Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Silke Nuber, Ph.D.

Title
Institution
Department
Address

Mentoring
current student opportunities
Available: 05/01/25, Expires: 05/01/27

The goal of the project is to define differences between sex or genotypes in mouse models of Parkinson's disease. Our group constantly tests (behavior, biochemistry, immunohistology) and applies novel treatments to Parkinson's disease mice. Therefore mice and/or tissue are available for the study. The role of the student is to design and conduct experiments that help to dissect mutant alpha-synuclein or mutant GBA1 induced brain pathologies of our model mice. Potential targets are: lysosomal markers/autophagy, estrogen-related pathways, differences in lipid-modulating enzymatic activities or neuroinflammation. The PI and her group have longterm previous experience with the mouse models and techniques for analyses.


Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
Most Recent  |  List All
  1. RF1NS109510 (NUBER, SILKE) May 15, 2019 - Jun 30, 2027
    NIH
    Biologically Novel Mouse Models of PD with Progressive Synucleinopathy and Early-Onset Tremor and Motor Deficits Responsive to L-DOPA
    Role: Principal Investigator
  2. R01NS109510 (NUBER, SILKE) May 15, 2019 - Mar 31, 2024
    NIH
    Biologically novel mouse models of PD with progressive synucleinopathy and early-onset tremor and motor deficits responsive to L-DOPA
    Role: Principal Investigator
  3. R21NS103123 (NUBER, SILKE) Aug 15, 2017 - Jul 31, 2019
    NIH
    Shifting Multimers: New mouse and culture models of ?-synuclein truncation by calpain in PD
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
Displaying 25 of 44 total Publications Show all
  1. Bolsinger MM, Moors TE, Brontesi L, Nuber S, Dettmer U, Ramalingam N. Acute lipid droplet accumulation induced by the inhibition of the phospholipase DDHD2 does not affect the level, solubility, or phosphoserine-129 status of a-synuclein. Metab Brain Dis. 2025 Jan 24; 40(1):111. PMID: 39853540.
    Citations:
    Fields: BraBrainMetMetabolism
  2. Adom MA, Hahn WN, McCaffery TD, Moors TE, Zhang X, Svenningsson P, Selkoe DJ, Fanning S, Nuber S. Reducing the lipase LIPE in mutant a-synuclein mice improves Parkinson-like deficits and reveals sex differences in fatty acid metabolism. Neurobiol Dis. 2024 Sep; 199:106593. PMID: 38971480; PMCID: PMC11577057.
    Citations: 1
    Fields: NeuNeurologyTranslation:Animals
  3. Nuber S, Zhang X, McCaffery TD, Moors TE, Adom MA, Hahn WN, Martin D, Ericsson M, Tripathi A, Dettmer U, Svenningsson P, Selkoe DJ. Author Correction: Generation of G51D and 3D mice reveals decreased a-synuclein tetramer-monomer ratios promote Parkinson's disease phenotypes. NPJ Parkinsons Dis. 2024 Mar 12; 10(1):57. PMID: 38472218; PMCID: PMC10933396.
    Citations:
  4. Nuber S, Zhang X, McCaffery TD, Moors TE, Adom MA, Hahn WN, Martin D, Ericsson M, Tripathi A, Dettmer U, Svenningsson P, Selkoe DJ. Generation of G51D and 3D mice reveals decreased a-synuclein tetramer-monomer ratios promote Parkinson's disease phenotypes. NPJ Parkinsons Dis. 2024 Feb 29; 10(1):47. PMID: 38424059; PMCID: PMC10904737.
    Citations: 4
  5. Moors TE, Li S, McCaffery TD, Ho GPH, Bechade PA, Pham LN, Ericsson M, Nuber S. Increased palmitoylation improves estrogen receptor alpha-dependent hippocampal synaptic deficits in a mouse model of synucleinopathy. Sci Adv. 2023 11 15; 9(46):eadj1454. PMID: 37976363; PMCID: PMC10957154.
