Receptor, Platelet-Derived Growth Factor alpha
"Receptor, Platelet-Derived Growth Factor alpha" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A PDGF receptor that binds specifically to both PDGF-A chains and PDGF-B chains. It contains a protein-tyrosine kinase activity that is involved in SIGNAL TRANSDUCTION.
MeSH Number(s)
D08.811.913.696.620.682.725.400.900.500
D12.776.543.750.060.625.300
D12.776.543.750.750.400.630.300
Concept/Terms
Receptor, Platelet-Derived Growth Factor alpha- Receptor, Platelet-Derived Growth Factor alpha
- CD140a Antigen
- Antigen, CD140a
- CD140a Antigens
- PDGF alpha Receptor
- PDGFR2
- PDGFRalpha
- Platelet-Derived Growth Factor alpha Receptor
- Platelet Derived Growth Factor alpha Receptor
- Receptor, PDGF alpha
- Antigens, CD140a
- PDGF-R-alpha
Below are MeSH descriptors whose meaning is more general than "Receptor, Platelet-Derived Growth Factor alpha".
- Chemicals and Drugs [D]
- Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
- Transferases [D08.811.913]
- Phosphotransferases [D08.811.913.696]
- Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
- Protein Kinases [D08.811.913.696.620.682]
- Protein-Tyrosine Kinases [D08.811.913.696.620.682.725]
- Receptor Protein-Tyrosine Kinases [D08.811.913.696.620.682.725.400]
- Receptors, Platelet-Derived Growth Factor [D08.811.913.696.620.682.725.400.900]
- Receptor, Platelet-Derived Growth Factor alpha [D08.811.913.696.620.682.725.400.900.500]
- Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
- Membrane Proteins [D12.776.543]
- Receptors, Cell Surface [D12.776.543.750]
- Receptor Protein-Tyrosine Kinases [D12.776.543.750.060]
- Receptors, Platelet-Derived Growth Factor [D12.776.543.750.060.625]
- Receptor, Platelet-Derived Growth Factor alpha [D12.776.543.750.060.625.300]
- Receptors, Peptide [D12.776.543.750.750]
- Receptors, Growth Factor [D12.776.543.750.750.400]
- Receptors, Platelet-Derived Growth Factor [D12.776.543.750.750.400.630]
- Receptor, Platelet-Derived Growth Factor alpha [D12.776.543.750.750.400.630.300]
Below are MeSH descriptors whose meaning is more specific than "Receptor, Platelet-Derived Growth Factor alpha".
This graph shows the total number of publications written about "Receptor, Platelet-Derived Growth Factor alpha" by people in Harvard Catalyst Profiles by year, and whether "Receptor, Platelet-Derived Growth Factor alpha" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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1995 | 0 | 1 | 1 |
1996 | 0 | 1 | 1 |
1997 | 0 | 1 | 1 |
1998 | 0 | 2 | 2 |
1999 | 0 | 1 | 1 |
2000 | 2 | 0 | 2 |
2001 | 0 | 3 | 3 |
2002 | 1 | 1 | 2 |
2003 | 4 | 2 | 6 |
2004 | 4 | 2 | 6 |
2005 | 1 | 1 | 2 |
2006 | 6 | 4 | 10 |
2007 | 2 | 6 | 8 |
2008 | 3 | 9 | 12 |
2009 | 6 | 6 | 12 |
2010 | 6 | 4 | 10 |
2011 | 3 | 3 | 6 |
2012 | 2 | 9 | 11 |
2013 | 9 | 4 | 13 |
2014 | 5 | 7 | 12 |
2015 | 3 | 7 | 10 |
2016 | 5 | 3 | 8 |
2017 | 4 | 4 | 8 |
2018 | 4 | 7 | 11 |
2019 | 4 | 4 | 8 |
2020 | 5 | 4 | 9 |
2021 | 4 | 2 | 6 |
2022 | 1 | 2 | 3 |
2023 | 2 | 4 | 6 |
2024 | 0 | 1 | 1 |
Below are the most recent publications written about "Receptor, Platelet-Derived Growth Factor alpha" by people in Profiles.
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Clinical Benefit of Avapritinib in KIT-Mutant Gastrointestinal Stromal Tumors: A Post Hoc Analysis of the Phase I NAVIGATOR and Phase I/II CS3007-001 Studies. Clin Cancer Res. 2024 02 16; 30(4):719-728.
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PPAR? agonist treatment reduces fibroadipose tissue in secondary lymphedema by exhausting fibroadipogenic PDGFRa+ mesenchymal cells. JCI Insight. 2023 Dec 22; 8(24).
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Hypomyelination, hypodontia and craniofacial abnormalities in a Polr3b mouse model of leukodystrophy. Brain. 2023 12 01; 146(12):5070-5085.
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Genetic alterations that deregulate RB and PDGFRA signaling pathways drive tumor progression in IDH2-mutant astrocytoma. Acta Neuropathol Commun. 2023 11 27; 11(1):186.
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Integration of Genomic Sequencing Drives Therapeutic Targeting of PDGFRA in T-Cell Acute Lymphoblastic Leukemia/Lymphoblastic Lymphoma. Clin Cancer Res. 2023 11 14; 29(22):4613-4626.
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Molecular Advances in the Treatment of Advanced Gastrointestinal Stromal Tumor. Oncologist. 2023 08 03; 28(8):671-681.
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Modeling epigenetic lesions that cause gliomas. Cell. 2023 08 17; 186(17):3674-3685.e14.
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NCCN Guidelines® Insights: Gastrointestinal Stromal Tumors, Version 2.2022. J Natl Compr Canc Netw. 2022 11; 20(11):1204-1214.
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Platelet-derived growth factor (PDGF) cross-signaling via non-corresponding receptors indicates bypassed signaling in colorectal cancer. Oncotarget. 2022 10 19; 13:1140-1152.
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Integrated Antitumor Activities of Cellular Immunotherapy with CIK Lymphocytes and Interferons against KIT/PDGFRA Wild Type GIST. Int J Mol Sci. 2022 Sep 08; 23(18).