Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Martha Elizabeth Shenton, Ph.D.

Concepts (551)

Concepts are derived automatically from a person's publications.
Concepts are listed by decreasing relevance which is based on many factors, including how many publications the person wrote about that topic, how long ago those publications were written, and how many publications other people have written on that same topic.
Name Number of Publications Most Recent Publication Publications by All Authors Concept Score Why?
Schizophrenia2492022688210.140 Why?
Diffusion Tensor Imaging93202323055.400 Why?
Diffusion Magnetic Resonance Imaging70202327374.330 Why?
Schizotypal Personality Disorder3220132884.080 Why?
Temporal Lobe76202016704.020 Why?
Nerve Fibers, Myelinated3920179573.770 Why?
Brain Concussion32202313203.450 Why?
Football2020244603.440 Why?
Corpus Callosum2320217373.150 Why?
Brain1522023263853.050 Why?
Frontal Lobe34202114062.840 Why?
Anisotropy60202212652.680 Why?
Schizophrenic Psychology77201816782.680 Why?
Soccer720221332.580 Why?
Psychotic Disorders42202330462.490 Why?
Brain Mapping88202366692.450 Why?
Image Processing, Computer-Assisted93201989492.290 Why?
Magnetic Resonance Imaging1852023354212.290 Why?
Functional Laterality71201822902.250 Why?
Neural Pathways44202129722.220 Why?
Pattern Recognition, Automated25201310051.940 Why?
Image Interpretation, Computer-Assisted44202033271.910 Why?
Athletic Injuries13202311541.900 Why?
Gyrus Cinguli16201910911.690 Why?
Affective Disorders, Psychotic1620211911.560 Why?
Neuropsychological Tests78202369931.540 Why?
Prefrontal Cortex28202021471.520 Why?
Athletes12202310931.520 Why?
Thalamus11202310231.440 Why?
Limbic System1320214261.430 Why?
Brain Injuries14202220251.430 Why?
Evoked Potentials, Auditory3220205251.380 Why?
Caudate Nucleus720163931.360 Why?
Septum Pellucidum62015581.190 Why?
Event-Related Potentials, P3001420201501.190 Why?
Cognition Disorders36202240431.160 Why?
Parietal Lobe1320218381.150 Why?
Algorithms502018138811.120 Why?
Internal Capsule620141131.040 Why?
Adult29120222140551.030 Why?
Psychiatric Status Rating Scales62201960381.010 Why?
Analysis of Variance42201763651.000 Why?
Imaging, Three-Dimensional25201640420.970 Why?
Male33320233501180.930 Why?
Hockey52017900.890 Why?
Fornix, Brain52012700.890 Why?
Humans46020247443430.860 Why?
Stress Disorders, Post-Traumatic20202342660.850 Why?
Dominance, Cerebral2220106350.840 Why?
Nerve Net16202121740.830 Why?
Hippocampus30202336750.830 Why?
Cerebral Cortex26202257080.830 Why?
Image Enhancement33201629210.800 Why?
Young Adult1032023564300.800 Why?
Intelligence820169200.740 Why?
Artificial Intelligence22201322140.720 Why?
Middle Aged19020242133830.710 Why?
Attention27202224000.700 Why?
DiGeorge Syndrome620171770.700 Why?
Hallucinations820143600.690 Why?
Adolescent1142023857810.690 Why?
Electroencephalography50202261500.660 Why?
Occipital Lobe620213790.640 Why?
Paired-Associate Learning32006520.620 Why?
Auditory Cortex1020203460.610 Why?
Statistics as Topic18201623730.600 Why?
Schizophrenic Language102008690.590 Why?
Corpus Striatum4202012210.580 Why?
Memory18202121740.580 Why?
Chronic Disease46201791460.580 Why?
Post-Concussion Syndrome320152190.580 Why?
Female21220223801940.560 Why?
Evoked Potentials19202010560.540 Why?
Expert Testimony120183560.540 Why?
Nerve Fibers920116870.540 Why?
Delusions220163000.540 Why?
Cognition19202367700.540 Why?
Models, Neurological17201917740.530 Why?
Evoked Potentials, Visual720204270.520 Why?
Myelin Sheath420216520.500 Why?
Sensitivity and Specificity382020147220.460 Why?
Amygdala14201913150.460 Why?