    Citations: 3
    Fields: SciScienceTranslation:HumansAnimalsCells
  6. Nuber S, Selkoe DJ. The Parkinson-Associated Toxin Paraquat Shifts Physiological a-Synuclein Tetramers toward Monomers That Can Be Calpain-Truncated and Form Oligomers. Am J Pathol. 2023 05; 193(5):520-531. PMID: 36773784; PMCID: PMC10155269.
    Citations: 4
    Fields: PatPathologyTranslation:HumansAnimals
  7. Ramalingam N, Jin SX, Moors TE, Fonseca-Ornelas L, Shimanaka K, Lei S, Cam HP, Watson AH, Brontesi L, Ding L, Hacibaloglu DY, Jiang H, Choi SJ, Kanter E, Liu L, Bartels T, Nuber S, Sulzer D, Mosharov EV, Chen WV, Li S, Selkoe DJ, Dettmer U. Dynamic physiological a-synuclein S129 phosphorylation is driven by neuronal activity. NPJ Parkinsons Dis. 2023 Jan 16; 9(1):4. PMID: 36646701; PMCID: PMC9842642.
    Citations: 29
  8. Nuber S, Chung CY, Tardiff DF, Bechade PA, McCaffery TD, Shimanaka K, Choi J, Chang B, Raja W, Neves E, Burke C, Jiang X, Xu P, Khurana V, Dettmer U, Fanning S, Rhodes KJ, Selkoe DJ, Scannevin RH. Correction to: A Brain-Penetrant Stearoyl-CoA Desaturase Inhibitor Reverses a-Synuclein Toxicity. Neurotherapeutics. 2022 Jul; 19(4):1434. PMID: 35792968; PMCID: PMC9587197.
    Citations:
    Fields: NeuNeurology
  9. Nuber S, Chung CY, Tardiff DF, Bechade PA, McCaffery TD, Shimanaka K, Choi J, Chang B, Raja W, Neves E, Burke C, Jiang X, Xu P, Khurana V, Dettmer U, Fanning S, Rhodes KJ, Selkoe DJ, Scannevin RH. A Brain-Penetrant Stearoyl-CoA Desaturase Inhibitor Reverses a-Synuclein Toxicity. Neurotherapeutics. 2022 04; 19(3):1018-1036. PMID: 35445353; PMCID: PMC9294123.
    Citations: 7
    Fields: NeuNeurologyTranslation:HumansAnimalsCells
  10. Tripathi A, Alnakhala H, Terry-Kantor E, Newman A, Liu L, Imberdis T, Fanning S, Nuber S, Ramalingam N, Selkoe D, Dettmer U. Pathogenic Mechanisms of Cytosolic and Membrane-Enriched a-Synuclein Converge on Fatty Acid Homeostasis. J Neurosci. 2022 03 09; 42(10):2116-2130. PMID: 35086904; PMCID: PMC8916762.
    Citations: 11
    Fields: NeuNeurologyTranslation:AnimalsCells
  11. Glajch KE, Moors TE, Chen Y, Bechade PA, Nam AY, Rajsombath MM, McCaffery TD, Dettmer U, Weihofen A, Hirst WD, Selkoe DJ, Nuber S. Wild-type GBA1 increases the a-synuclein tetramer-monomer ratio, reduces lipid-rich aggregates, and attenuates motor and cognitive deficits in mice. Proc Natl Acad Sci U S A. 2021 08 03; 118(31). PMID: 34326260; PMCID: PMC8346893.
    Citations: 16
    Fields: SciScienceTranslation:Animals
  12. Fonseca-Ornelas L, Viennet T, Rovere M, Jiang H, Liu L, Nuber S, Ericsson M, Arthanari H, Selkoe DJ. Altered conformation of a-synuclein drives dysfunction of synaptic vesicles in a synaptosomal model of Parkinson's disease. Cell Rep. 2021 07 06; 36(1):109333. PMID: 34233191; PMCID: PMC8552450.
