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profileSava Sakadzic, Ph.D.

TitleAssistant Professor of Radiology
InstitutionMassachusetts General Hospital
DepartmentRadiology
AddressMassachusetts General Hospital
Radiology, Rm. 2301
149 13th Street
Charlestown MA 02129
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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Boas DA, Sakadžic S, Selb J, Farzam P, Franceschini MA, Carp SA. Establishing the diffuse correlation spectroscopy signal relationship with blood flow. Neurophotonics. 2016 Jul; 3(3):031412. PMID: 27335889.
    View in: PubMed
  2. Uhlirova H, Kiliç K, Tian P, Thunemann M, Desjardins M, Saisan PA, Sakadžic S, Ness TV, Mateo C, Cheng Q, Weldy KL, Razoux F, Vandenberghe M, Cremonesi JA, Ferri CG, Nizar K, Sridhar VB, Steed TC, Abashin M, Fainman Y, Masliah E, Djurovic S, Andreassen OA, Silva GA, Boas DA, Kleinfeld D, Buxton RB, Einevoll GT, Dale AM, Devor A. Cell type specificity of neurovascular coupling in cerebral cortex. Elife. 2016; 5. PMID: 27244241.
    View in: PubMed
  3. Wang H, Akkin T, Magnain C, Wang R, Dubb J, Kostis WJ, Yaseen MA, Cramer A, Sakadžic S, Boas D. Polarization sensitive optical coherence microscopy for brain imaging. Opt Lett. 2016 May 15; 41(10):2213-6. PMID: 27176965.
    View in: PubMed
  4. Magnain C, Wang H, Sakadžic S, Fischl B, Boas DA. En face speckle reduction in optical coherence microscopy by frequency compounding. Opt Lett. 2016 May 1; 41(9):1925-8. PMID: 27128040.
    View in: PubMed
  5. Gutiérrez-Jiménez E, Cai C, Mikkelsen IK, Rasmussen PM, Angleys H, Merrild M, Mouridsen K, Jespersen SN, Lee J, Iversen NK, Sakadzic S, Østergaard L. Effect of electrical forepaw stimulation on capillary transit-time heterogeneity (CTH). J Cereb Blood Flow Metab. 2016 Feb 8. PMID: 26858243.
    View in: PubMed
  6. Yaseen MA, Srinivasan VJ, Gorczynska I, Fujimoto JG, Boas DA, Sakadžic S. Multimodal optical imaging system for in vivo investigation of cerebral oxygen delivery and energy metabolism. Biomed Opt Express. 2015 Dec 1; 6(12):4994-5007. PMID: 26713212.
    View in: PubMed
  7. Hayakawa K, Pham LD, Seo JH, Miyamoto N, Maki T, Terasaki Y, Sakadžic S, Boas D, van Leyen K, Waeber C, Kim KW, Arai K, Lo EH. CD200 restrains macrophage attack on oligodendrocyte precursors via toll-like receptor 4 downregulation. J Cereb Blood Flow Metab. 2016 Apr; 36(4):781-93. PMID: 26661156.
    View in: PubMed
  8. Sakadžic S. At long last, PAT hats for the lab rats. J Cereb Blood Flow Metab. 2015 Aug; 35(8):1223. PMID: 26082018; PMCID: PMC4527998 [Available on 08/01/16].
  9. Sakadžic S, Lee J, Boas DA, Ayata C. High-resolution in vivo optical imaging of stroke injury and repair. Brain Res. 2015 Oct 14; 1623:174-92. PMID: 25960347; PMCID: PMC4569527 [Available on 10/14/16].
  10. Gagnon L, Sakadžic S, Lesage F, Mandeville ET, Fang Q, Yaseen MA, Boas DA. Multimodal reconstruction of microvascular-flow distributions using combined two-photon microscopy and Doppler optical coherence tomography. Neurophotonics. 2015 Jan; 2(1):015008. PMID: 26157987; PMCID: PMC4478873 [Available on 01/01/16].
  11. von Bornstädt D, Houben T, Seidel JL, Zheng Y, Dilekoz E, Qin T, Sandow N, Kura S, Eikermann-Haerter K, Endres M, Boas DA, Moskowitz MA, Lo EH, Dreier JP, Woitzik J, Sakadžic S, Ayata C. Supply-demand mismatch transients in susceptible peri-infarct hot zones explain the origins of spreading injury depolarizations. Neuron. 2015 Mar 4; 85(5):1117-31. PMID: 25741731; PMCID: PMC4351476 [Available on 03/04/16].
