Harvard Catalyst Profiles

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Vikram Khurana, Ph.D., M.B.,B.S.

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Biography
2001 - 2006
Fulbright Postgraduate Award
2004 - 2005
Merck Company Foundation Fellowship
2011 - 2014
American Brain and Parkinson's Disease Foundations Clinician-Scientist Development Award
2016 - 2017
Young Investigator Award
2018
Bishop Dr. Karl Golser Award for Research in Atypical Parkinsonian Disorders
2018 - 2020
Brigham Research Institute Director's Transformative Award
2019 - 2024
New York Stem Cell Foundation Robertson Stem Cell Investigator
2019 - 2022
George C. Cotzias Fellow

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Aboud Syriani D, Wong D, Andani S, De Gusmao CM, Mao Y, Sanyoura M, Glotzer G, Lockhart PJ, Hassin-Baer S, Khurana V, Gomez CM, Perlman S, Das S, Fogel BL. Prevalence of RFC1-mediated spinocerebellar ataxia in a North American ataxia cohort. Neurol Genet. 2020 Jun; 6(3):e440. PMID: 32582864.
    Citations:    
  2. Lam I, Hallacli E, Khurana V. Proteome-Scale Mapping of Perturbed Proteostasis in Living Cells. Cold Spring Harb Perspect Biol. 2020 Feb 03; 12(2). PMID: 30910772.
    Citations:    
  3. Carmona-Abellan M, Gabilondo I, Murueta-Goyena A, Khurana V, Tijero B, Luquin MR, Acera M, Del Pino R, Gardeazabal J, Martínez-Valbuena I, Sanchez-Pernaute R, Gómez-Esteban JC. Small fiber neuropathy and phosphorylated alpha-synuclein in the skin of E46K-SNCA mutation carriers. Parkinsonism Relat Disord. 2019 08; 65:139-145. PMID: 31178336.
    Citations:    
  4. Sanz R, Ovando-Roche P, Udeshi ND, Carr SA, Chung CY, Khurana V. In Situ Peroxidase Labeling and Mass Spectrometry of Alpha-Synuclein in Rat Cortical Neurons. Methods Mol Biol. 2019; 1948:235-246. PMID: 30771182.
    Citations:    
  5. Vincent BM, Tardiff DF, Piotrowski JS, Aron R, Lucas MC, Chung CY, Bacherman H, Chen Y, Pires M, Subramaniam R, Doshi DB, Sadlish H, Raja WK, Solís EJ, Khurana V, Le Bourdonnec B, Scannevin RH, Rhodes KJ. Inhibiting Stearoyl-CoA Desaturase Ameliorates a-Synuclein Cytotoxicity. Cell Rep. 2018 12 04; 25(10):2742-2754.e31. PMID: 30517862.
    Citations:    Fields:    
  6. Walsh RR, Krismer F, Galpern WR, Wenning GK, Low PA, Halliday G, Koroshetz WJ, Holton J, Quinn NP, Rascol O, Shaw LM, Eidelberg D, Bower P, Cummings JL, Abler V, Biedenharn J, Bitan G, Brooks DJ, Brundin P, Fernandez H, Fortier P, Freeman R, Gasser T, Hewitt A, Höglinger GU, Huentelman MJ, Jensen PH, Jeromin A, Kang UJ, Kaufmann H, Kellerman L, Khurana V, Klockgether T, Kim WS, Langer C, LeWitt P, Masliah E, Meissner W, Melki R, Ostrowitzki S, Piantadosi S, Poewe W, Robertson D, Roemer C, Schenk D, Schlossmacher M, Schmahmann JD, Seppi K, Shih L, Siderowf A, Stebbins GT, Stefanova N, Tsuji S, Sutton S, Zhang J. Recommendations of the Global Multiple System Atrophy Research Roadmap Meeting. Neurology. 2018 01 09; 90(2):74-82. PMID: 29237794.
    Citations: 1     Fields:    
  7. Jarosz DF, Khurana V. Specification of Physiologic and Disease States by Distinct Proteins and Protein Conformations. Cell. 2017 Nov 16; 171(5):1001-1014. PMID: 29149602.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  8. Mittal S, Bjørnevik K, Im DS, Flierl A, Dong X, Locascio JJ, Abo KM, Long E, Jin M, Xu B, Xiang YK, Rochet JC, Engeland A, Rizzu P, Heutink P, Bartels T, Selkoe DJ, Caldarone BJ, Glicksman MA, Khurana V, Schüle B, Park DS, Riise T, Scherzer CR. ß2-Adrenoreceptor is a regulator of the a-synuclein gene driving risk of Parkinson's disease. Science. 2017 09 01; 357(6354):891-898. PMID: 28860381.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  9. Khurana V, Chung CY, Tardiff DF. From Yeast to Patients: The Audacity and Vision of Susan Lindquist. Cell Syst. 2017 02 22; 4(2):147-148. PMID: 28231447.
