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profileZongqi Xia, M.D.,Ph.D.

TitleVisiting Scientist in Neurology
InstitutionBrigham and Women's Hospital
DepartmentNeurology
AddressHarvard Institutes of Medicine
BWH/Neurology - NRB255C
77 Avenue Louis Pasteur
Boston MA 02115
Phone617/525-4466
Fax617/525-5333
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Collapse Research 
Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R01NS098023     (XIA, ZONGQI)Sep 30, 2016 - Jun 30, 2021
NIH/NINDS
Integrating EHR and Genomics to Predict Multiple Sclerosis Drug Response
Role: Principal Investigator

K08NS079493     (XIA, ZONGQI)May 1, 2012 - Apr 30, 2017
NIH/NINDS
Leveraging genetics and environment to predict presymptomatic multiple sclerosis
Role: Principal Investigator

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Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Xia Z, Steele SU, Bakshi A, Clarkson SR, White CC, Schindler MK, Nair G, Dewey BE, Price LR, Ohayon J, Chibnik LB, Cortese IC, De Jager PL, Reich DS. Assessment of Early Evidence of Multiple Sclerosis in a Prospective Study of Asymptomatic High-Risk Family Members. JAMA Neurol. 2017 Mar 01; 74(3):293-300. PMID: 28114441.
    View in: PubMed
  2. Bargiela D, Bianchi MT, Westover MB, Chibnik LB, Healy BC, De Jager PL, Xia Z. Selection of first-line therapy in multiple sclerosis using risk-benefit decision analysis. Neurology. 2017 Feb 14; 88(7):677-684. PMID: 28087821.
    View in: PubMed
  3. Bove R, Chua AS, Xia Z, Chibnik L, De Jager PL, Chitnis T. Complex relation of HLA-DRB1*1501, age at menarche, and age at multiple sclerosis onset. Neurol Genet. 2016 Aug; 2(4):e88. PMID: 27504495; PMCID: PMC4962522.
  4. Xia Z, White CC, Owen EK, Von Korff A, Clarkson SR, McCabe CA, Cimpean M, Winn PA, Hoesing A, Steele SU, Cortese IC, Chitnis T, Weiner HL, Reich DS, Chibnik LB, De Jager PL. Genes and Environment in Multiple Sclerosis project: A platform to investigate multiple sclerosis risk. Ann Neurol. 2016 Feb; 79(2):178-89. PMID: 26583565; PMCID: PMC4778957 [Available on 02/01/17].
  5. Liao KP, Ananthakrishnan AN, Kumar V, Xia Z, Cagan A, Gainer VS, Goryachev S, Chen P, Savova GK, Agniel D, Churchill S, Lee J, Murphy SN, Plenge RM, Szolovits P, Kohane I, Shaw SY, Karlson EW, Cai T. Methods to Develop an Electronic Medical Record Phenotype Algorithm to Compare the Risk of Coronary Artery Disease across 3 Chronic Disease Cohorts. PLoS One. 2015; 10(8):e0136651. PMID: 26301417; PMCID: PMC4547801.
  6. Liao KP, Cai T, Savova GK, Murphy SN, Karlson EW, Ananthakrishnan AN, Gainer VS, Shaw SY, Xia Z, Szolovits P, Churchill S, Kohane I. Development of phenotype algorithms using electronic medical records and incorporating natural language processing. BMJ. 2015 Apr 24; 350:h1885. PMID: 25911572; PMCID: PMC4707569.
  7. Xia Z, Secor E, Chibnik LB, Bove RM, Cheng S, Chitnis T, Cagan A, Gainer VS, Chen PJ, Liao KP, Shaw SY, Ananthakrishnan AN, Szolovits P, Weiner HL, Karlson EW, Murphy SN, Savova GK, Cai T, Churchill SE, Plenge RM, Kohane IS, De Jager PL. Modeling disease severity in multiple sclerosis using electronic health records. PLoS One. 2013; 8(11):e78927. PMID: 24244385; PMCID: PMC3823928.
  8. Ottoboni L, Frohlich IY, Lee M, Healy BC, Keenan BT, Xia Z, Chitnis T, Guttmann CR, Khoury SJ, Weiner HL, Hafler DA, De Jager PL. Clinical relevance and functional consequences of the TNFRSF1A multiple sclerosis locus. Neurology. 2013 Nov 26; 81(22):1891-9. PMID: 24174586; PMCID: PMC3843384.
  9. Ananthakrishnan AN, Cagan A, Gainer VS, Cai T, Cheng SC, Savova G, Chen P, Szolovits P, Xia Z, De Jager PL, Shaw SY, Churchill S, Karlson EW, Kohane I, Plenge RM, Murphy SN, Liao KP. Normalization of plasma 25-hydroxy vitamin D is associated with reduced risk of surgery in Crohn's disease. Inflamm Bowel Dis. 2013 Aug; 19(9):1921-7. PMID: 23751398; PMCID: PMC3720838.
  10. Ananthakrishnan AN, Cai T, Savova G, Cheng SC, Chen P, Perez RG, Gainer VS, Murphy SN, Szolovits P, Xia Z, Shaw S, Churchill S, Karlson EW, Kohane I, Plenge RM, Liao KP. Improving case definition of Crohn's disease and ulcerative colitis in electronic medical records using natural language processing: a novel informatics approach. Inflamm Bowel Dis. 2013 Jun; 19(7):1411-20. PMID: 23567779; PMCID: PMC3665760.