  12. Gagnon L, Sakadžic S, Lesage F, Musacchia JJ, Lefebvre J, Fang Q, Yücel MA, Evans KC, Mandeville ET, Cohen-Adad J, Polimeni JR, Yaseen MA, Lo EH, Greve DN, Buxton RB, Dale AM, Devor A, Boas DA. Quantifying the microvascular origin of BOLD-fMRI from first principles with two-photon microscopy and an oxygen-sensitive nanoprobe. J Neurosci. 2015 Feb 25; 35(8):3663-75. PMID: 25716864; PMCID: PMC4339366.
  13. Magnain C, Augustinack JC, Konukoglu E, Frosch MP, Sakadžic S, Varjabedian A, Garcia N, Wedeen VJ, Boas DA, Fischl B. Optical coherence tomography visualizes neurons in human entorhinal cortex. Neurophotonics. 2015 Feb 9; 2(1):015004. PMID: 25741528.
    View in: PubMed
  14. Sakadžic S, Mandeville ET, Gagnon L, Musacchia JJ, Yaseen MA, Yucel MA, Lefebvre J, Lesage F, Dale AM, Eikermann-Haerter K, Ayata C, Srinivasan VJ, Lo EH, Devor A, Boas DA. Large arteriolar component of oxygen delivery implies a safe margin of oxygen supply to cerebral tissue. Nat Commun. 2014; 5:5734. PMID: 25483924; PMCID: PMC4260810.
  15. Devor A, Sakadzic S, Yaseen MA, Roussakis E, Tian P, Slovin H, Vanzetta I, Teng IC, Saisan PA, Sinks LE, Dale AM, Vinogradov SA, Boas DA. "Optical imaging of cortical circuit dynamics" in Neuromethods, vol. 85, Bruno Weber and Fritjof Helmchen, Editors. Functional Imaging of Cerebral Oxygenation with Intrinsic Optical Contrast and Phosphorescent Probes. 2014; 225-253.
  16. Srinivasan VJ, Mandeville ET, Can A, Blasi F, Climov M, Daneshmand A, Lee JH, Yu E, Radhakrishnan H, Lo EH, Sakadžic S, Eikermann-Haerter K, Ayata C. Multiparametric, longitudinal optical coherence tomography imaging reveals acute injury and chronic recovery in experimental ischemic stroke. PLoS One. 2013; 8(8):e71478. PMID: 23940761; PMCID: PMC3737090.
  17. Nizar K, Uhlirova H, Tian P, Saisan PA, Cheng Q, Reznichenko L, Weldy KL, Steed TC, Sridhar VB, MacDonald CL, Cui J, Gratiy SL, Sakadzic S, Boas DA, Beka TI, Einevoll GT, Chen J, Masliah E, Dale AM, Silva GA, Devor A. In vivo stimulus-induced vasodilation occurs without IP3 receptor activation and may precede astrocytic calcium increase. J Neurosci. 2013 May 8; 33(19):8411-22. PMID: 23658179; PMCID: PMC3712855.
  18. Yaseen MA, Sakadžic S, Wu W, Becker W, Kasischke KA, Boas DA. In vivo imaging of cerebral energy metabolism with two-photon fluorescence lifetime microscopy of NADH. Biomed Opt Express. 2013 Feb 1; 4(2):307-21. PMID: 23412419; PMCID: PMC3567717.
  19. Esipova TV, Ye X, Collins JE, Sakadžic S, Mandeville ET, Murray CB, Vinogradov SA. Dendritic upconverting nanoparticles enable in vivo multiphoton microscopy with low-power continuous wave sources. Proc Natl Acad Sci U S A. 2012 Dec 18; 109(51):20826-31. PMID: 23213211; PMCID: PMC3529031.
  20. Goergen CJ, Radhakrishnan H, Sakadžic S, Mandeville ET, Lo EH, Sosnovik DE, Srinivasan VJ. Optical coherence tractography using intrinsic contrast. Opt Lett. 2012 Sep 15; 37(18):3882-4. PMID: 23041891; PMCID: PMC3691965.
  21. Devor A, Sakadžic S, Srinivasan VJ, Yaseen MA, Nizar K, Saisan PA, Tian P, Dale AM, Vinogradov SA, Franceschini MA, Boas DA. Frontiers in optical imaging of cerebral blood flow and metabolism. J Cereb Blood Flow Metab. 2012 Jul; 32(7):1259-76. PMID: 22252238; PMCID: PMC3390808.
  22. Yuzawa I, Sakadžic S, Srinivasan VJ, Shin HK, Eikermann-Haerter K, Boas DA, Ayata C. Cortical spreading depression impairs oxygen delivery and metabolism in mice. J Cereb Blood Flow Metab. 2012 Feb; 32(2):376-86. PMID: 22008729; PMCID: PMC3272607.
