Cyclic Nucleotide Phosphodiesterases, Type 2
"Cyclic Nucleotide Phosphodiesterases, Type 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A cyclic nucleotide phosphodiesterase subfamily that is activated by the binding of CYCLIC GMP to an allosteric domain found on the enzyme. Multiple enzyme variants of this subtype can be produced due to multiple alternative mRNA splicing. The subfamily is expressed in a broad variety of tissues and may play a role in mediating cross-talk between CYCLIC GMP and CYCLIC CMP pathways. Although the type 2 enzymes are classified as 3',5'-cyclic-AMP phosphodiesterases (EC 3.1.4.17), members of this class have additional specificity for CYCLIC GMP.
MeSH Number(s)
D08.811.277.352.640.150.200
D08.811.277.352.640.155.200
D12.644.360.008.200
D12.644.360.009.200
D12.776.476.008.200
D12.776.476.009.200
Concept/Terms
Cyclic Nucleotide Phosphodiesterases, Type 2- Cyclic Nucleotide Phosphodiesterases, Type 2
- PDE2 Phosphodiesterases
- PDE2 Phosphodiesterase
- Cyclic GMP-Stimulated Phosphodiesterase
- Cyclic GMP Stimulated Phosphodiesterase
- Phosphodiesterase, Cyclic GMP-Stimulated
- Cyclic Nucleotide Phosphodiesterase PDE2 Family
Cyclic Nucleotide Phosphodiesterases, Type 2A- Cyclic Nucleotide Phosphodiesterases, Type 2A
- Phosphodiesterase 2A
- cGMP-Dependent 3',5'-Cyclic Phosphodiesterase
- 3',5'-Cyclic Phosphodiesterase, cGMP-Dependent
- cGMP Dependent 3',5' Cyclic Phosphodiesterase
Below are MeSH descriptors whose meaning is more general than "Cyclic Nucleotide Phosphodiesterases, Type 2".
- Chemicals and Drugs [D]
- Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
- Hydrolases [D08.811.277]
- Esterases [D08.811.277.352]
- Phosphoric Diester Hydrolases [D08.811.277.352.640]
- 3',5'-Cyclic-AMP Phosphodiesterases [D08.811.277.352.640.150]
- Cyclic Nucleotide Phosphodiesterases, Type 2 [D08.811.277.352.640.150.200]
- 3',5'-Cyclic-GMP Phosphodiesterases [D08.811.277.352.640.155]
- Cyclic Nucleotide Phosphodiesterases, Type 2 [D08.811.277.352.640.155.200]
- Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
- Intracellular Signaling Peptides and Proteins [D12.644.360]
- 3',5'-Cyclic-AMP Phosphodiesterases [D12.644.360.008]
- Cyclic Nucleotide Phosphodiesterases, Type 2 [D12.644.360.008.200]
- 3',5'-Cyclic-GMP Phosphodiesterases [D12.644.360.009]
- Cyclic Nucleotide Phosphodiesterases, Type 2 [D12.644.360.009.200]
- Proteins [D12.776]
- Intracellular Signaling Peptides and Proteins [D12.776.476]
- 3',5'-Cyclic-AMP Phosphodiesterases [D12.776.476.008]
- Cyclic Nucleotide Phosphodiesterases, Type 2 [D12.776.476.008.200]
- 3',5'-Cyclic-GMP Phosphodiesterases [D12.776.476.009]
- Cyclic Nucleotide Phosphodiesterases, Type 2 [D12.776.476.009.200]
Below are MeSH descriptors whose meaning is more specific than "Cyclic Nucleotide Phosphodiesterases, Type 2".
This graph shows the total number of publications written about "Cyclic Nucleotide Phosphodiesterases, Type 2" by people in Harvard Catalyst Profiles by year, and whether "Cyclic Nucleotide Phosphodiesterases, Type 2" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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2008 | 1 | 0 | 1 |
2020 | 0 | 1 | 1 |
Below are the most recent publications written about "Cyclic Nucleotide Phosphodiesterases, Type 2" by people in Profiles.
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Renewal and Differentiation of GCD Necklace Olfactory Sensory Neurons. Chem Senses. 2020 05 29; 45(5):333-346.
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Inhibition of phosphodiesterase 2 reverses gp91phox oxidase-mediated depression- and anxiety-like behavior. Neuropharmacology. 2018 12; 143:176-185.
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Epigenetic Regulation of Phosphodiesterases 2A and 3A Underlies Compromised ß-Adrenergic Signaling in an iPSC Model of Dilated Cardiomyopathy. Cell Stem Cell. 2015 Jul 02; 17(1):89-100.
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Msn2 coordinates a stoichiometric gene expression program. Curr Biol. 2013 Dec 02; 23(23):2336-45.
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N-acetylglucosamine induces white to opaque switching, a mating prerequisite in Candida albicans. PLoS Pathog. 2010 Mar 12; 6(3):e1000806.
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Soluble guanylyl cyclase contributes to ventilator-induced lung injury in mice. Am J Physiol Lung Cell Mol Physiol. 2008 Dec; 295(6):L1056-65.