Harvard Catalyst Profiles

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Xiaoming Dai, Ph.D.

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  1. R00CA259329 (XIAOMING DAI) Mar 1, 2023 - Feb 28, 2026
    NIH/NCI
    Elucidating a Novel Mechanism for LATS1/2 in Suppressing Tumorigenesis
    Role Description: Dysregulation of the tumor suppressors LATS1/2, core components of Hippo pathway, is common in many human tumors including breast cancer, but its upstream regulator and physiological role in breast tumorigenesis remains unclear. This proposal aims to elucidate how LATS1/2 kinase activity and tumor suppressive function is regulated by upstream deubiquitinase OTUD3, as well as to examine how LATS1/2 are critically involved in breast tumorigenesis through phosphorylating Raptor at Ser606, which in turn suppresses mTORC1 kinase activity.
    Role: PI
  2. K99CA259329 (DAI, XIAOMING) Mar 1, 2021 - Feb 28, 2023
    NIH
    Elucidating a Novel Mechanism for LATS1/2 in Suppressing Tumorigenesis
    Role: Principal Investigator

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Concepts (115)
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Co-Authors (23)
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.