Harvard Catalyst Profiles

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Xiaoming Dai, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. K99CA259329 (DAI, XIAOMING) Mar 1, 2021 - Feb 28, 2023
    Elucidating a Novel Mechanism for LATS1/2 in Suppressing Tumorigenesis
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Jiang Q, Zhang X, Dai X, Han S, Wu X, Wang L, Wei W, Zhang N, Xie W, Guo J. S6K1-mediated phosphorylation of PDK1 impairs AKT kinase activity and oncogenic functions. Nat Commun. 2022 03 22; 13(1):1548. PMID: 35318320; PMCID: PMC8941131.
    Citations: 6     Fields:    Translation:HumansCells
  2. Liu L, Dai X, Yin S, Liu P, Hill EG, Wei W, Gan W. DNA-PK promotes activation of the survival kinase AKT in response to DNA damage through an mTORC2-ECT2 pathway. Sci Signal. 2022 01 04; 15(715):eabh2290. PMID: 34982576; PMCID: PMC8992387.
    Citations: 5     Fields:    Translation:Cells
  3. Guo J, Cheng J, Zheng N, Zhang X, Dai X, Zhang L, Hu C, Wu X, Jiang Q, Wu D, Okada H, Pandolfi PP, Wei W. Copper Promotes Tumorigenesis by Activating the PDK1-AKT Oncogenic Pathway in a Copper Transporter 1 Dependent Manner. Adv Sci (Weinh). 2021 09; 8(18):e2004303. PMID: 34278744.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  4. Dai X, Bu X, Gao Y, Guo J, Hu J, Jiang C, Zhang Z, Xu K, Duan J, He S, Zhang J, Wan L, Liu T, Zhou X, Hung MC, Freeman GJ, Wei W. Energy status dictates PD-L1 protein abundance and anti-tumor immunity to enable checkpoint blockade. Mol Cell. 2021 06 03; 81(11):2317-2331.e6. PMID: 33909988; PMCID: PMC8178223.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  5. Dai X, Gao Y, Wei W. Post-translational regulations of PD-L1 and PD-1: Mechanisms and opportunities for combined immunotherapy. Semin Cancer Biol. 2022 10; 85:246-252. PMID: 33831533; PMCID: PMC8490479.
    Citations: 3     Fields:    
  6. Gao Y, Nihira NT, Bu X, Chu C, Zhang J, Kolodziejczyk A, Fan Y, Chan NT, Ma L, Liu J, Wang D, Dai X, Liu H, Ono M, Nakanishi A, Inuzuka H, North BJ, Huang YH, Sharma S, Geng Y, Xu W, Liu XS, Li L, Miki Y, Sicinski P, Freeman GJ, Wei W. Acetylation-dependent regulation of PD-L1 nuclear translocation dictates the efficacy of anti-PD-1 immunotherapy. Nat Cell Biol. 2020 09; 22(9):1064-1075. PMID: 32839551; PMCID: PMC7484128.
    Citations: 48     Fields:    Translation:HumansAnimalsCells
  7. Dai X, Liu J, Wei W. DUB-independent regulation of pVHL by OTUD6B suppresses hepatocellular carcinoma. Protein Cell. 2020 08; 11(8):546-548. PMID: 32323143.
    Citations: 2     Fields:    Translation:Humans
  8. Wang P, Dai X, Jiang W, Li Y, Wei W. RBR E3 ubiquitin ligases in tumorigenesis. Semin Cancer Biol. 2020 Dec; 67(Pt 2):131-144. PMID: 32442483.
    Citations: 17     Fields:    Translation:Humans
  9. Wang Z, Song Y, Ye M, Dai X, Zhu X, Wei W. The diverse roles of SPOP in prostate cancer and kidney cancer. Nat Rev Urol. 2020 06; 17(6):339-350. PMID: 32355326.
    Citations: 21     Fields:    Translation:Humans
  10. Gan W, Dai X, Dai X, Xie J, Yin S, Zhu J, Wang C, Liu Y, Guo J, Wang M, Liu J, Hu J, Quinton RJ, Ganem NJ, Liu P, Asara JM, Pandolfi PP, Yang Y, He Z, Gao G, Wei W. LATS suppresses mTORC1 activity to directly coordinate Hippo and mTORC1 pathways in growth control. Nat Cell Biol. 2020 02; 22(2):246-256. PMID: 32015438; PMCID: PMC7076906.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  11. Liu H, Dai X, Cao X, Yan H, Ji X, Zhang H, Shen S, Si Y, Zhang H, Chen J, Li L, Zhao JC, Yu J, Feng XH, Zhao B. PRDM4 mediates YAP-induced cell invasion by activating leukocyte-specific integrin ß2 expression. EMBO Rep. 2018 06; 19(6). PMID: 29669796; PMCID: PMC5989780.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  12. Dai X, Liu H, Shen S, Guo X, Yan H, Ji X, Li L, Huang J, Feng XH, Zhao B. YAP activates the Hippo pathway in a negative feedback loop. Cell Res. 2017 08; 27(8):1073. PMID: 28761168; PMCID: PMC5539357.
    Citations: 5     Fields:    
  13. Si Y, Ji X, Cao X, Dai X, Xu L, Zhao H, Guo X, Yan H, Zhang H, Zhu C, Zhou Q, Tang M, Xia Z, Li L, Cong YS, Ye S, Liang T, Feng XH, Zhao B. Src Inhibits the Hippo Tumor Suppressor Pathway through Tyrosine Phosphorylation of Lats1. Cancer Res. 2017 09 15; 77(18):4868-4880. PMID: 28754671.
    Citations: 59     Fields:    Translation:HumansAnimalsCells
  14. Guo X, Zhao Y, Yan H, Yang Y, Shen S, Dai X, Ji X, Ji F, Gong XG, Li L, Bai X, Feng XH, Liang T, Ji J, Chen L, Wang H, Zhao B. Single tumor-initiating cells evade immune clearance by recruiting type II macrophages. Genes Dev. 2017 02 01; 31(3):247-259. PMID: 28223311; PMCID: PMC5358722.
    Citations: 84     Fields:    Translation:HumansAnimalsCells
  15. Dai X, Liu H, Shen S, Guo X, Yan H, Ji X, Li L, Huang J, Feng XH, Zhao B. YAP activates the Hippo pathway in a negative feedback loop. Cell Res. 2015 Oct; 25(10):1175-8. PMID: 26315483; PMCID: PMC4650621.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  16. Dai X, She P, Chi F, Feng Y, Liu H, Jin D, Zhao Y, Guo X, Jiang D, Guan KL, Zhong TP, Zhao B. Phosphorylation of angiomotin by Lats1/2 kinases inhibits F-actin binding, cell migration, and angiogenesis. J Biol Chem. 2013 Nov 22; 288(47):34041-34051. PMID: 24106267; PMCID: PMC3837143.
    Citations: 81     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.