DNA Polymerase I

"DNA Polymerase I" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A DNA-dependent DNA polymerase characterized in prokaryotes and may be present in higher organisms. It has both 3'-5' and 5'-3' exonuclease activity, but cannot use native double-stranded DNA as template-primer. It is not inhibited by sulfhydryl reagents and is active in both DNA synthesis and repair. EC 2.7.7.7.

Descriptor ID

D004256

MeSH Number(s)

D08.811.913.696.445.308.300.225

Concept/Terms

DNA Polymerase I

Below are MeSH descriptors whose meaning is more general than "DNA Polymerase I".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Nucleotidyltransferases [D08.811.913.696.445]
DNA Nucleotidyltransferases [D08.811.913.696.445.308]
DNA-Directed DNA Polymerase [D08.811.913.696.445.308.300]
DNA Polymerase I [D08.811.913.696.445.308.300.225]

Below are MeSH descriptors whose meaning is related to "DNA Polymerase I".

Below are MeSH descriptors whose meaning is more specific than "DNA Polymerase I".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "DNA Polymerase I" by people in Harvard Catalyst Profiles by year, and whether "DNA Polymerase I" was a major or minor topic of these publication.

Bar chart showing 17 publications over 13 distinct years, with a maximum of 2 publications in 1995 and 1998 and 2000 and 2012

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1994	1	0	1
1995	1	1	2
1997	1	0	1
1998	0	2	2
1999	1	0	1
2000	1	1	2
2002	1	0	1
2004	0	1	1
2012	1	1	2
2013	0	1	1
2015	0	1	1
2016	1	0	1
2018	0	1	1

Below are the most recent publications written about "DNA Polymerase I" by people in Profiles.

CTC1-STN1 coordinates G- and C-strand synthesis to regulate telomere length. Aging Cell. 2018 08; 17(4):e12783.

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Human DNA polymerase a interacts with mismatch repair proteins MSH2 and MSH6. FEBS Lett. 2016 Dec; 590(23):4233-4241.

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DNA polymerase-a regulates the activation of type I interferons through cytosolic RNA:DNA synthesis. Nat Immunol. 2016 May; 17(5):495-504.

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Processive Incorporation of Deoxynucleoside Triphosphate Analogs by Single-Molecule DNA Polymerase I (Klenow Fragment) Nanocircuits. J Am Chem Soc. 2015 Aug 05; 137(30):9587-94.

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Lagging-strand replication shapes the mutational landscape of the genome. Nature. 2015 Feb 26; 518(7540):502-506.

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Visualizing protein-DNA interactions in live bacterial cells using photoactivated single-molecule tracking. J Vis Exp. 2014 Mar 10; (85).

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Functional characterization of human CTC1 mutations reveals novel mechanisms responsible for the pathogenesis of the telomere disease Coats plus. Aging Cell. 2013 Dec; 12(6):1100-9.

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Carcinogenic adducts induce distinct DNA polymerase binding orientations. Nucleic Acids Res. 2013 Sep; 41(16):7843-53.

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Electronic measurements of single-molecule processing by DNA polymerase I (Klenow fragment). J Am Chem Soc. 2013 May 29; 135(21):7855-60.

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PolA1, a putative DNA polymerase I, is coexpressed with PerR and contributes to peroxide stress defenses of group A Streptococcus. J Bacteriol. 2013 Feb; 195(4):717-25.

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