Semantics920135840.460 Why?
Case-Control Studies342022217460.450 Why?
Leukoencephalopathies220132380.450 Why?
Bipolar Disorder16202250270.440 Why?
Brain Chemistry220199810.430 Why?
Military Personnel5202311330.420 Why?
Reproducibility of Results432023199050.420 Why?
Pineal Gland120131660.410 Why?
Sex Characteristics7202125850.410 Why?
Perforant Pathway22009240.410 Why?
Signal Processing, Computer-Assisted13201915340.400 Why?
Intracranial Hemorrhages220148550.400 Why?
Nerve Regeneration120177880.400 Why?
Disease Progression152021132840.390 Why?
Organ Size9202122520.390 Why?
Schizophrenia, Paranoid120111040.380 Why?
Gait Disorders, Neurologic120132310.370 Why?
Visual Perception9200814200.370 Why?
Neurodegenerative Diseases5202310610.370 Why?
Memory Disorders8201511840.350 Why?
Pituitary-Adrenal System120135530.350 Why?
Cluster Analysis5202127150.350 Why?
Veterans7202225190.340 Why?
Hypothalamo-Hypophyseal System120137030.330 Why?
Brain Diseases4201215630.330 Why?
Williams Syndrome420121870.320 Why?
Cerebellum5201414880.320 Why?
Problem Solving320064400.320 Why?
Mental Recall8201412050.320 Why?
Reaction Time25201720970.320 Why?
Parahippocampal Gyrus520161160.310 Why?
Attention Deficit Disorder with Hyperactivity4202036580.310 Why?
Language6202114710.310 Why?
Acoustic Stimulation22202012160.300 Why?
Subtraction Technique420165250.300 Why?
Cerebral Ventricles720055440.300 Why?
Combat Disorders720073020.300 Why?
22q11 Deletion Syndrome22018170.290 Why?
Aging7202186640.290 Why?
Lateral Ventricles220191460.290 Why?
Intelligence Tests520165050.290 Why?
Depressive Disorder, Major5201846440.290 Why?
Occupational Diseases1201514710.290 Why?
Schizoid Personality Disorder12006140.280 Why?
Language Disorders420131410.280 Why?
Reference Values18200849820.270 Why?
Association Learning120062240.260 Why?
Intracranial Aneurysm1201411970.250 Why?
Ganglioglioma12004420.250 Why?
Dopamine2201015910.250 Why?
Periaqueductal Gray220041070.250 Why?
Social Behavior3201211270.240 Why?
Artifacts4201819040.240 Why?
Executive Function5202213640.240 Why?
Embolization, Therapeutic1201413920.240 Why?
Water5201913950.240 Why?
Magic12003120.240 Why?
Social Perception320184250.240 Why?
Verbal Learning620134670.230 Why?
Mood Disorders3200811060.230 Why?
Diffusion720168330.230 Why?
Illusions12003600.230 Why?
Visual Pathways420135650.220 Why?
Niemann-Pick Disease, Type C12023510.220 Why?
Wechsler Scales920162600.220 Why?
Friedreich Ataxia22013760.220 Why?
Psychomotor Performance8202119010.220 Why?
Antipsychotic Agents10201430570.210 Why?
Diagnostic Imaging3201835070.210 Why?
Carbolines120232650.210 Why?
Risk10202196870.200 Why?
Brain Injury, Chronic22012680.200 Why?
Cerebellar Nuclei12021520.200 Why?
Cognitive Reserve12022760.200 Why?
Statistics, Nonparametric6201728860.190 Why?
Thinking820053190.190 Why?
Choroid Plexus120232310.180 Why?
Head Injuries, Closed220181360.180 Why?
Longitudinal Studies172021139890.170 Why?
Auditory Perception620095690.170 Why?
Auditory Perceptual Disorders22010360.170 Why?
Echo-Planar Imaging120046590.170 Why?
Software5201644430.170 Why?
Arousal7200611650.170 Why?
Epilepsy, Temporal Lobe120234030.170 Why?
Pattern Recognition, Visual720088240.170 Why?
Glasgow Coma Scale220185700.170 Why?
Glyburide120191130.170 Why?
Nerve Degeneration220147480.170 Why?
Computer Simulation11201861960.160 Why?
Jurisprudence120181100.160 Why?
