"Acetate-CoA Ligase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the formation of CoA derivatives from ATP, acetate, and CoA to form AMP, pyrophosphate, and acetyl CoA. It acts also on propionates and acrylates. EC 6.2.1.1.
Concept/Terms
Acetate-CoA Ligase- Acetate-CoA Ligase
- Acetate CoA Ligase
- Ligase, Acetate-CoA
- Acetothiokinase
- Acetyl CoA Synthetase
- CoA Synthetase, Acetyl
- Synthetase, Acetyl CoA
- Acetyl Coenzyme A Synthetase
- Acetate Thiokinase
- Thiokinase, Acetate
- Acetyl Activating Enzyme
- Activating Enzyme, Acetyl
- Enzyme, Acetyl Activating
Below are MeSH descriptors whose meaning is more general than "Acetate-CoA Ligase".
Below are MeSH descriptors whose meaning is more specific than "Acetate-CoA Ligase".
This graph shows the total number of publications written about "Acetate-CoA Ligase" by people in Harvard Catalyst Profiles by year, and whether "Acetate-CoA Ligase" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 1 | 0 | 1 |
| 2009 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2017 | 1 | 0 | 1 |
| 2019 | 0 | 1 | 1 |
| 2021 | 1 | 0 | 1 |
| 2022 | 0 | 1 | 1 |
Below are the most recent publications written about "Acetate-CoA Ligase" by people in Profiles.
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O-GlcNAc transferase regulates glioblastoma acetate metabolism via regulation of CDK5-dependent ACSS2 phosphorylation. Oncogene. 2022 04; 41(14):2122-2136.
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Chemogenomics identifies acetyl-coenzyme A synthetase as a target for malaria treatment and prevention. Cell Chem Biol. 2022 02 17; 29(2):191-201.e8.
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mTORC2-AKT signaling to ATP-citrate lyase drives brown adipogenesis and de novo lipogenesis. Nat Commun. 2020 Jan 29; 11(1):575.
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Mitochondrial acetyl-CoA reversibly regulates locus-specific histone acetylation and gene expression. Life Sci Alliance. 2019 02; 2(1).
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ACSS2 gene variant associated with cleft lip and palate in two independent Hispanic populations. Laryngoscope. 2017 10; 127(10):E336-E339.
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Kinetic flux profiling elucidates two independent acetyl-CoA biosynthetic pathways in Plasmodium falciparum. J Biol Chem. 2013 Dec 20; 288(51):36338-50.
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ATP-citrate lyase links cellular metabolism to histone acetylation. Science. 2009 May 22; 324(5930):1076-80.
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Conserved metabolic regulatory functions of sirtuins. Cell Metab. 2008 Feb; 7(2):104-12.
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Sirtuins: a conserved key unlocking AceCS activity. Trends Biochem Sci. 2007 Jan; 32(1):1-4.
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Nucleocytosolic acetyl-coenzyme a synthetase is required for histone acetylation and global transcription. Mol Cell. 2006 Jul 21; 23(2):207-17.