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Emma Catherine Fink, M.D.

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  1. F30CA199988 (FINK, EMMA CATHERINE) Aug 1, 2015 - Jul 31, 2017
    NIH
    Dissecting CRBN-substrate interactions in the mechanism of lenalidomide
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Slabicki M, Kozicka Z, Petzold G, Li YD, Manojkumar M, Bunker RD, Donovan KA, Sievers QL, Koeppel J, Suchyta D, Sperling AS, Fink EC, Gasser JA, Wang LR, Corsello SM, Sellar RS, Jan M, Gillingham D, Scholl C, Fröhling S, Golub TR, Fischer ES, Thomä NH, Ebert BL. The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K. Nature. 2020 09; 585(7824):293-297. PMID: 32494016.
    Citations: 8     Fields:    Translation:HumansCells
  2. Sperling AS, Burgess M, Keshishian H, Gasser JA, Bhatt S, Jan M, Slabicki M, Sellar RS, Fink EC, Miller PG, Liddicoat BJ, Sievers QL, Sharma R, Adams DN, Olesinski EA, Fulciniti M, Udeshi ND, Kuhn E, Letai A, Munshi NC, Carr SA, Ebert BL. Patterns of substrate affinity, competition, and degradation kinetics underlie biological activity of thalidomide analogs. Blood. 2019 07 11; 134(2):160-170. PMID: 31043423.
    Citations: 3     Fields:    Translation:HumansCells
  3. Donovan KA, An J, Nowak RP, Yuan JC, Fink EC, Berry BC, Ebert BL, Fischer ES. Thalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray syndrome. Elife. 2018 08 01; 7. PMID: 30067223.
    Citations: 40     Fields:    Translation:HumansCells
  4. Fink EC, McConkey M, Adams DN, Haldar SD, Kennedy JA, Guirguis AA, Udeshi ND, Mani DR, Chen M, Liddicoat B, Svinkina T, Nguyen AT, Carr SA, Ebert BL. CrbnI391V is sufficient to confer in vivo sensitivity to thalidomide and its derivatives in mice. Blood. 2018 10 04; 132(14):1535-1544. PMID: 30064974.
    Citations: 11     Fields:    Translation:Animals
  5. Fink EC, Ebert BL. The novel mechanism of lenalidomide activity. Blood. 2015 Nov 19; 126(21):2366-9. PMID: 26438514.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  6. Krönke J, Fink EC, Hollenbach PW, MacBeth KJ, Hurst SN, Udeshi ND, Chamberlain PP, Mani DR, Man HW, Gandhi AK, Svinkina T, Schneider RK, McConkey M, Järås M, Griffiths E, Wetzler M, Bullinger L, Cathers BE, Carr SA, Chopra R, Ebert BL. Lenalidomide induces ubiquitination and degradation of CK1a in del(5q) MDS. Nature. 2015 Jul 09; 523(7559):183-188. PMID: 26131937.
    Citations: 164     Fields:    Translation:HumansAnimalsCells
  7. Järås M, Miller PG, Chu LP, Puram RV, Fink EC, Schneider RK, Al-Shahrour F, Peña P, Breyfogle LJ, Hartwell KA, McConkey ME, Cowley GS, Root DE, Kharas MG, Mullally A, Ebert BL. Csnk1a1 inhibition has p53-dependent therapeutic efficacy in acute myeloid leukemia. J Exp Med. 2014 Apr 07; 211(4):605-12. PMID: 24616378.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  8. Fink EC, Fisher DE. BRAF and MC1R in melanoma: different in head and neck tumors? J Invest Dermatol. 2013 Apr; 133(4):878-80. PMID: 23486431.
    Citations:    Fields:    Translation:Humans
  9. Yu Q, Kuzmiak H, Olsen L, Kulkarni A, Fink E, Zou Y, Bi X. Saccharomyces cerevisiae Esc2p interacts with Sir2p through a small ubiquitin-like modifier (SUMO)-binding motif and regulates transcriptionally silent chromatin in a locus-dependent manner. J Biol Chem. 2010 Mar 05; 285(10):7525-36. PMID: 20048165.
    Citations: 5     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.