Age Factors92021183700.160 Why?
User-Computer Interface4201614310.160 Why?
Age of Onset5201532710.160 Why?
Information Storage and Retrieval520168240.160 Why?
Delphi Technique120217780.160 Why?
Models, Statistical10201251020.160 Why?
Neuregulin-1220161420.150 Why?
Demyelinating Diseases220133540.150 Why?
Magnetic Resonance Spectroscopy4202037600.150 Why?
Substantia Nigra120193530.150 Why?
Diagnostic and Statistical Manual of Mental Disorders6201119530.150 Why?
Aged3320241632800.150 Why?
Supreme Court Decisions120181280.150 Why?
Pitch Perception320091140.150 Why?
Sex Factors122014103970.140 Why?
Social Behavior Disorders12017970.140 Why?
tau Proteins3202318680.140 Why?
China5202022480.140 Why?
Mathematical Concepts12016630.140 Why?
Craniocerebral Trauma120214820.140 Why?
Severity of Illness Index132020155400.140 Why?
Dementia3202325180.140 Why?
Diseases in Twins320074490.140 Why?
Neostriatum120172500.140 Why?
Adult Survivors of Child Abuse120192600.140 Why?
Normal Distribution320112800.140 Why?
Cerebrospinal Fluid420065340.130 Why?
Decision Making1201038870.130 Why?
Pilot Projects6202083240.130 Why?
Olfactory Pathways320111210.130 Why?
Reading720045580.130 Why?
Tauopathies120193070.130 Why?
Inflammation12015106380.130 Why?
Orientation220063270.130 Why?
Iron1202317740.130 Why?
Ketamine120205000.120 Why?
Space Perception320114750.120 Why?
Longevity2201910700.120 Why?
Atlases as Topic120162360.120 Why?
Atrophy7201715830.120 Why?
Obsessive-Compulsive Disorder2201514440.120 Why?
Physical Education and Training120141060.120 Why?
Cross-Sectional Studies102019250430.120 Why?
Dyslexia120162480.120 Why?
Social Adjustment119966310.120 Why?
Anomia11993140.120 Why?
Pitch Discrimination32008390.120 Why?
Auditory Pathways220142330.120 Why?
Olfactory Bulb220112000.110 Why?
Polymorphism, Single Nucleotide52017155190.110 Why?
Child192022777090.110 Why?
Endophenotypes220172500.110 Why?
Models, Theoretical7202135890.110 Why?
Pons120142450.110 Why?
Follow-Up Studies112021390500.110 Why?
Neocortex220074000.110 Why?
Myelin Proteins120132150.110 Why?
Positron-Emission Tomography4202362340.110 Why?
Paresis120141790.110 Why?
Probability3201125050.110 Why?
Pyramidal Tracts220142560.110 Why?
Memory, Short-Term420239750.110 Why?
Facial Expression220205080.110 Why?
Glutamic Acid2201411690.110 Why?
Verbal Behavior520023390.110 Why?
Parvalbumins120142500.110 Why?
Cues520118730.110 Why?
Cerebrum120131370.110 Why?
Alzheimer Disease2202380370.100 Why?
Nervous System Diseases1200216220.100 Why?
Postoperative Complications12014152950.100 Why?
Regression Analysis4201864590.100 Why?
Socioeconomic Factors5201877850.100 Why?
Disorders of Excessive Somnolence120152710.100 Why?
Consensus1202129590.100 Why?
Swimming120122060.100 Why?
Universities220189560.100 Why?
Pyramidal Cells120143630.100 Why?
Visual Fields1199810470.100 Why?
Olfaction Disorders220112220.100 Why?
Control Groups220081050.100 Why?
Complementary Therapies120154860.100 Why?
Dichotic Listening Tests22009220.100 Why?
Natural Language Processing3201610410.100 Why?
Kruppel-Like Transcription Factors120145040.100 Why?
Movement Disorders120144450.090 Why?
Glutamine120145780.090 Why?
Body Water120123430.090 Why?
Models, Animal1201721710.090 Why?
Extracellular Fluid120121670.090 Why?
Germany120128620.090 Why?
Feedback, Sensory12010550.090 Why?
Occupations120125170.090 Why?
Models, Anatomic220136910.090 Why?
Physical Stimulation320015250.090 Why?
