Kininogen, High-Molecular-Weight
"Kininogen, High-Molecular-Weight" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A plasma protein, molecular weight of 110 kD, that normally exists in plasma in a 1:1 complex with PREKALLIKREIN. HMWK is split by plasma kallikrein to produce BRADYKININ. The complex is a cofactor in the activation of coagulation factor XII. The product of this reaction, XIIa, in turn activates prekallikrein to KALLIKREINS. (From Stedman, 26th ed)
MeSH Number(s)
D12.644.276.812.654.350
D12.776.124.125.635.480
D12.776.467.812.654.350
D12.776.811.420.350
D23.119.630.480
D23.469.050.375.425.350
D23.529.812.654.350
Concept/Terms
Kininogen, High-Molecular-Weight- Kininogen, High-Molecular-Weight
- Kininogen, High Molecular Weight
- High Molecular Weight Kininogens
- Kininogens, High Molecular Weight
- HMWK
- High-Molecular-Weight Kininogens
- Kininogens, High-Molecular-Weight
- High-Molecular-Weight Kininogen
- Fitzgerald Factor
- High Molecular Weight Kininogen
Below are MeSH descriptors whose meaning is more general than "Kininogen, High-Molecular-Weight".
Below are MeSH descriptors whose meaning is more specific than "Kininogen, High-Molecular-Weight".
This graph shows the total number of publications written about "Kininogen, High-Molecular-Weight" by people in Harvard Catalyst Profiles by year, and whether "Kininogen, High-Molecular-Weight" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 1 | 0 | 1 |
| 2007 | 1 | 0 | 1 |
| 2011 | 1 | 1 | 2 |
| 2013 | 1 | 0 | 1 |
Below are the most recent publications written about "Kininogen, High-Molecular-Weight" by people in Profiles.
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An antibody against HK blocks Alzheimer's disease peptide ß-amyloid-induced bradykinin release in human plasma. Proc Natl Acad Sci U S A. 2019 11 12; 116(46):22921-22923.
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The high-molecular-weight kininogen domain 5 is an intrinsically unstructured protein and its interaction with ferritin is metal mediated. Protein Sci. 2014 Aug; 23(8):1013-22.
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Plasma kininogen and kininogen fragments are biomarkers of progressive renal decline in type 1 diabetes. Kidney Int. 2013 Jun; 83(6):1177-84.
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Ferritin blocks inhibitory effects of two-chain high molecular weight kininogen (HKa) on adhesion and survival signaling in endothelial cells. PLoS One. 2012; 7(7):e40030.
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High molecular weight kininogen activates B2 receptor signaling pathway in human vascular endothelial cells. J Biol Chem. 2011 Jul 15; 286(28):24561-71.
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Biochemical characterization of a novel high-affinity and specific plasma kallikrein inhibitor. Br J Pharmacol. 2011 Apr; 162(7):1639-49.
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Genome-wide association study for adiponectin levels in Filipino women identifies CDH13 and a novel uncommon haplotype at KNG1-ADIPOQ. Hum Mol Genet. 2010 Dec 15; 19(24):4955-64.
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Identification of coagulation factor XI as a ligand for platelet apolipoprotein E receptor 2 (ApoER2). Arterioscler Thromb Vasc Biol. 2009 Oct; 29(10):1602-7.
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Identification of lipopolysaccharide binding site on high molecular weight kininogen. Biochem Biophys Res Commun. 2008 Feb 22; 366(4):938-43.
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Myeloperoxidase interacts with endothelial cell-surface cytokeratin 1 and modulates bradykinin production by the plasma Kallikrein-Kinin system. Am J Pathol. 2007 Jul; 171(1):349-60.