Lymphocyte Specific Protein Tyrosine Kinase p56(lck)
"Lymphocyte Specific Protein Tyrosine Kinase p56(lck)" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
This enzyme is a lymphoid-specific src family tyrosine kinase that is critical for T-cell development and activation. Lck is associated with the cytoplasmic domains of CD4, CD8 and the beta-chain of the IL-2 receptor, and is thought to be involved in the earliest steps of TCR-mediated T-cell activation.
MeSH Number(s)
D08.811.913.696.620.682.725.800.315
D12.776.624.664.700.128
Concept/Terms
Lymphocyte Specific Protein Tyrosine Kinase p56(lck)- Lymphocyte Specific Protein Tyrosine Kinase p56(lck)
- p56 lck
- Proto-Oncogene Protein c-lck
- Protein c-lck, Proto-Oncogene
- Proto Oncogene Protein c lck
- c-lck, Proto-Oncogene Protein
- Proto-Oncogene Protein lck
- Protein lck, Proto-Oncogene
- Proto Oncogene Protein lck
- lck, Proto-Oncogene Protein
- lck Kinase
- Kinase, lck
- Protein Tyrosine Kinase p56(lck)
Below are MeSH descriptors whose meaning is more general than "Lymphocyte Specific Protein Tyrosine Kinase p56(lck)".
Below are MeSH descriptors whose meaning is more specific than "Lymphocyte Specific Protein Tyrosine Kinase p56(lck)".
This graph shows the total number of publications written about "Lymphocyte Specific Protein Tyrosine Kinase p56(lck)" by people in Harvard Catalyst Profiles by year, and whether "Lymphocyte Specific Protein Tyrosine Kinase p56(lck)" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1993 | 0 | 7 | 7 |
| 1994 | 0 | 6 | 6 |
| 1995 | 0 | 9 | 9 |
| 1996 | 0 | 4 | 4 |
| 1997 | 0 | 3 | 3 |
| 1998 | 3 | 1 | 4 |
| 1999 | 1 | 3 | 4 |
| 2000 | 1 | 2 | 3 |
| 2001 | 1 | 1 | 2 |
| 2002 | 0 | 2 | 2 |
| 2003 | 1 | 2 | 3 |
| 2004 | 1 | 0 | 1 |
| 2005 | 0 | 1 | 1 |
| 2008 | 1 | 1 | 2 |
| 2009 | 2 | 1 | 3 |
| 2012 | 1 | 1 | 2 |
| 2013 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2015 | 1 | 0 | 1 |
| 2016 | 1 | 0 | 1 |
| 2018 | 0 | 1 | 1 |
| 2022 | 1 | 0 | 1 |
Below are the most recent publications written about "Lymphocyte Specific Protein Tyrosine Kinase p56(lck)" by people in Profiles.
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Therapeutic targeting of LCK tyrosine kinase and mTOR signaling in T-cell acute lymphoblastic leukemia. Blood. 2022 10 27; 140(17):1891-1906.
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CEACAM1 promotes CD8+ T cell responses and improves control of a chronic viral infection. Nat Commun. 2018 07 02; 9(1):2561.
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Binding of the cytoplasmic domain of CD28 to the plasma membrane inhibits Lck recruitment and signaling. Sci Signal. 2016 07 26; 9(438):ra75.
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A Transmembrane Domain GGxxG Motif in CD4 Contributes to Its Lck-Independent Function but Does Not Mediate CD4 Dimerization. PLoS One. 2015; 10(7):e0132333.
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An immunosuppressive antibody-drug conjugate. J Am Chem Soc. 2015 Mar 11; 137(9):3229-32.
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Expression of the SNARE protein SNAP-23 is essential for cell survival. PLoS One. 2015; 10(2):e0118311.
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N-Octanoyl dopamine transiently inhibits T cell proliferation via G1 cell-cycle arrest and inhibition of redox-dependent transcription factors. J Leukoc Biol. 2014 Sep; 96(3):453-62.
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Cross talk between CD3 and CD28 is spatially modulated by protein lateral mobility. Mol Cell Biol. 2014 Mar; 34(6):955-64.
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T cell Ig and mucin domain-containing protein 3 is recruited to the immune synapse, disrupts stable synapse formation, and associates with receptor phosphatases. J Immunol. 2014 Jan 15; 192(2):782-91.
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Heat shock protein 90 is critical for regulation of phenotype and functional activity of human T lymphocytes and NK cells. J Immunol. 2013 Feb 01; 190(3):1360-71.