MAP Kinase Kinase 4

"MAP Kinase Kinase 4" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A mitogen-activated protein kinase kinase with specificity for JNK MITOGEN-ACTIVATED PROTEIN KINASES; P38 MITOGEN-ACTIVATED PROTEIN KINASES and the RETINOID X RECEPTORS. It takes part in a SIGNAL TRANSDUCTION pathway that is activated in response to cellular stress.

Descriptor ID

D048670

MeSH Number(s)

D08.811.913.696.620.682.700.565.400

D08.811.913.696.620.682.725.200.400

D12.644.360.440.400

D12.776.476.440.400

Concept/Terms

MAP Kinase Kinase 4

Below are MeSH descriptors whose meaning is more general than "MAP Kinase Kinase 4".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
Protein Kinases [D08.811.913.696.620.682]
Protein-Serine-Threonine Kinases [D08.811.913.696.620.682.700]
Mitogen-Activated Protein Kinase Kinases [D08.811.913.696.620.682.700.565]
MAP Kinase Kinase 4 [D08.811.913.696.620.682.700.565.400]
Protein-Tyrosine Kinases [D08.811.913.696.620.682.725]
Mitogen-Activated Protein Kinase Kinases [D08.811.913.696.620.682.725.200]
MAP Kinase Kinase 4 [D08.811.913.696.620.682.725.200.400]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Mitogen-Activated Protein Kinase Kinases [D12.644.360.440]
MAP Kinase Kinase 4 [D12.644.360.440.400]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Mitogen-Activated Protein Kinase Kinases [D12.776.476.440]
MAP Kinase Kinase 4 [D12.776.476.440.400]

Below are MeSH descriptors whose meaning is related to "MAP Kinase Kinase 4".

Below are MeSH descriptors whose meaning is more specific than "MAP Kinase Kinase 4".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "MAP Kinase Kinase 4" by people in Harvard Catalyst Profiles by year, and whether "MAP Kinase Kinase 4" was a major or minor topic of these publication.

Bar chart showing 107 publications over 29 distinct years, with a maximum of 7 publications in 2006

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1994	2	0	2
1995	2	2	4
1996	2	1	3
1997	2	3	5
1998	3	1	4
1999	0	3	3
2000	3	2	5
2001	1	0	1
2002	1	3	4
2003	0	5	5
2004	0	5	5
2005	3	3	6
2006	3	4	7
2007	1	4	5
2008	2	3	5
2009	1	2	3
2010	0	4	4
2011	0	3	3
2012	0	5	5
2013	1	4	5
2014	1	2	3
2015	2	1	3
2016	0	3	3
2017	1	1	2
2018	1	2	3
2019	2	1	3
2020	1	1	2
2021	0	2	2
2022	0	2	2

Below are the most recent publications written about "MAP Kinase Kinase 4" by people in Profiles.

Phosphorylation of RXRa mediates the effect of JNK to suppress hepatic FGF21 expression and promote metabolic syndrome. Proc Natl Acad Sci U S A. 2022 11; 119(44):e2210434119.

View in: PubMed
NT157 exerts antineoplastic activity by targeting JNK and AXL signaling in lung cancer cells. Sci Rep. 2022 Oct 12; 12(1):17092.

View in: PubMed
Mitogen Kinase Kinase (MKK7) Controls Cytokine Production In Vitro and In Vivo in Mice. Int J Mol Sci. 2021 Aug 29; 22(17).

View in: PubMed
Global profiling of distinct cysteine redox forms reveals wide-ranging redox regulation in C. elegans. Nat Commun. 2021 03 03; 12(1):1415.

View in: PubMed
ß2M Signals Monocytes Through Non-Canonical TGFß Receptor Signal Transduction. Circ Res. 2021 03 05; 128(5):655-669.

View in: PubMed
Discovery of Covalent MKK4/7 Dual Inhibitor. Cell Chem Biol. 2020 12 17; 27(12):1553-1560.e8.

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Dehydration stress alters the mitogen-activated-protein kinase signaling and chaperone stress response in Xenopus laevis. Comp Biochem Physiol B Biochem Mol Biol. 2020 Aug - Sep; 246-247:110461.

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Selective Activation of ZAK ß Expression by 3-Hydroxy-2-Phenylchromone Inhibits Human Osteosarcoma Cells and Triggers Apoptosis via JNK Activation. Int J Mol Sci. 2020 May 09; 21(9).

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A role for cell-autocrine interleukin-2 in regulatory T-cell homeostasis. Immunology. 2020 07; 160(3):295-309.

View in: PubMed
Gomisin A ameliorates metastatic melanoma by inhibiting AMPK and ERK/JNK-mediated cell survival and metastatic phenotypes. Phytomedicine. 2020 Mar; 68:153147.

View in: PubMed

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