Least-Squares Analysis220023790.090 Why?
Stochastic Processes120113440.090 Why?
Cortical Synchronization22008790.090 Why?
Hospitalization112019102620.090 Why?
Neurologic Examination320239300.090 Why?
Mathematical Computing320031470.090 Why?
Cohort Studies62022405610.090 Why?
Leukomalacia, Periventricular120101840.090 Why?
Psychological Theory120101680.090 Why?
Neurons4201493380.090 Why?
Contingent Negative Variation12009340.090 Why?
Prosopagnosia32006600.090 Why?
Photic Stimulation5202020250.080 Why?
Personality Inventory4200610300.080 Why?
Family3200931470.080 Why?
Erythropoietin120137260.080 Why?
Rats, Sprague-Dawley2201783010.080 Why?
Brief Psychiatric Rating Scale420131080.080 Why?
Scalp720043800.080 Why?
Herpes Simplex120124700.080 Why?
Chi-Square Distribution3201035080.080 Why?
Reward120149410.080 Why?
Health Education1201410560.080 Why?
Motor Cortex220149860.080 Why?
Time Perception12008840.080 Why?
Anxiety3202142970.080 Why?
Headache1201512260.070 Why?
Family Health1201212820.070 Why?
Neural Inhibition420106020.070 Why?
Twins, Monozygotic520074580.070 Why?
Face420079940.070 Why?
Axons3202116840.070 Why?
Emotions3202026610.070 Why?
Form Perception420021820.070 Why?
Task Performance and Analysis320097800.070 Why?
Molecular Imaging120148280.070 Why?
Child of Impaired Parents120104550.070 Why?
Anatomy, Cross-Sectional120061410.070 Why?
Mental Disorders3201966000.070 Why?
Stereotyped Behavior120061360.070 Why?
Speech Perception420104890.070 Why?
Genetic Predisposition to Disease72017174460.070 Why?
Muscle, Skeletal1200149310.070 Why?
Sleep Initiation and Maintenance Disorders1201510040.070 Why?
Cerebral Palsy120104590.070 Why?
Fourier Analysis220084470.070 Why?
Reference Standards2200710250.070 Why?
Extracellular Space220195940.070 Why?
Sensory Thresholds220103910.070 Why?
Motor Neurons120108440.070 Why?
Linear Models4202259520.070 Why?
Data Interpretation, Statistical3201127160.070 Why?
Models, Biological4201295830.070 Why?
Hearing120094820.060 Why?
Diabetes Mellitus, Type 232014117250.060 Why?
United States Department of Veterans Affairs120098750.060 Why?
Trail Making Test22017570.060 Why?
Animals620191687570.060 Why?
Infant, Newborn42020256250.060 Why?
Expert Systems22002810.060 Why?
Impulsive Behavior120073160.060 Why?
Twins120063390.060 Why?
Depression4201577660.060 Why?
Reality Testing12003260.060 Why?
Diagnosis, Differential122006129590.060 Why?
Stress, Psychological2201842450.060 Why?
Receptors, Cell Surface1201328660.060 Why?
Aged, 80 and over102022577760.060 Why?
Electrophysiology3200413080.060 Why?
Psychology120053560.060 Why?
Transcranial Magnetic Stimulation3201014320.060 Why?
Movement3201414710.060 Why?
Nerve Tissue Proteins2201344620.060 Why?
Personality120075520.060 Why?
Brain Neoplasms1200488630.060 Why?
Blinking120031380.060 Why?
Habituation, Psychophysiologic120031540.060 Why?
Substance Withdrawal Syndrome120076320.050 Why?
Nicotine120076810.050 Why?
Health Expenditures1201523480.050 Why?
Cadmium120232120.050 Why?
Prospective Studies72021532880.050 Why?
Multivariate Analysis42022122450.050 Why?
Comorbidity52018103880.050 Why?
Mental Processes320042490.050 Why?
Heart Defects, Congenital1201845840.050 Why?
Tomography, X-Ray Computed32002201290.050 Why?
MicroRNAs2201437520.050 Why?
Optic Nerve120045540.050 Why?
United States42021698720.050 Why?
Rats12017242600.050 Why?
Amyloid beta-Peptides2202335870.050 Why?
Genotype42017129510.050 Why?
Behavior320135610.050 Why?
