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Silke Nuber, Ph.D.

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current student opportunities
Available: 05/01/25, Expires: 05/01/27

The goal of the project is to define differences between sex or genotypes in mouse models of Parkinson's disease. Our group constantly tests (behavior, biochemistry, immunohistology) and applies novel treatments to Parkinson's disease mice. Therefore mice and/or tissue are available for the study. The role of the student is to design and conduct experiments that help to dissect mutant alpha-synuclein or mutant GBA1 induced brain pathologies of our model mice. Potential targets are: lysosomal markers/autophagy, estrogen-related pathways, differences in lipid-modulating enzymatic activities or neuroinflammation. The PI and her group have longterm previous experience with the mouse models and techniques for analyses.


Research
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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. RF1NS109510 (NUBER, SILKE) May 15, 2019 - Jun 30, 2027
    NIH
    Biologically Novel Mouse Models of PD with Progressive Synucleinopathy and Early-Onset Tremor and Motor Deficits Responsive to L-DOPA
    Role: Principal Investigator
  2. R01NS109510 (NUBER, SILKE) May 15, 2019 - Mar 31, 2024
    NIH
    Biologically novel mouse models of PD with progressive synucleinopathy and early-onset tremor and motor deficits responsive to L-DOPA
    Role: Principal Investigator
  3. R21NS103123 (NUBER, SILKE) Aug 15, 2017 - Jul 31, 2019
    NIH
    Shifting Multimers: New mouse and culture models of ?-synuclein truncation by calpain in PD
    Role: Principal Investigator

Bibliographic
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© 2025 President and Fellows of Harvard College
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.