    Citations: 1     Fields:    
  10. Chung CY, Khurana V, Yi S, Sahni N, Loh KH, Auluck PK, Baru V, Udeshi ND, Freyzon Y, Carr SA, Hill DE, Vidal M, Ting AY, Lindquist S. In Situ Peroxidase Labeling and Mass-Spectrometry Connects Alpha-Synuclein Directly to Endocytic Trafficking and mRNA Metabolism in Neurons. Cell Syst. 2017 02 22; 4(2):242-250.e4. PMID: 28131823.
    Citations: 9     Fields:    
  11. Khurana V, Peng J, Chung CY, Auluck PK, Fanning S, Tardiff DF, Bartels T, Koeva M, Eichhorn SW, Benyamini H, Lou Y, Nutter-Upham A, Baru V, Freyzon Y, Tuncbag N, Costanzo M, San Luis BJ, Schöndorf DC, Barrasa MI, Ehsani S, Sanjana N, Zhong Q, Gasser T, Bartel DP, Vidal M, Deleidi M, Boone C, Fraenkel E, Berger B, Lindquist S. Genome-Scale Networks Link Neurodegenerative Disease Genes to a-Synuclein through Specific Molecular Pathways. Cell Syst. 2017 02 22; 4(2):157-170.e14. PMID: 28131822.
    Citations: 11     Fields:    
  12. Khurana V, Tardiff DF, Chung CY, Lindquist S. Toward stem cell-based phenotypic screens for neurodegenerative diseases. Nat Rev Neurol. 2015 Jun; 11(6):339-50. PMID: 25986505.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  13. Sahni N, Yi S, Taipale M, Fuxman Bass JI, Coulombe-Huntington J, Yang F, Peng J, Weile J, Karras GI, Wang Y, Kovács IA, Kamburov A, Krykbaeva I, Lam MH, Tucker G, Khurana V, Sharma A, Liu YY, Yachie N, Zhong Q, Shen Y, Palagi A, San-Miguel A, Fan C, Balcha D, Dricot A, Jordan DM, Walsh JM, Shah AA, Yang X, Stoyanova AK, Leighton A, Calderwood MA, Jacob Y, Cusick ME, Salehi-Ashtiani K, Whitesell LJ, Sunyaev S, Berger B, Barabási AL, Charloteaux B, Hill DE, Hao T, Roth FP, Xia Y, Walhout AJM, Lindquist S, Vidal M. Widespread macromolecular interaction perturbations in human genetic disorders. Cell. 2015 Apr 23; 161(3):647-660. PMID: 25910212.
    Citations: 76     Fields:    Translation:HumansCells
  14. Tardiff DF, Khurana V, Chung CY, Lindquist S. From yeast to patient neurons and back again: powerful new discovery platform. Mov Disord. 2014 Sep; 29(10):1231-40. PMID: 25131316.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  15. Chung CY*, Khurana V*, Auluck PK, Tardiff DF, Mazzulli JR, Soldner F, Baru V, Lou Y, Freyzon Y, Cho S, Mungenast AE, Muffat J, Mitalipova M, Pluth MD, Jui NT, Schüle B, Lippard SJ, Tsai LH, Krainc D, Buchwald SL, Jaenisch R, Lindquist S. Identification and Rescue of a-Synuclein Toxicity in Parkinson Patient-Derived Neurons. Science. 2013; *Equal contribution.
  16. Tardiff DF, Jui NT, Khurana V, Tambe MA, Thompson ML, Chung CY, Kamadurai HB, Kim HT, Lancaster AK, Caldwell KA, Caldwell GA, Rochet JC, Buchwald SL, Lindquist S. Yeast reveal a "druggable" Rsp5/Nedd4 network that ameliorates a-synuclein toxicity in neurons. Science. 2013 Nov 22; 342(6161):979-83. PMID: 24158909.
    Citations: 71     Fields:    Translation:AnimalsCells
  17. Ding H, Dhima K, Lockhart KC, Locascio JJ, Hoesing AN, Duong K, Trisini-Lipsanopoulos A, Hayes MT, Sohur US, Wills AM, Mollenhauer B, Flaherty AW, Hung AY, Mejia N, Khurana V, Gomperts SN, Selkoe DJ, Schwarzschild MA, Schlossmacher MG, Hyman BT, Sudarsky LR, Growdon JH, Scherzer CR. Unrecognized vitamin D3 deficiency is common in Parkinson disease: Harvard Biomarker Study. Neurology. 2013 Oct 22; 81(17):1531-7. PMID: 24068787.