Signal Detection, Psychological12000850.050 Why?
Entropy220142090.050 Why?
Cephalometry120023820.050 Why?
Neuroprotective Agents220199410.040 Why?
Neurobehavioral Manifestations11999100.040 Why?
Receptors, N-Methyl-D-Aspartate320018950.040 Why?
Noise120022790.040 Why?
Time Factors42015400750.040 Why?
Mental Status Schedule220143210.040 Why?
Child, Preschool32021410060.040 Why?
Acute Disease3201871490.040 Why?
Visual Cortex3200811490.040 Why?
Word Association Tests11998570.040 Why?
Rest220189010.040 Why?
Risk Factors92023722900.040 Why?
Smell220112440.040 Why?
Statistical Distributions22009640.040 Why?
Neural Analyzers1199830.040 Why?
Stroop Test12018620.040 Why?
Geniculate Bodies120001630.040 Why?
Electronic Health Records2201244680.040 Why?
Contrast Sensitivity120002440.040 Why?
Autopsy1202210200.040 Why?
Motion Perception220004080.040 Why?
Amyloid120237950.040 Why?
Ethylene Glycols120191560.040 Why?
Medical Illustration119991330.040 Why?
Perception1200411980.040 Why?
Affect2202114760.040 Why?
Education120215430.040 Why?
Death120226780.040 Why?
Predictive Value of Tests22021150760.040 Why?
Oxygen3201641890.040 Why?
Anatomy119991120.040 Why?
Medical Informatics Applications119991860.040 Why?
Psychometrics6200730020.040 Why?
Databases, Factual3201977290.040 Why?
Numerical Analysis, Computer-Assisted220071250.040 Why?
Electromagnetic Fields119982980.030 Why?
Registries1201280890.030 Why?
Membrane Proteins1201378800.030 Why?
Vietnam220074080.030 Why?
Demography1202116560.030 Why?
Percussion12015180.030 Why?
Plaque, Amyloid120197290.030 Why?
Antidepressive Agents2202028380.030 Why?
Brain Edema120196170.030 Why?
Evoked Potentials, Motor220104540.030 Why?
Smoking2201189870.030 Why?
Prognosis32020290630.030 Why?
Putamen119952910.030 Why?
Syndrome1202132510.030 Why?
Infusions, Intravenous1201922740.030 Why?
Globus Pallidus119952530.030 Why?
Interpersonal Relations2202114250.030 Why?
Multifactorial Inheritance1202211940.030 Why?
Disease Susceptibility1202117820.030 Why?
Physicians1201245670.030 Why?
Perceptual Disorders119961960.030 Why?
Aniline Compounds120199860.030 Why?
Interleukin-61202432000.030 Why?
Australia1201711700.030 Why?
Area Under Curve1201816540.030 Why?
Motor Activity1200427140.030 Why?
Equipment Failure Analysis120168680.030 Why?
Language Tests120132000.030 Why?
Self Report2201435580.030 Why?
Body Fluid Compartments11992520.030 Why?
Glial Fibrillary Acidic Protein120145280.030 Why?
Macaca mulatta1201923750.030 Why?
GPI-Linked Proteins120134340.030 Why?
Feasibility Studies2201250780.030 Why?
Myelin-Associated Glycoprotein120121130.030 Why?
Mathematics220047280.030 Why?
Amnesia119932480.020 Why?
Choice Behavior220078030.020 Why?
Retrospective Studies52021774490.020 Why?
Dinoprostone120146000.020 Why?
School Health Services120143750.020 Why?
Receptor, Notch1120145020.020 Why?
Interview, Psychological120148120.020 Why?
Survivors1200122910.020 Why?
Rorschach Test12010260.020 Why?
Microcomputers119901470.020 Why?
Musculoskeletal Diseases120165810.020 Why?
Prevalence12007152260.020 Why?
Psychomotor Disorders120101520.020 Why?
Brain Stem120158460.020 Why?
Wnt Proteins120147210.020 Why?
Entorhinal Cortex120112720.020 Why?
Psychoacoustics12009570.020 Why?
Tissue Distribution1201423270.020 Why?
Life Change Events220079380.020 Why?
Neural Conduction120104400.020 Why?
Fixation, Ocular120112510.020 Why?
Endothelial Cells1202234790.020 Why?
