"Endophenotypes" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Measurable biological (physiological, biochemical, and anatomical features), behavioral (psychometric pattern) or cognitive markers that are found more often in individuals with a disease than in the general population. Because many endophenotypes are present before the disease onset and in individuals with heritable risk for disease such as unaffected family members, they can be used to help diagnose and search for causative genes.
Below are MeSH descriptors whose meaning is more general than "Endophenotypes".
Below are MeSH descriptors whose meaning is more specific than "Endophenotypes".
This graph shows the total number of publications written about "Endophenotypes" by people in Harvard Catalyst Profiles by year, and whether "Endophenotypes" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2009 | 2 | 0 | 2 |
| 2010 | 3 | 0 | 3 |
| 2011 | 2 | 1 | 3 |
| 2012 | 4 | 4 | 8 |
| 2013 | 7 | 6 | 13 |
| 2014 | 9 | 9 | 18 |
| 2015 | 10 | 7 | 17 |
| 2016 | 9 | 3 | 12 |
| 2017 | 2 | 8 | 10 |
| 2018 | 4 | 4 | 8 |
| 2019 | 2 | 3 | 5 |
| 2020 | 4 | 2 | 6 |
| 2021 | 2 | 4 | 6 |
| 2022 | 2 | 5 | 7 |
| 2023 | 0 | 3 | 3 |
Below are the most recent publications written about "Endophenotypes" by people in Profiles.
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A phenome-wide association study (PheWAS) to identify the health impacts of 4-cresol sulfate in the Nagahama Study. Sci Rep. 2023 08 25; 13(1):13926.
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Association between Neuroligin-1 polymorphism and plasma glutamine levels in individuals with autism spectrum disorder. EBioMedicine. 2023 Sep; 95:104746.
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Sensitivity of Schizophrenia Endophenotype Biomarkers to Anticholinergic Medication Burden. Am J Psychiatry. 2023 07 01; 180(7):519-523.
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Precision Effects of Glibenclamide on MRI Endophenotypes in Clinically Relevant Murine Traumatic Brain Injury. Crit Care Med. 2023 02 01; 51(2):e45-e59.
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Genetically predicted telomere length and Alzheimer's disease endophenotypes: a Mendelian randomization study. Alzheimers Res Ther. 2022 Nov 07; 14(1):167.
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Quantitative trait locus analysis for endophenotypes reveals genetic substrates of core symptom domains and neurocognitive function in autism spectrum disorder. Transl Psychiatry. 2022 09 24; 12(1):407.
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Brain structural abnormalities of the associative striatum in adolescents and young adults at genetic high-risk of schizophrenia: Implications for illness endophenotypes. J Psychiatr Res. 2022 Nov; 155:355-362.
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Endophenotype effect sizes support variant pathogenicity in monogenic disease susceptibility genes. Nat Commun. 2022 08 30; 13(1):5106.
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Genetic and environment effects on structural neuroimaging endophenotype for bipolar disorder: a novel molecular approach. Transl Psychiatry. 2022 04 04; 12(1):137.
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Psychosis Biotypes: Replication and Validation from the B-SNIP Consortium. Schizophr Bull. 2022 01 21; 48(1):56-68.