Saxitoxin

"Saxitoxin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A compound that contains a reduced purine ring system but is not biosynthetically related to the purine alkaloids. It is a poison found in certain edible mollusks at certain times; elaborated by GONYAULAX and consumed by mollusks, fishes, etc. without ill effects. It is neurotoxic and causes RESPIRATORY PARALYSIS and other effects in MAMMALS, known as paralytic SHELLFISH poisoning.

Descriptor ID

D012530

MeSH Number(s)

D03.438.759.794

D23.946.580.830

Concept/Terms

Saxitoxin

Below are MeSH descriptors whose meaning is more general than "Saxitoxin".

Chemicals and Drugs [D]
Heterocyclic Compounds [D03]
Heterocyclic Compounds, 2-Ring [D03.438]
Purines [D03.438.759]
Saxitoxin [D03.438.759.794]
Biological Factors [D23]
Toxins, Biological [D23.946]
Marine Toxins [D23.946.580]
Saxitoxin [D23.946.580.830]

Below are MeSH descriptors whose meaning is related to "Saxitoxin".

Below are MeSH descriptors whose meaning is more specific than "Saxitoxin".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Saxitoxin" by people in Harvard Catalyst Profiles by year, and whether "Saxitoxin" was a major or minor topic of these publication.

Bar chart showing 15 publications over 11 distinct years, with a maximum of 4 publications in 2015

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1995	1	0	1
1997	0	1	1
2000	1	0	1
2004	0	1	1
2005	0	1	1
2007	1	0	1
2011	1	0	1
2012	1	1	2
2015	4	0	4
2016	1	0	1
2018	1	0	1

Below are the most recent publications written about "Saxitoxin" by people in Profiles.

Chemistry of a Unique Polyketide-like Synthase. J Am Chem Soc. 2018 02 21; 140(7):2430-2433.

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Measurement of neosaxitoxin in human plasma using liquid-chromatography tandem mass spectrometry: Proof of concept for a pharmacokinetic application. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Nov 15; 1036-1037:42-49.

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Neosaxitoxin versus Traditional Local Anesthetics: Mechanism of Action and Sites of Notable Effect. Anesthesiology. 2015 Oct; 123(4):A23.

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Neosaxitoxin in Rat Sciatic Block: Improved Therapeutic Index Using Combinations with Bupivacaine, with and without Epinephrine. Anesthesiology. 2015 Oct; 123(4):886-98.

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A Phase 1, Dose-escalation, Double-blind, Block-randomized, Controlled Trial of Safety and Efficacy of Neosaxitoxin Alone and in Combination with 0.2% Bupivacaine, with and without Epinephrine, for Cutaneous Anesthesia. Anesthesiology. 2015 Oct; 123(4):873-85.

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Corneal Anesthesia With Site 1 Sodium Channel Blockers and Dexmedetomidine. Invest Ophthalmol Vis Sci. 2015 Jun; 56(6):3820-6.

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Saxitoxins induce cytotoxicity, genotoxicity and oxidative stress in teleost neurons in vitro. Toxicon. 2014 Aug; 86:8-15.

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Prolonged nerve blockade delays the onset of neuropathic pain. Proc Natl Acad Sci U S A. 2012 Oct 23; 109(43):17555-60.

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Developing improved immunoassays for paralytic shellfish toxins: the need for multiple, superior antibodies. Talanta. 2012 Sep 15; 99:668-76.

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Respiratory, neuromuscular, and cardiovascular effects of neosaxitoxin in isoflurane-anesthetized sheep. Reg Anesth Pain Med. 2012 Mar-Apr; 37(2):152-8.

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