Title Associate Professor of Oral Medicine, Infection, and Immunity Institution Harvard School of Dental Medicine Department Oral Med - Infection + Immunity Address Harvard School of Dental Medicine
REB 307
188 Longwood Ave
Boston MA 02115
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Title
Director of DMSc and PhD Programs
Institution
Harvard School of Dental Medicine
Department
Office of Research
Biography
1993
Sanchez Foundation Award for Young Investigators
2005
Harold Frost Young Investigator Award
2007
John Haddad Young Investigator Award
2021
Burton C. Borgelt/SCADA Faculty Advisor Award
Overview
My longstanding interest is to explore the molecular, cellular and genetic basis of skeletal homeostasis and its regulation in health and disease.WNT signaling controls cell fate decision and tissue homeostasis. WNT signaling in bone has been studied intensively in recent years. However, not all key aspects of how it regulates bone mass are clear and the regulation of signaling specificity between different WNT cascades remain puzzling. Given that WNT signaling can be targeted for drug development, insights into these mechanisms might translate into new therapeutic approaches for rare and common skeletal disorders. Ongoing studies on the role of WNT inhibitors and agonists in skeletal homeostasis are part of the current focus of the lab.
Research
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R01DE029615
(GORI, FRANCESCA)
May 8, 2020 - Apr 30, 2025
Biology of cortical bone of long bones and calvarium: Role of Sfrp4 in periosteal bone formation
Role: Principal Investigator
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R56DE028299
(GORI, FRANCESCA)
Aug 1, 2019 - Apr 30, 2020
Biology of cortical bone of long bones and calvarium. Role of Sfrp4 in the local regulation of Wnt signaling
Role: Principal Investigator
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R21DK076093
(GORI, FRANCESCA)
Sep 30, 2006 - May 31, 2009
Role of Wdr5, a Novel BMP-2 Induced Gene, in Limb Development
Role: Principal Investigator
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F32DE005754
(GORI, FRANCESCA)
Sep 15, 2000
BMP-2 REGULATED GENES DURING ENDOCHONDRAL BONE FORMATION
Role: Principal Investigator
Bibliographic
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