  23. Baraghis E, Devor A, Fang Q, Srinivasan VJ, Wu W, Lesage F, Ayata C, Kasischke KA, Boas DA, Sakadzic S. Two-photon microscopy of cortical NADH fluorescence intensity changes: correcting contamination from the hemodynamic response. J Biomed Opt. 2011 Oct; 16(10):106003. PMID: 22029350; PMCID: PMC3206923.
  24. Devor A, Sakadzic S, Saisan PA, Yaseen MA, Roussakis E, Srinivasan VJ, Vinogradov SA, Rosen BR, Buxton RB, Dale AM, Boas DA. "Overshoot" of O2 is required to maintain baseline tissue oxygenation at locations distal to blood vessels. J Neurosci. 2011 Sep 21; 31(38):13676-81. PMID: 21940458; PMCID: PMC3188944.
  25. Carp SA, Roche-Labarbe N, Franceschini MA, Srinivasan VJ, Sakadžic S, Boas DA. Due to intravascular multiple sequential scattering, Diffuse Correlation Spectroscopy of tissue primarily measures relative red blood cell motion within vessels. Biomed Opt Express. 2011 Jul 1; 2(7):2047-54. PMID: 21750779; PMCID: PMC3130588.
  26. Sakadžic S, Roussakis E, Yaseen MA, Mandeville ET, Srinivasan VJ, Arai K, Ruvinskaya S, Wu W, Devor A, Lo EH, Vinogradov SA, Boas DA. J. Vis. Exp. Cerebral blood oxygenation measurement based on oxygen-dependent quenching of phosphorescence. 2011; (51).
  27. Tian P, Devor A, Sakadzic S, Dale AM, Boas DA. Monte Carlo simulation of the spatial resolution and depth sensitivity of two-dimensional optical imaging of the brain. J Biomed Opt. 2011 Jan-Feb; 16(1):016006. PMID: 21280912; PMCID: PMC3041814.
  28. Yaseen MA, Srinivasan VJ, Sakadžic S, Radhakrishnan H, Gorczynska I, Wu W, Fujimoto JG, Boas DA. Microvascular oxygen tension and flow measurements in rodent cerebral cortex during baseline conditions and functional activation. J Cereb Blood Flow Metab. 2011 Apr; 31(4):1051-63. PMID: 21179069; PMCID: PMC3070982.
  29. Sakadzic S, Roussakis E, Yaseen MA, Mandeville ET, Srinivasan VJ, Arai K, Ruvinskaya S, Devor A, Lo EH, Vinogradov SA, Boas DA. Two-photon high-resolution measurement of partial pressure of oxygen in cerebral vasculature and tissue. Nat Methods. 2010 Sep; 7(9):755-9. PMID: 20693997; PMCID: PMC2932799.
  30. Srinivasan VJ, Sakadzic S, Gorczynska I, Ruvinskaya S, Wu W, Fujimoto JG, Boas DA. Quantitative cerebral blood flow with optical coherence tomography. Opt Express. 2010 Feb 1; 18(3):2477-94. PMID: 20174075; PMCID: PMC2837842.
  31. Sukhotinsky I, Yaseen MA, Sakadzic S, Ruvinskaya S, Sims JR, Boas DA, Moskowitz MA, Ayata C. Perfusion pressure-dependent recovery of cortical spreading depression is independent of tissue oxygenation over a wide physiologic range. J Cereb Blood Flow Metab. 2010 Jun; 30(6):1168-77. PMID: 20087371; PMCID: PMC2921789.
  32. Yaseen MA, Srinivasan VJ, Sakadzic S, Wu W, Ruvinskaya S, Vinogradov SA, Boas DA. Optical monitoring of oxygen tension in cortical microvessels with confocal microscopy. Opt Express. 2009 Dec 7; 17(25):22341-50. PMID: 20052157; PMCID: PMC2857779.
  33. Srinivasan VJ, Sakadzic S, Gorczynska I, Ruvinskaya S, Wu W, Fujimoto JG, Boas DA. Depth-resolved microscopy of cortical hemodynamics with optical coherence tomography. Opt Lett. 2009 Oct 15; 34(20):3086-8. PMID: 19838234; PMCID: PMC2778254.
  34. Lebedev AY, Cheprakov AV, Sakadzic S, Boas DA, Wilson DF, Vinogradov SA. Dendritic phosphorescent probes for oxygen imaging in biological systems. ACS Appl Mater Interfaces. 2009 Jun; 1(6):1292-304. PMID: 20072726; PMCID: PMC2805241.
  35. Sakadzic S, Yuan S, Dilekoz E, Ruvinskaya S, Vinogradov SA, Ayata C, Boas DA. Simultaneous imaging of cerebral partial pressure of oxygen and blood flow during functional activation and cortical spreading depression. Appl Opt. 2009 Apr 1; 48(10):D169-77. PMID: 19340106; PMCID: PMC2692697.