    Citations: 16
    Fields: CelCell BiologyMolMolecular BiologyTranslation:HumansAnimalsCells
  13. Nuber S, Nam AY, Rajsombath MM, Cirka H, Hronowski X, Wang J, Hodgetts K, Kalinichenko LS, Müller CP, Lambrecht V, Winkler J, Weihofen A, Imberdis T, Dettmer U, Fanning S, Selkoe DJ. A Stearoyl-Coenzyme A Desaturase Inhibitor Prevents Multiple Parkinson Disease Phenotypes in a-Synuclein Mice. Ann Neurol. 2021 01; 89(1):74-90. PMID: 32996158.
    Citations: 32
    Fields: NeuNeurologyTranslation:HumansAnimalsCells
  14. Rajsombath MM, Nam AY, Ericsson M, Nuber S. Female Sex and Brain-Selective Estrogen Benefit a-Synuclein Tetramerization and the PD-like Motor Syndrome in 3K Transgenic Mice. J Neurosci. 2019 09 18; 39(38):7628-7640. PMID: 31405930; PMCID: PMC6750939.
    Citations: 23
    Fields: NeuNeurologyTranslation:Animals
  15. Fanning S, Haque A, Imberdis T, Baru V, Barrasa MI, Nuber S, Termine D, Ramalingam N, Ho GPH, Noble T, Sandoe J, Lou Y, Landgraf D, Freyzon Y, Newby G, Soldner F, Terry-Kantor E, Kim TE, Hofbauer HF, Becuwe M, Jaenisch R, Pincus D, Clish CB, Walther TC, Farese RV, Srinivasan S, Welte MA, Kohlwein SD, Dettmer U, Lindquist S, Selkoe D. Lipidomic Analysis of a-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment. Mol Cell. 2019 03 07; 73(5):1001-1014.e8. PMID: 30527540; PMCID: PMC6408259.
    Citations: 133
    Fields: CelCell BiologyMolMolecular BiologyTranslation:HumansAnimalsCells
  16. Nuber S, Rajsombath M, Minakaki G, Winkler J, Müller CP, Ericsson M, Caldarone B, Dettmer U, Selkoe DJ. Abrogating Native a-Synuclein Tetramers in Mice Causes a L-DOPA-Responsive Motor Syndrome Closely Resembling Parkinson's Disease. Neuron. 2018 10 10; 100(1):75-90.e5. PMID: 30308173; PMCID: PMC6211795.
    Citations: 78
    Fields: NeuNeurologyTranslation:AnimalsCells
  17. Dettmer U, Ramalingam N, von Saucken VE, Kim TE, Newman AJ, Terry-Kantor E, Nuber S, Ericsson M, Fanning S, Bartels T, Lindquist S, Levy OA, Selkoe D. Loss of native a-synuclein multimerization by strategically mutating its amphipathic helix causes abnormal vesicle interactions in neuronal cells. Hum Mol Genet. 2017 09 15; 26(18):3466-3481. PMID: 28911198; PMCID: PMC5884392.
    Citations: 59
    Fields: GenGenetics, MedicalMolMolecular BiologyTranslation:HumansAnimalsCells
  18. Casadei N, Sood P, Ulrich T, Fallier-Becker P, Kieper N, Helling S, May C, Glaab E, Chen J, Nuber S, Wolburg H, Marcus K, Rapaport D, Ott T, Riess O, Krüger R, Fitzgerald JC. Mitochondrial defects and neurodegeneration in mice overexpressing wild-type or G399S mutant HtrA2. Hum Mol Genet. 2016 12 15; 25(24):5513. PMID: 28031291.
    Citations: 2
    Fields: GenGenetics, MedicalMolMolecular Biology
  19. Nuber S, Selkoe DJ. Caspase-1 clipping causes complications for a-synuclein. Proc Natl Acad Sci U S A. 2016 Sep 06; 113(36):9958-60. PMID: 27551083; PMCID: PMC5018740.
