Harvard Catalyst Profiles

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Zongqi Xia, M.D.,Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01NS098023 (XIA, ZONGQI) Sep 30, 2016 - Jun 30, 2021
    Integrating EHR and Genomics to Predict Multiple Sclerosis Drug Response
    Role: Principal Investigator
  2. K08NS079493 (XIA, ZONGQI) Mar 10, 2016 - Dec 31, 2015
    Leveraging genetics and environment to predict presymptomatic multiple sclerosis
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Ahuja Y, Kim N, Liang L, Cai T, Dahal K, Seyok T, Lin C, Finan S, Liao K, Savovoa G, Chitnis T, Cai T, Xia Z. Leveraging electronic health records data to predict multiple sclerosis disease activity. Ann Clin Transl Neurol. 2021 Feb 24. PMID: 33626237.
    Citations:    Fields:    
  2. Klann JG, Weber GM, Estiri H, Moal B, Avillach P, Hong C, Castro V, Maulhardt T, Tan ALM, Geva A, Beaulieu-Jones BK, Malovini A, South AM, Visweswaran S, Omenn GS, Ngiam KY, Mandl KD, Boeker M, Olson KL, Mowery DL, Morris M, Follett RW, Hanauer DA, Bellazzi R, Moore JH, Loh NW, Bell DS, Wagholikar KB, Chiovato L, Tibollo V, Rieg S, Li ALLJ, Jouhet V, Schriver E, Samayamuthu MJ, Xia Z, Hutch M, Luo Y, Kohane IS, Brat GA, Murphy SN. Validation of an Internationally Derived Patient Severity Phenotype to Support COVID-19 Analytics from Electronic Health Record Data. J Am Med Inform Assoc. 2021 Feb 10. PMID: 33566082.
    Citations: 1     Fields:    
  3. Weber GM, Hong C, Palmer NP, Avillach P, Murphy SN, Gutiérrez-Sacristán A, Xia Z, Serret-Larmande A, Neuraz A, Omenn GS, Visweswaran S, Klann JG, South AM, Loh NHW, Cannataro M, Beaulieu-Jones BK, Bellazzi R, Agapito G, Alessiani M, Aronow BJ, Bell DS, Bellasi A, Benoit V, Beraghi M, Boeker M, Booth J, Bosari S, Bourgeois FT, Brown NW, Bucalo M, Chiovato L, Chiudinelli L, Dagliati A, Devkota B, DuVall SL, Follett RW, Ganslandt T, García Barrio N, Gradinger T, Griffier R, Hanauer DA, Holmes JH, Horki P, Huling KM, Issitt RW, Jouhet V, Keller MS, Kraska D, Liu M, Luo Y, Lynch KE, Malovini A, Mandl KD, Mao C, Maram A, Matheny ME, Maulhardt T, Mazzitelli M, Milano M, Moore JH, Morris JS, Morris M, Mowery DL, Naughton TP, Ngiam KY, Norman JB, Patel LP, Pedrera Jimenez M, Ramoni RB, Schriver ER, Scudeller L, Sebire NJ, Serrano Balazote P, Spiridou A, Tan AL, Tan BW, Tibollo V, Torti C, Trecarichi EM, Vitacca M, Zambelli A, Zucco C, Kohane IS, Cai T, Brat GA. International Comparisons of Harmonized Laboratory Value Trajectories to Predict Severe COVID-19: Leveraging the 4CE Collaborative Across 342 Hospitals and 6 Countries: A Retrospective Cohort Study. medRxiv. 2021 Feb 05. PMID: 33564777.
  4. Zhang T, Goodman M, Zhu F, Healy B, Carruthers R, Chitnis T, Weiner H, Cai T, De Jager P, Tremlett H, Xia Z. Phenome-wide examination of comorbidity burden and multiple sclerosis disease severity. Neurol Neuroimmunol Neuroinflamm. 2020 11; 7(6). PMID: 32817202.
    Citations:    Fields:    
  5. Levin SN, Riley CS, Dhand A, White CC, Venkatesh S, Boehm B, Nassif C, Socia L, Onomichi K, Leavitt VM, Levine L, Heyman R, Farber RS, Vargas WS, Xia Z, De Jager PL. Association of social network structure and physical function in patients with multiple sclerosis. Neurology. 2020 09 15; 95(11):e1565-e1574. PMID: 32769139.
