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Mark A. Perrella, M.D.

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Overview
Dr. Perrella is an Associate Professor of Medicine at Harvard Medical School and an Associate Physician in Pulmonary and Critical Care, and Newborn Medicine, at Brigham and Women’s Hospital in Boston, MA. Dr. Perrella has received a number of honors and awards throughout his career including the Internal Medicine Outstanding Achievement Award at the Mayo Graduate School of Medicine; Mayo Foundation Scholar in the Division of Thoracic Diseases and Internal Medicine; Mayo Alumni Association’s Donald C. Balfour Award for Meritorious Research; the Mayo Foundation Clinician Scholar Award; and election into the American Society for Clinical Investigation. Dr. Perrella is a National Institutes of Health (NIH) funded investigator, and he is devoted to the scientific peer review process including his involvement in serving on NIH study sections and his appointment as an Associate Editor of the American Journal of Respiratory Cell and Molecular Biology. The Perrella laboratory is interested in: 1) The regulation and biology of genes important for the modulation of inflammation and oxidative stress in systemic disease processes. A gene of particular interest is heme oxygenase-1, and its downstream product carbon monoxide, in mediating the pathobiology of sepsis and acute lung injury. 2) The regulation and biology of genes selectively expressed in muscle cells (smooth or striated). A recent focus has been the striated preferentially expressed gene (Speg) and its role in fetal heart development and function. 3) The commitment and differentiation of progenitor cells during the evolution of disease processes. The ultimate goal is to develop novel cell-based strategies for the treatment of cardiopulmonary and vascular diseases for patients of all ages, from premature infants to adults.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01GM136804 (PERRELLA, MARK A) Apr 1, 2020 - Jan 31, 2025
    NIH
    Mesenchymal Stromal Cells, Autophagy, and the Host Response to Systemic Bacterial Infection
    Role: Principal Investigator
  2. U01AI138318 (LEDERER, JAMES A. ;PERRELLA, MARK A) Apr 1, 2018 - Mar 31, 2024
    NIH
    Therapy of acute radiation syndrome and its complications by mesenchymal stromal cells conditioned with Toll-like receptor 9 agonists
    Role: Co-Principal Investigator
  3. R01GM118456 (PERRELLA, MARK A) May 10, 2016 - Feb 28, 2021
    NIH
    Regulation of Neutrophil Function by Mesenchymal Stromal Cells During Sepsis
    Role: Principal Investigator
  4. P01HL108801 (PERRELLA, MARK A) Aug 15, 2011 - Jun 30, 2017
    NIH
    Carbon Monoxide: Novel Opportunities for Therapy
    Role: Principal Investigator
  5. R01HL102897 (PERRELLA, MARK A) Dec 2, 2010 - Nov 30, 2015
    NIH
    Cardiomyocyte Differentiation Regulates Cardiac Function
    Role: Principal Investigator

Bibliographic
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.