  36. Sakadzic S, Demirbas U, Mempel TR, Moore A, Ruvinskaya S, Boas DA, Sennaroglu A, Kaertner FX, Fujimoto JG. Multi-photon microscopy with a low-cost and highly efficient Cr:LiCAF laser. Opt Express. 2008 Dec 8; 16(25):20848-63. PMID: 19065223; PMCID: PMC2689708.
  37. Fang Q, Sakadzic S, Ruvinskaya L, Devor A, Dale AM, Boas DA. Oxygen advection and diffusion in a three- dimensional vascular anatomical network. Opt Express. 2008 Oct 27; 16(22):17530-41. PMID: 18958033; PMCID: PMC2584207.
  38. Sakadzic S, Wang LV. Correlation transfer equation for multiply scattered light modulated by an ultrasonic pulse. J Opt Soc Am A Opt Image Sci Vis. 2007 Sep; 24(9):2797-806. PMID: 17767248.
    View in: PubMed
  39. Kothapalli SR, Sakadzic S, Kim C, Wang LV. Imaging optically scattering objects with ultrasound-modulated optical tomography. Opt Lett. 2007 Aug 15; 32(16):2351-3. PMID: 17700782.
    View in: PubMed
  40. Sakadzic S, Wang LV. Correlation transfer equation for ultrasound-modulated multiply scattered light. Phys Rev E Stat Nonlin Soft Matter Phys. 2006 Sep; 74(3 Pt 2):036618. PMID: 17025775.
    View in: PubMed
  41. Zemp R, Sakadzic S, Wang LV. Stochastic explanation of speckle contrast detection in ultrasound-modulated optical tomography. Phys Rev E Stat Nonlin Soft Matter Phys. 2006 Jun; 73(6 Pt 1):061920. PMID: 16906877.
    View in: PubMed
  42. Sakadzic S, Wang LV. Correlation transfer and diffusion of ultrasound-modulated multiply scattered light. Phys Rev Lett. 2006 Apr 28; 96(16):163902. PMID: 16712231.
    View in: PubMed
  43. Sakadzic S, Wang LV. Modulation of multiply scattered coherent light by ultrasonic pulses: an analytical model. Phys Rev E Stat Nonlin Soft Matter Phys. 2005 Sep; 72(3 Pt 2):036620. PMID: 16241605.
    View in: PubMed
  44. Sakadzic S, Wang LV. High-resolution ultrasound-modulated optical tomography in biological tissues. Opt Lett. 2004 Dec 1; 29(23):2770-2. PMID: 15605500.
    View in: PubMed
  45. Petrovic ZL, Sakadzic S, Spasojevic N, Matsui J, Makabe T. Mater. Sci. Forum. Comparison of direct numerical procedure and Monte Carlo technique to determine the charging effects in submicron structures. 2004; 453-454:9-14.
  46. Li J, Sakadzic S, Ku G, Wang LV. Transmission- and side-detection configurations in ultrasound-modulated optical tomography of thick biological tissues. Appl Opt. 2003 Jul 1; 42(19):4088-94. PMID: 12868851.
    View in: PubMed
  47. Rahman A, Hammarsten EC, Sakadzic S, Rocca JJ, Wyart JF. Physica Scripta. Identification of n=4, Delta n=0 transitions in the spectra of nickel-like cadmium ions from a capillary discharge plasma column. 2003; 67(5):414-419.
  48. Sakadzic S, Wang LV. Ultrasonic modulation of multiply scattered coherent light: an analytical model for anisotropically scattering media. Phys Rev E Stat Nonlin Soft Matter Phys. 2002 Aug; 66(2 Pt 2):026603. PMID: 12241307.
    View in: PubMed
  49. Raspopovic Z, Sakadzic S, Petrovic ZL, Makabe T. J. Phys. D: Appl. Phys. Diffusion of electrons in time-dependent E(t) x B(t) fields. 2000; 33(11):1298-1302.
  50. Dyatko NA, Napartovich AP, Sakadzic S, Petrovic Z, Raspopovic Z. J. Phys. D: Appl. Phys. On the possibility of negative electron mobility in a decaying plasma. 2000; 33(4):375-380.
  51. Raspopovic Z, Sakadzic S, Bzenic SA, Petrovic ZL. IEEE Trans. Plasma Sci. Benchmark calculations for Monte Carlo simulations of electron transport. 1999; 27(5):1241-1248.
  52. Bzenic S, Raspopovic ZM, Sakadzic S, Petrovic ZL. IEEE Trans. Plasma Sci. Relaxation of electron swarm energy distribution functions in time-varying fields. 1999; 27(1):78-79.
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