    Citations: 22     Fields:    Translation:Humans
  18. Khurana V, Merlo P, DuBoff B, Fulga TA, Sharp KA, Campbell SD, Götz J, Feany MB. A neuroprotective role for the DNA damage checkpoint in tauopathy. Aging Cell. 2012 Apr; 11(2):360-2. PMID: 22181010.
    Citations: 12     Fields:    Translation:Animals
  19. Soldner F, Laganière J, Cheng AW, Hockemeyer D, Gao Q, Alagappan R, Khurana V, Golbe LI, Myers RH, Lindquist S, Zhang L, Guschin D, Fong LK, Vu BJ, Meng X, Urnov FD, Rebar EJ, Gregory PD, Zhang HS, Jaenisch R. Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations. Cell. 2011 Jul 22; 146(2):318-31. PMID: 21757228.
    Citations: 266     Fields:    Translation:HumansCells
  20. Vikram Khurana, Susanna B. Mierau and Bradford C. Dickerson. . Pocket Neurology (Greer DM, ed). Dementia. 2011.
  21. Khurana V, Elson-Schwab I, Fulga TA, Sharp KA, Loewen CA, Mulkearns E, Tyynelä J, Scherzer CR, Feany MB. Lysosomal dysfunction promotes cleavage and neurotoxicity of tau in vivo. PLoS Genet. 2010 Jul 15; 6(7):e1001026. PMID: 20664788.
    Citations: 33     Fields:    Translation:AnimalsCells
  22. Khurana V, Lindquist S. Modelling neurodegeneration in Saccharomyces cerevisiae: why cook with baker's yeast? Nat Rev Neurosci. 2010 06; 11(6):436-49. PMID: 20424620.
    Citations: 71     Fields:    Translation:HumansAnimals
  23. Khurana V. Modeling Tauopathy in the fruit fly Drosophila melanogaster. J Alzheimers Dis. 2008 Dec; 15(4):541-53. PMID: 19096155.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  24. Fulga TA, Elson-Schwab I, Khurana V, Steinhilb ML, Spires TL, Hyman BT, Feany MB. Abnormal bundling and accumulation of F-actin mediates tau-induced neuronal degeneration in vivo. Nat Cell Biol. 2007 Feb; 9(2):139-48. PMID: 17187063.
    Citations: 134     Fields:    Translation:HumansAnimalsCells
  25. Gavin BA, Dolph MJ, Deleault NR, Geoghegan JC, Khurana V, Feany MB, Dolph PJ, Supattapone S. Accelerated accumulation of misfolded prion protein and spongiform degeneration in a Drosophila model of Gerstmann-Sträussler-Scheinker syndrome. J Neurosci. 2006 Nov 29; 26(48):12408-14. PMID: 17135402.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  26. Khurana V, Feany MB. Connecting cell-cycle activation to neurodegeneration in Drosophila. Biochim Biophys Acta. 2007 Apr; 1772(4):446-56. PMID: 17141486.
    Citations: 11     Fields:    Translation:AnimalsCells
  27. Khurana V, Lu Y, Steinhilb ML, Oldham S, Shulman JM, Feany MB. TOR-mediated cell-cycle activation causes neurodegeneration in a Drosophila tauopathy model. Curr Biol. 2006 Feb 07; 16(3):230-41. PMID: 16461276.
    Citations: 96     Fields:    Translation:AnimalsCells
  28. Khurana V, Fulga TA, Feany MB. Senseless makes sense for spinocerebellar ataxia-1. Nat Neurosci. 2005 Nov; 8(11):1422-4. PMID: 16251977.
    Citations:    Fields:    Translation:HumansAnimalsCells
  29. Bütefisch CM, Khurana V, Kopylev L, Cohen LG. Enhancing encoding of a motor memory in the primary motor cortex by cortical stimulation. J Neurophysiol. 2004 May; 91(5):2110-6. PMID: 14711974.
    Citations: 53     Fields:    Translation:Humans
  30. Macleod GT, Khurana V, Gibson WG, Bennett MR. Probability of quantal secretion and the mobilization of vesicles at the active zones of endplates. J Theor Biol. 1998 Apr 07; 191(3):323-34. PMID: 9631571.
    Citations:    Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.