Radiopharmaceuticals1201926450.020 Why?
Cytoskeleton1201411850.020 Why?
Bone Morphogenetic Proteins120148380.020 Why?
Oligodendroglia120125170.020 Why?
Canada1201420650.020 Why?
Psychological Tests119906510.020 Why?
Cerebral Hemorrhage1201926470.020 Why?
Equipment Design1201635820.020 Why?
Risk Assessment22019233380.020 Why?
Brain Damage, Chronic119882650.020 Why?
Skin Absorption12007940.020 Why?
Psychophysics120083090.020 Why?
Twin Studies as Topic120071050.020 Why?
Lithium Carbonate120071840.020 Why?
Gene Frequency1201335880.020 Why?
Remission Induction1201223860.020 Why?
Comprehension120126100.020 Why?
Basic Helix-Loop-Helix Transcription Factors1201211140.020 Why?
Phenotype22020163650.020 Why?
Extracellular Matrix1201417410.020 Why?
Herpesvirus 1, Human120127430.020 Why?
Transforming Growth Factor beta1201420070.020 Why?
Manuals as Topic11986980.020 Why?
Neurotic Disorders12005790.020 Why?
Double-Blind Method12019120260.020 Why?
Administration, Cutaneous120077110.020 Why?
Trauma Severity Indices120074810.020 Why?
Poisson Distribution120065130.020 Why?
Genomics1202057200.020 Why?
Valproic Acid120074450.020 Why?
DNA Mutational Analysis1201341860.020 Why?
Loudness Perception12003240.020 Why?
Genetic Association Studies1201327030.010 Why?
Psycholinguistics12004780.010 Why?
Gambling120072500.010 Why?
Neurosurgical Procedures1201520020.010 Why?
ROC Curve1201135270.010 Why?
Psychophysiology120031350.010 Why?
Medical Records1198914130.010 Why?
Antimanic Agents120075220.010 Why?
Personality Assessment120056470.010 Why?
Electrooculography219931180.010 Why?
Radiography2201070230.010 Why?
Factor Analysis, Statistical120059770.010 Why?
Confusion120042750.010 Why?
Particle Size1200716420.010 Why?
Periodicity120033630.010 Why?
Tobacco Use Disorder120076880.010 Why?
Curriculum1201436050.010 Why?
Pandemics1202183880.010 Why?
Homeostasis1201233400.010 Why?
Signal Transduction22014234030.010 Why?
Genetic Testing1201334440.010 Why?
Depressive Disorder2199937480.010 Why?
Phantoms, Imaging1200824800.010 Why?
Immunoglobulin G1201245600.010 Why?
Health Knowledge, Attitudes, Practice1201439230.010 Why?
Electric Stimulation1200417670.010 Why?
Hypermedia11999210.010 Why?
Bayes Theorem1200723090.010 Why?
Electromyography1200313790.010 Why?
Insulin Resistance1201238640.010 Why?
Data Display119991820.010 Why?
Patient Selection1201042150.010 Why?
Receptors, GABA119992880.010 Why?
Gene Expression Profiling1201494380.010 Why?
Apoptosis1201497270.010 Why?
Electrocardiography1201164420.010 Why?
Computer Systems119994830.010 Why?
Social Class1200619990.010 Why?
Computer Graphics119993610.010 Why?
Therapy, Computer-Assisted119992740.010 Why?
Incidence12014209470.010 Why?
Treatment Outcome22013631140.010 Why?
Patient Admission1200313800.010 Why?
Basal Ganglia119985460.010 Why?
Heart Rate1200640910.010 Why?
Odds Ratio1200798490.010 Why?
Lasers119989520.010 Why?
Differential Threshold11993800.010 Why?
Patient Care Planning119999210.010 Why?
Alcoholism1200219060.010 Why?
Hospitals, Psychiatric119933320.010 Why?
Color Perception119922130.010 Why?
Electrodes119936190.010 Why?
Eye Movements119935070.010 Why?
Research Design2200059870.010 Why?
Ear119901730.010 Why?
Electrodes, Implanted119938240.000 Why?
Surgical Procedures, Operative1199918760.000 Why?
Nose119905090.000 Why?
Substance-Related Disorders1200242580.000 Why?
Emergency Service, Hospital1200176590.000 Why?
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.