    Citations: 6
    Fields: SciScienceTranslation:HumansCells
  20. Casadei N, Sood P, Ulrich T, Fallier-Becker P, Kieper N, Helling S, May C, Glaab E, Chen J, Nuber S, Wolburg H, Marcus K, Rapaport D, Ott T, Riess O, Krüger R, Fitzgerald JC. Mitochondrial defects and neurodegeneration in mice overexpressing wild-type or G399S mutant HtrA2. Hum Mol Genet. 2016 02 01; 25(3):459-71. PMID: 26604148.
    Citations: 9
    Fields: GenGenetics, MedicalMolMolecular BiologyTranslation:HumansAnimalsCells
  21. Kohl Z, Ben Abdallah N, Vogelgsang J, Tischer L, Deusser J, Amato D, Anderson S, Müller CP, Riess O, Masliah E, Nuber S, Winkler J. Severely impaired hippocampal neurogenesis associates with an early serotonergic deficit in a BAC a-synuclein transgenic rat model of Parkinson's disease. Neurobiol Dis. 2016 Jan; 85:206-217. PMID: 26523794; PMCID: PMC4974940.
    Citations: 42
    Fields: NeuNeurologyTranslation:HumansAnimalsCells
  22. Schlachetzki JC, Grimm T, Schlachetzki Z, Ben Abdallah NM, Ettle B, Vöhringer P, Ferger B, Winner B, Nuber S, Winkler J. Dopaminergic lesioning impairs adult hippocampal neurogenesis by distinct modification of a-synuclein. J Neurosci Res. 2016 Jan; 94(1):62-73. PMID: 26451750.
    Citations: 12
    Fields: NeuNeurologyTranslation:Animals
  23. Van der Perren A, Toelen J, Casteels C, Macchi F, Van Rompuy AS, Sarre S, Casadei N, Nuber S, Himmelreich U, Osorio Garcia MI, Michotte Y, D'Hooge R, Bormans G, Van Laere K, Gijsbers R, Van den Haute C, Debyser Z, Baekelandt V. Longitudinal follow-up and characterization of a robust rat model for Parkinson's disease based on overexpression of alpha-synuclein with adeno-associated viral vectors. Neurobiol Aging. 2015 Mar; 36(3):1543-58. PMID: 25599874.
    Citations: 42
    Fields: GerGeriatricsNeuNeurologyPhyPhysiologyTranslation:AnimalsCells
  24. Games D, Valera E, Spencer B, Rockenstein E, Mante M, Adame A, Patrick C, Ubhi K, Nuber S, Sacayon P, Zago W, Seubert P, Barbour R, Schenk D, Masliah E. Reducing C-terminal-truncated alpha-synuclein by immunotherapy attenuates neurodegeneration and propagation in Parkinson's disease-like models. J Neurosci. 2014 Jul 09; 34(28):9441-54. PMID: 25009275.
    Citations: 165
    Fields: NeuNeurologyTranslation:HumansAnimals
  25. Rockenstein E, Nuber S, Overk CR, Ubhi K, Mante M, Patrick C, Adame A, Trejo-Morales M, Gerez J, Picotti P, Jensen PH, Campioni S, Riek R, Winkler J, Gage FH, Winner B, Masliah E. Accumulation of oligomer-prone a-synuclein exacerbates synaptic and neuronal degeneration in vivo. Brain. 2014 May; 137(Pt 5):1496-513. PMID: 24662516; PMCID: PMC3999721.
    Citations: 114
    Fields: BraBrainNeuNeurologyTranslation:HumansAnimalsCells
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact contact@catalyst.harvard.edu. For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at human_resources@hms.harvard.edu. For faculty personal and demographic information, contact HMS Office for Faculty Affairs at facappt@hms.harvard.edu.
Nuber's Networks
Click the
Explore
buttons for more information and interactive visualizations!
Concepts (215)
Explore
_
Co-Authors (19)
Explore
_
Similar People (60)
Explore
_
Same Department 
Explore
© 2025 President and Fellows of Harvard College
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.