Title Assistant Professor of Pathology Institution Beth Israel Deaconess Medical Center Address Beth Israel Deaconess Medical Center
330 Brookline Ave
Boston MA 02215
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Research
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R00CA259329
(XIAOMING DAI)
Mar 1, 2023 - Feb 28, 2026
Elucidating a Novel Mechanism for LATS1/2 in Suppressing Tumorigenesis
Role Description: Dysregulation of the tumor suppressors LATS1/2, core components of Hippo pathway, is common in many human tumors including breast cancer, but its upstream regulator and physiological role in breast tumorigenesis remains unclear. This proposal aims to elucidate how LATS1/2 kinase activity and tumor suppressive function is regulated by upstream deubiquitinase OTUD3, as well as to examine how LATS1/2 are critically involved in breast tumorigenesis through phosphorylating Raptor at Ser606, which in turn suppresses mTORC1 kinase activity.
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K99CA259329
(DAI, XIAOMING)
Mar 1, 2021 - Feb 28, 2023
Elucidating a Novel Mechanism for LATS1/2 in Suppressing Tumorigenesis
Role: Principal Investigator
Bibliographic
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