Cyclic Nucleotide Phosphodiesterases, Type 1
"Cyclic Nucleotide Phosphodiesterases, Type 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A CALCIUM and CALMODULIN-dependent cyclic nucleotide phosphodiesterase subfamily. The three members of this family are referred to as type 1A, type 1B, and type 1C and are each product of a distinct gene. In addition, multiple enzyme variants of each subtype can be produced due to multiple alternative mRNA splicing. Although the type 1 enzymes are classified as 3',5'-cyclic-AMP phosphodiesterases (EC 3.1.4.17), some members of this class have additional specificity for CYCLIC GMP.
MeSH Number(s)
D08.811.277.352.640.150.100
D08.811.277.352.640.155.100
D12.644.360.008.100
D12.644.360.009.100
D12.776.476.008.100
D12.776.476.009.100
Concept/Terms
Cyclic Nucleotide Phosphodiesterases, Type 1- Cyclic Nucleotide Phosphodiesterases, Type 1
- Ca++ Calmodulin Dependent Cyclic AMP Phosphodiesterase
- Ca-CaM-Phosphodiesterase
- Ca CaM Phosphodiesterase
- Calcium-Calmodulin-Dependent Phosphodiesterase
- Calcium Calmodulin Dependent Phosphodiesterase
- Phosphodiesterase, Calcium-Calmodulin-Dependent
- PDE1 Phosphodiesterases
- Phosphodiesterases, PDE1
- Calmodulin Phosphodiesterase
- Calmodulin-Dependent cGMP Phosphodiesterase
- Calmodulin Dependent cGMP Phosphodiesterase
- Phosphodiesterase, Calmodulin-Dependent cGMP
- cGMP Phosphodiesterase, Calmodulin-Dependent
- Calmodulin-Dependent Phosphodiesterase
- Calmodulin Dependent Phosphodiesterase
- Cyclic Nucleotide Phosphodiesterase PDE1 Family
- Cyclic Nucleotide Phosphodiesterases, Type I
- Ca(2+)-CaM-Stimulated PDE
- Calcium-Calmodulin-Stimulated Cyclic AMP Phosphodiesterase
- Calcium Calmodulin Stimulated Cyclic AMP Phosphodiesterase
Below are MeSH descriptors whose meaning is more general than "Cyclic Nucleotide Phosphodiesterases, Type 1".
- Chemicals and Drugs [D]
- Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
- Hydrolases [D08.811.277]
- Esterases [D08.811.277.352]
- Phosphoric Diester Hydrolases [D08.811.277.352.640]
- 3',5'-Cyclic-AMP Phosphodiesterases [D08.811.277.352.640.150]
- Cyclic Nucleotide Phosphodiesterases, Type 1 [D08.811.277.352.640.150.100]
- 3',5'-Cyclic-GMP Phosphodiesterases [D08.811.277.352.640.155]
- Cyclic Nucleotide Phosphodiesterases, Type 1 [D08.811.277.352.640.155.100]
- Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
- Intracellular Signaling Peptides and Proteins [D12.644.360]
- 3',5'-Cyclic-AMP Phosphodiesterases [D12.644.360.008]
- Cyclic Nucleotide Phosphodiesterases, Type 1 [D12.644.360.008.100]
- 3',5'-Cyclic-GMP Phosphodiesterases [D12.644.360.009]
- Cyclic Nucleotide Phosphodiesterases, Type 1 [D12.644.360.009.100]
- Proteins [D12.776]
- Intracellular Signaling Peptides and Proteins [D12.776.476]
- 3',5'-Cyclic-AMP Phosphodiesterases [D12.776.476.008]
- Cyclic Nucleotide Phosphodiesterases, Type 1 [D12.776.476.008.100]
- 3',5'-Cyclic-GMP Phosphodiesterases [D12.776.476.009]
- Cyclic Nucleotide Phosphodiesterases, Type 1 [D12.776.476.009.100]
Below are MeSH descriptors whose meaning is more specific than "Cyclic Nucleotide Phosphodiesterases, Type 1".
This graph shows the total number of publications written about "Cyclic Nucleotide Phosphodiesterases, Type 1" by people in Harvard Catalyst Profiles by year, and whether "Cyclic Nucleotide Phosphodiesterases, Type 1" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2015 | 1 | 0 | 1 |
| 2016 | 0 | 1 | 1 |
| 2019 | 1 | 0 | 1 |
Below are the most recent publications written about "Cyclic Nucleotide Phosphodiesterases, Type 1" by people in Profiles.
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PDE1 inhibition facilitates proteasomal degradation of misfolded proteins and protects against cardiac proteinopathy. Sci Adv. 2019 05; 5(5):eaaw5870.
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Oligodendrocyte gene expression is reduced by and influences effects of chronic social stress in mice. Genes Brain Behav. 2019 01; 18(1):e12475.
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Associations between smoking behavior-related alleles and the risk of melanoma. Oncotarget. 2016 Jul 26; 7(30):47366-47375.
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Phosphodiesterase 1 regulation is a key mechanism in vascular aging. Clin Sci (Lond). 2015 Dec; 129(12):1061-75.
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Role of cAMP-phosphodiesterase 1C signaling in regulating growth factor receptor stability, vascular smooth muscle cell growth, migration, and neointimal hyperplasia. Circ Res. 2015 Mar 27; 116(7):1120-32.
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MicroRNA-378 controls classical brown fat expansion to counteract obesity. Nat Commun. 2014 Aug 22; 5:4725.
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Cyclic nucleotide phosphodiesterase 1A: a key regulator of cardiac fibroblast activation and extracellular matrix remodeling in the heart. Basic Res Cardiol. 2011 Nov; 106(6):1023-39.
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Cyclic nucleotide phosphodiesterase 1 regulates lysosome-dependent type I collagen protein degradation in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 2011 Mar; 31(3):616-23.
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Ca2+/calmodulin-stimulated PDE1 regulates the beta-catenin/TCF signaling through PP2A B56 gamma subunit in proliferating vascular smooth muscle cells. FEBS J. 2010 Dec; 277(24):5026-39.
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Role of Ca2+/calmodulin-stimulated cyclic nucleotide phosphodiesterase 1 in mediating cardiomyocyte hypertrophy. Circ Res. 2009 Nov 06; 105(10):956-64.