    Citations:    Fields:    Translation:Humans
  6. Sonabend W A, Cai W, Ahuja Y, Ananthakrishnan A, Xia Z, Yu S, Hong C. Automated ICD coding via unsupervised knowledge integration (UNITE). Int J Med Inform. 2020 07; 139:104135. PMID: 32361145.
    Citations: 1     Fields:    Translation:Humans
  7. Zhang Y, Cai T, Yu S, Cho K, Hong C, Sun J, Huang J, Ho YL, Ananthakrishnan AN, Xia Z, Shaw SY, Gainer V, Castro V, Link N, Honerlaw J, Huang S, Gagnon D, Karlson EW, Plenge RM, Szolovits P, Savova G, Churchill S, O'Donnell C, Murphy SN, Gaziano JM, Kohane I, Cai T, Liao KP. High-throughput phenotyping with electronic medical record data using a common semi-supervised approach (PheCAP). Nat Protoc. 2019 12; 14(12):3426-3444. PMID: 31748751.
    Citations: 11     Fields:    Translation:Humans
  8. Dhand A, White CC, Johnson C, Xia Z, De Jager PL. A scalable online tool for quantitative social network assessment reveals potentially modifiable social environmental risks. Nat Commun. 2018 09 26; 9(1):3930. PMID: 30258103.
    Citations: 8     Fields:    Translation:HumansCTClinical Trials
  9. Kowalec K, Wright GEB, Drögemöller BI, Aminkeng F, Bhavsar AP, Kingwell E, Yoshida EM, Traboulsee A, Marrie RA, Kremenchutzky M, Campbell TL, Duquette P, Chalasani N, Wadelius M, Hallberg P, Xia Z, De Jager PL, Denny JC, Davis MF, Ross CJD, Tremlett H, Carleton BC. Common variation near IRF6 is associated with IFN-ß-induced liver injury in multiple sclerosis. Nat Genet. 2018 08; 50(8):1081-1085. PMID: 30013178.
    Citations: 6     Fields:    Translation:Humans
  10. Manners J, Jadhav AP, Xia Z. Mystery Case: A 61-year-old woman with lower extremity paralysis and sensory loss. Neurology. 2017 11 28; 89(22):e257-e263. PMID: 29180581.
    Citations:    Fields:    Translation:Humans
  11. Xia Z, Friedlander RM. Minocycline in Multiple Sclerosis - Compelling Results but Too Early to Tell. N Engl J Med. 2017 06 01; 376(22):2191-2193. PMID: 28564559.
    Citations:    Fields:    
  12. Xia Z, Steele SU, Bakshi A, Clarkson SR, White CC, Schindler MK, Nair G, Dewey BE, Price LR, Ohayon J, Chibnik LB, Cortese IC, De Jager PL, Reich DS. Assessment of Early Evidence of Multiple Sclerosis in a Prospective Study of Asymptomatic High-Risk Family Members. JAMA Neurol. 2017 03 01; 74(3):293-300. PMID: 28114441.
    Citations: 10     Fields:    Translation:Humans
  13. Bargiela D, Bianchi MT, Westover MB, Chibnik LB, Healy BC, De Jager PL, Xia Z. Selection of first-line therapy in multiple sclerosis using risk-benefit decision analysis. Neurology. 2017 Feb 14; 88(7):677-684. PMID: 28087821.
    Citations: 3     Fields:    Translation:Humans
  14. Bove R, Chua AS, Xia Z, Chibnik L, De Jager PL, Chitnis T. Complex relation of HLA-DRB1*1501, age at menarche, and age at multiple sclerosis onset. Neurol Genet. 2016 Aug; 2(4):e88. PMID: 27504495.
    Citations: 8     
  15. Xia Z, White CC, Owen EK, Von Korff A, Clarkson SR, McCabe CA, Cimpean M, Winn PA, Hoesing A, Steele SU, Cortese IC, Chitnis T, Weiner HL, Reich DS, Chibnik LB, De Jager PL. Genes and Environment in Multiple Sclerosis project: A platform to investigate multiple sclerosis risk. Ann Neurol. 2016 Feb; 79(2):178-89. PMID: 26583565.