  11. Ananthakrishnan AN, Gainer VS, Cai T, Perez RG, Cheng SC, Savova G, Chen P, Szolovits P, Xia Z, De Jager PL, Shaw S, Churchill S, Karlson EW, Kohane I, Perlis RH, Plenge RM, Murphy SN, Liao KP. Similar risk of depression and anxiety following surgery or hospitalization for Crohn's disease and ulcerative colitis. Am J Gastroenterol. 2013 Apr; 108(4):594-601. PMID: 23337479; PMCID: PMC3627544.
  12. Ananthakrishnan AN, Gainer VS, Perez RG, Cai T, Cheng SC, Savova G, Chen P, Szolovits P, Xia Z, De Jager PL, Shaw SY, Churchill S, Karlson EW, Kohane I, Perlis RH, Plenge RM, Murphy SN, Liao KP. Psychiatric co-morbidity is associated with increased risk of surgery in Crohn's disease. Aliment Pharmacol Ther. 2013 Feb; 37(4):445-54. PMID: 23289600; PMCID: PMC3552092.
  13. Walcott BP, Edlow BL, Xia Z, Kahle KT, Nahed BV, Schmahmann JD. Steroid responsive A3243G mutation MELAS: clinical and radiographic evidence for regional hyperperfusion leading to neuronal loss. Neurologist. 2012 May; 18(3):159-70. PMID: 22549360.
    View in: PubMed
  14. Xia Z, Liu Q, Berger CT, Keenan BT, Kaliszewska A, Cheney PC, Srivastava GP, Castillo IW, De Jager PL, Alter G. A 17q12 allele is associated with altered NK cell subsets and function. J Immunol. 2012 Apr 01; 188(7):3315-22. PMID: 22345646.
    View in: PubMed
  15. Xia Z, Chibnik LB, Glanz BI, Liguori M, Shulman JM, Tran D, Khoury SJ, Chitnis T, Holyoak T, Weiner HL, Guttmann CR, De Jager PL. A putative Alzheimer's disease risk allele in PCK1 influences brain atrophy in multiple sclerosis. PLoS One. 2010 Nov 30; 5(11):e14169. PMID: 21152065; PMCID: PMC2994939.
  16. Xia Z, Chen-Plotkin A, Schmahmann JD. Hypertrophic pachymeningitis and cerebral venous sinus thrombosis in inflammatory bowel disease. J Clin Neurosci. 2010 Nov; 17(11):1454-6. PMID: 20727771; PMCID: PMC2946484.
  17. Xia Z, Mehta BP, Ropper AH, Kesari S. Paraneoplastic limbic encephalitis presenting as a neurological emergency: a case report. J Med Case Rep. 2010 Mar 24; 4:95. PMID: 20334684; PMCID: PMC2860358.
  18. Westover MB and Xia Z. Pocket Neurology (DM Greer, MB Westover, E Choi, K Awad, eds.). Meningitis, encephalitis, and brain abscess. 2010; 136-149.
  19. Parker SR, Dyson S, Brisman S, Pennie M, Swerlick RA, Khan R, Manos S, Korman BD, Xia Z, Korman NJ. Mortality of bullous pemphigoid: an evaluation of 223 patients and comparison with the mortality in the general population in the United States. J Am Acad Dermatol. 2008 Oct; 59(4):582-8. PMID: 18707800.
    View in: PubMed
  20. Opoka RO, Xia Z, Bangirana P, John CC. Inpatient mortality in children with clinically diagnosed malaria as compared with microscopically confirmed malaria. Pediatr Infect Dis J. 2008 Apr; 27(4):319-24. PMID: 18316995; PMCID: PMC2607243.
  21. Xia Z and Roth BL. In: The medical basis of psychiatry (SH Fatemi and PJ Clayton, eds). Novel mechanisms of drug treatment in psychiatry. 2008; 519-534.
  22. Xia Z and Roth BL . The serotonin receptors – from molecular pharmacology to human therapeutics (Roth BL, ed). 5-HT receptor accessory proteins (FRAPs): relevance for targeting, trafficking and signal transduction. 2006; 257-276.
  23. Roth BL, Xia Z. Molecular and cellular mechanisms for the polarized sorting of serotonin receptors: relevance for genesis and treatment of psychosis. Crit Rev Neurobiol. 2004; 16(4):229-36. PMID: 15862107.
    View in: PubMed
  24. Xia Z, Gray JA, Compton-Toth BA, Roth BL. A direct interaction of PSD-95 with 5-HT2A serotonin receptors regulates receptor trafficking and signal transduction. J Biol Chem. 2003 Jun 13; 278(24):21901-8. PMID: 12682061.
    View in: PubMed
  25. Xia Z, Hufeisen SJ, Gray JA, Roth BL. The PDZ-binding domain is essential for the dendritic targeting of 5-HT2A serotonin receptors in cortical pyramidal neurons in vitro. Neuroscience. 2003; 122(4):907-20. PMID: 14643760.
    View in: PubMed
  26. Xia Z and Roth BL. In: Encyclopedia of Neuroscience, 3rd Edition (Adelman G, Smith BH, eds). Serotonin (5-hydroxytryptamine) receptor subtypes: from genes to behavior. 2003.
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