Silke Nuber | Harvard Catalyst Profiles

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Silke Nuber, Ph.D.

Title

Associate Professor of Neurology

Institution

Brigham and Women's Hospital

Department

Neurology

Address

Harvard Divinity School
Andover Hall
45 Francis Ave
Cambridge MA 02138

current student opportunities|

research activities and funding|

selected publications|

Mentoring

current student opportunities

Characterizing mouse models for Parkinson's disease [login at prompt]

Available: 05/01/25, Expires: 05/01/27

The goal of the project is to define differences between sex or genotypes in mouse models of Parkinson's disease. Our group constantly tests (behavior, biochemistry, immunohistology) and applies novel treatments to Parkinson's disease mice. Therefore mice and/or tissue are available for the study. The role of the student is to design and conduct experiments that help to dissect mutant alpha-synuclein or mutant GBA1 induced brain pathologies of our model mice. Potential targets are: lysosomal markers/autophagy, estrogen-related pathways, differences in lipid-modulating enzymatic activities or neuroinflammation. The PI and her group have longterm previous experience with the mouse models and techniques for analyses.

Research

research activities and funding

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.

Most Recent | List All

RF1NS109510 (NUBER, SILKE) May 15, 2019 - Jun 30, 2027

NIH

Biologically Novel Mouse Models of PD with Progressive Synucleinopathy and Early-Onset Tremor and Motor Deficits Responsive to L-DOPA

Role: Principal Investigator
R01NS109510 (NUBER, SILKE) May 15, 2019 - Mar 31, 2024

NIH

Biologically novel mouse models of PD with progressive synucleinopathy and early-onset tremor and motor deficits responsive to L-DOPA

Role: Principal Investigator
R21NS103123 (NUBER, SILKE) Aug 15, 2017 - Jul 31, 2019

NIH

Shifting Multimers: New mouse and culture models of ?-synuclein truncation by calpain in PD

Role: Principal Investigator

Bibliographic

selected publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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