    Citations: 13     Fields:    Translation:Humans
  16. Liao KP, Ananthakrishnan AN, Kumar V, Xia Z, Cagan A, Gainer VS, Goryachev S, Chen P, Savova GK, Agniel D, Churchill S, Lee J, Murphy SN, Plenge RM, Szolovits P, Kohane I, Shaw SY, Karlson EW, Cai T. Methods to Develop an Electronic Medical Record Phenotype Algorithm to Compare the Risk of Coronary Artery Disease across 3 Chronic Disease Cohorts. PLoS One. 2015; 10(8):e0136651. PMID: 26301417.
    Citations: 31     Fields:    Translation:Humans
  17. Liao KP, Cai T, Savova GK, Murphy SN, Karlson EW, Ananthakrishnan AN, Gainer VS, Shaw SY, Xia Z, Szolovits P, Churchill S, Kohane I. Development of phenotype algorithms using electronic medical records and incorporating natural language processing. BMJ. 2015 Apr 24; 350:h1885. PMID: 25911572.
    Citations: 70     Fields:    Translation:Humans
  18. Xia Z, Secor E, Chibnik LB, Bove RM, Cheng S, Chitnis T, Cagan A, Gainer VS, Chen PJ, Liao KP, Shaw SY, Ananthakrishnan AN, Szolovits P, Weiner HL, Karlson EW, Murphy SN, Savova GK, Cai T, Churchill SE, Plenge RM, Kohane IS, De Jager PL. Modeling disease severity in multiple sclerosis using electronic health records. PLoS One. 2013; 8(11):e78927. PMID: 24244385.
    Citations: 28     Fields:    Translation:HumansCTClinical Trials
  19. Ottoboni L, Frohlich IY, Lee M, Healy BC, Keenan BT, Xia Z, Chitnis T, Guttmann CR, Khoury SJ, Weiner HL, Hafler DA, De Jager PL. Clinical relevance and functional consequences of the TNFRSF1A multiple sclerosis locus. Neurology. 2013 Nov 26; 81(22):1891-9. PMID: 24174586.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  20. Ananthakrishnan AN, Cagan A, Gainer VS, Cai T, Cheng SC, Savova G, Chen P, Szolovits P, Xia Z, De Jager PL, Shaw SY, Churchill S, Karlson EW, Kohane I, Plenge RM, Murphy SN, Liao KP. Normalization of plasma 25-hydroxy vitamin D is associated with reduced risk of surgery in Crohn's disease. Inflamm Bowel Dis. 2013 Aug; 19(9):1921-7. PMID: 23751398.
    Citations: 75     Fields:    Translation:Humans
  21. Ananthakrishnan AN, Cai T, Savova G, Cheng SC, Chen P, Perez RG, Gainer VS, Murphy SN, Szolovits P, Xia Z, Shaw S, Churchill S, Karlson EW, Kohane I, Plenge RM, Liao KP. Improving case definition of Crohn's disease and ulcerative colitis in electronic medical records using natural language processing: a novel informatics approach. Inflamm Bowel Dis. 2013 Jun; 19(7):1411-20. PMID: 23567779.
    Citations: 59     Fields:    Translation:Humans
  22. Ananthakrishnan AN, Gainer VS, Cai T, Perez RG, Cheng SC, Savova G, Chen P, Szolovits P, Xia Z, De Jager PL, Shaw S, Churchill S, Karlson EW, Kohane I, Perlis RH, Plenge RM, Murphy SN, Liao KP. Similar risk of depression and anxiety following surgery or hospitalization for Crohn's disease and ulcerative colitis. Am J Gastroenterol. 2013 Apr; 108(4):594-601. PMID: 23337479.
    Citations: 21     Fields:    Translation:Humans
  23. Ananthakrishnan AN, Gainer VS, Perez RG, Cai T, Cheng SC, Savova G, Chen P, Szolovits P, Xia Z, De Jager PL, Shaw SY, Churchill S, Karlson EW, Kohane I, Perlis RH, Plenge RM, Murphy SN, Liao KP. Psychiatric co-morbidity is associated with increased risk of surgery in Crohn's disease. Aliment Pharmacol Ther. 2013 Feb; 37(4):445-54. PMID: 23289600.
