are MeSH descriptors whose meaning is more specific than "Complement Pathway, Classical".
This graph shows the total number of publications written about "Complement Pathway, Classical" by people in Harvard Catalyst Profiles by year, and whether "Complement Pathway, Classical" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 2 | 3 |
| 1997 | 0 | 2 | 2 |
| 1998 | 2 | 1 | 3 |
| 1999 | 1 | 1 | 2 |
| 2000 | 2 | 2 | 4 |
| 2001 | 1 | 1 | 2 |
| 2002 | 0 | 2 | 2 |
| 2005 | 0 | 4 | 4 |
| 2006 | 2 | 2 | 4 |
| 2009 | 0 | 1 | 1 |
| 2010 | 1 | 0 | 1 |
| 2011 | 2 | 1 | 3 |
| 2012 | 0 | 2 | 2 |
| 2014 | 2 | 1 | 3 |
| 2015 | 1 | 0 | 1 |
| 2016 | 0 | 3 | 3 |
| 2017 | 1 | 0 | 1 |
| 2023 | 0 | 1 | 1 |
Below are the most recent publications written about "Complement Pathway, Classical" by people in Profiles.
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Safety and efficacy of classical complement pathway inhibition with sutimlimab in chronic immune thrombocytopenia. Blood Adv. 2023 03 28; 7(6):987-996.
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Targeting the Complement Alternative Pathway Permits Graft Versus Leukemia Activity while Preventing Graft Versus Host Disease. Clin Cancer Res. 2020 07 01; 26(13):3481-3490.
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Potential of Murine IgG1 and Human IgG4 to Inhibit the Classical Complement and Fc? Receptor Activation Pathways. Front Immunol. 2018; 9:958.
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Species Specificity of Vaccinia Virus Complement Control Protein for the Bovine Classical Pathway Is Governed Primarily by Direct Interaction of Its Acidic Residues with Factor I. J Virol. 2017 10 01; 91(19).
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Anti-C1q in systemic lupus erythematosus. Lupus. 2016 Jul; 25(8):873-7.
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A complement-microglial axis drives synapse loss during virus-induced memory impairment. Nature. 2016 06 23; 534(7608):538-43.
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Polyphosphate is a novel cofactor for regulation of complement by a serpin, C1 inhibitor. Blood. 2016 09 29; 128(13):1766-76.
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Complement and microglia mediate early synapse loss in Alzheimer mouse models. Science. 2016 May 06; 352(6286):712-716.
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Schizophrenia risk from complex variation of complement component 4. Nature. 2016 Feb 11; 530(7589):177-83.
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Classical Complement Pathway Activation in the Kidneys of Women With Preeclampsia. Hypertension. 2015 Jul; 66(1):117-25.