    Citations: 36     Fields:    Translation:Humans
  24. Walcott BP, Edlow BL, Xia Z, Kahle KT, Nahed BV, Schmahmann JD. Steroid responsive A3243G mutation MELAS: clinical and radiographic evidence for regional hyperperfusion leading to neuronal loss. Neurologist. 2012 May; 18(3):159-70. PMID: 22549360.
    Citations: 5     Fields:    Translation:Humans
  25. Xia Z, Liu Q, Berger CT, Keenan BT, Kaliszewska A, Cheney PC, Srivastava GP, Castillo IW, De Jager PL, Alter G. A 17q12 allele is associated with altered NK cell subsets and function. J Immunol. 2012 Apr 01; 188(7):3315-22. PMID: 22345646.
    Citations: 7     Fields:    Translation:HumansCells
  26. Xia Z, Chibnik LB, Glanz BI, Liguori M, Shulman JM, Tran D, Khoury SJ, Chitnis T, Holyoak T, Weiner HL, Guttmann CR, De Jager PL. A putative Alzheimer's disease risk allele in PCK1 influences brain atrophy in multiple sclerosis. PLoS One. 2010 Nov 30; 5(11):e14169. PMID: 21152065.
    Citations: 10     Fields:    Translation:Humans
  27. Xia Z, Chen-Plotkin A, Schmahmann JD. Hypertrophic pachymeningitis and cerebral venous sinus thrombosis in inflammatory bowel disease. J Clin Neurosci. 2010 Nov; 17(11):1454-6. PMID: 20727771.
    Citations: 4     Fields:    Translation:Humans
  28. Xia Z, Mehta BP, Ropper AH, Kesari S. Paraneoplastic limbic encephalitis presenting as a neurological emergency: a case report. J Med Case Rep. 2010 Mar 24; 4:95. PMID: 20334684.
    Citations: 3     Fields:    
  29. Westover MB and Xia Z. Pocket Neurology (DM Greer, MB Westover, E Choi, K Awad, eds.). Meningitis, encephalitis, and brain abscess. 2010; 136-149.
  30. Parker SR, Dyson S, Brisman S, Pennie M, Swerlick RA, Khan R, Manos S, Korman BD, Xia Z, Korman NJ. Mortality of bullous pemphigoid: an evaluation of 223 patients and comparison with the mortality in the general population in the United States. J Am Acad Dermatol. 2008 Oct; 59(4):582-8. PMID: 18707800.
    Citations: 11     Fields:    Translation:Humans
  31. Opoka RO, Xia Z, Bangirana P, John CC. Inpatient mortality in children with clinically diagnosed malaria as compared with microscopically confirmed malaria. Pediatr Infect Dis J. 2008 Apr; 27(4):319-24. PMID: 18316995.
    Citations: 23     Fields:    Translation:HumansAnimals
  32. Xia Z and Roth BL. In: The medical basis of psychiatry (SH Fatemi and PJ Clayton, eds). Novel mechanisms of drug treatment in psychiatry. 2008; 519-534.
  33. Xia Z and Roth BL . The serotonin receptors – from molecular pharmacology to human therapeutics (Roth BL, ed). 5-HT receptor accessory proteins (FRAPs): relevance for targeting, trafficking and signal transduction. 2006; 257-276.
  34. Roth BL, Xia Z. Molecular and cellular mechanisms for the polarized sorting of serotonin receptors: relevance for genesis and treatment of psychosis. Crit Rev Neurobiol. 2004; 16(4):229-36. PMID: 15862107.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  35. Xia Z, Gray JA, Compton-Toth BA, Roth BL. A direct interaction of PSD-95 with 5-HT2A serotonin receptors regulates receptor trafficking and signal transduction. J Biol Chem. 2003 Jun 13; 278(24):21901-8. PMID: 12682061.
    Citations: 50     Fields:    Translation:HumansCells
  36. Xia Z, Hufeisen SJ, Gray JA, Roth BL. The PDZ-binding domain is essential for the dendritic targeting of 5-HT2A serotonin receptors in cortical pyramidal neurons in vitro. Neuroscience. 2003; 122(4):907-20. PMID: 14643760.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  37. Xia Z and Roth BL. In: Encyclopedia of Neuroscience, 3rd Edition (Adelman G, Smith BH, eds). Serotonin (5-hydroxytryptamine) receptor subtypes: from genes to behavior. 2003.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.