Paralysis, Hyperkalemic Periodic
"Paralysis, Hyperkalemic Periodic" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An autosomal dominant familial disorder which presents in infancy or childhood and is characterized by episodes of weakness associated with hyperkalemia. During attacks, muscles of the lower extremities are initially affected, followed by the lower trunk and arms. Episodes last from 15-60 minutes and typically occur after a period of rest following exercise. A defect in skeletal muscle sodium channels has been identified as the cause of this condition. Normokalemic periodic paralysis is a closely related disorder marked by a lack of alterations in potassium levels during attacks of weakness. (Adams et al., Principles of Neurology, 6th ed, p1481)
MeSH Number(s)
C05.651.701.600
C10.668.491.650.600
C16.320.565.618.711.600
C18.452.648.618.711.600
Concept/Terms
Paralysis, Hyperkalemic Periodic- Paralysis, Hyperkalemic Periodic
- Hyperkalemic Periodic Paralyses
- Paralyses, Hyperkalemic Periodic
- Periodic Paralyses, Hyperkalemic
- Periodic Paralysis, Hyperkalemic
- Familial Hyperkalemic Periodic Paralysis
- Hyperkalemic Periodic Paralysis
- Primary Hyperkalemic Periodic Paralysis
- Myotonic Periodic Paralysis
- Myotonic Periodic Paralyses
- Paralyses, Myotonic Periodic
- Paralysis, Myotonic Periodic
- Periodic Paralyses, Myotonic
- Periodic Paralysis, Myotonic
- Paralysis, Periodic, Hyperkalemic, Familial
- Periodic Paralysis - Hypokalemic
- Adynamia Episodica Hereditaria
- Hyperkalemic Periodic Paralysis, Familial
Below are MeSH descriptors whose meaning is more general than "Paralysis, Hyperkalemic Periodic".
- Diseases [C]
- Musculoskeletal Diseases [C05]
- Muscular Diseases [C05.651]
- Paralyses, Familial Periodic [C05.651.701]
- Paralysis, Hyperkalemic Periodic [C05.651.701.600]
- Nervous System Diseases [C10]
- Neuromuscular Diseases [C10.668]
- Muscular Diseases [C10.668.491]
- Paralyses, Familial Periodic [C10.668.491.650]
- Paralysis, Hyperkalemic Periodic [C10.668.491.650.600]
- Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]
- Genetic Diseases, Inborn [C16.320]
- Metabolism, Inborn Errors [C16.320.565]
- Metal Metabolism, Inborn Errors [C16.320.565.618]
- Paralyses, Familial Periodic [C16.320.565.618.711]
- Paralysis, Hyperkalemic Periodic [C16.320.565.618.711.600]
- Nutritional and Metabolic Diseases [C18]
- Metabolic Diseases [C18.452]
- Metabolism, Inborn Errors [C18.452.648]
- Metal Metabolism, Inborn Errors [C18.452.648.618]
- Paralyses, Familial Periodic [C18.452.648.618.711]
- Paralysis, Hyperkalemic Periodic [C18.452.648.618.711.600]
Below are MeSH descriptors whose meaning is more specific than "Paralysis, Hyperkalemic Periodic".
This graph shows the total number of publications written about "Paralysis, Hyperkalemic Periodic" by people in Harvard Catalyst Profiles by year, and whether "Paralysis, Hyperkalemic Periodic" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2008 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2017 | 0 | 1 | 1 |
Below are the most recent publications written about "Paralysis, Hyperkalemic Periodic" by people in Profiles.
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Spectrum of Nondystrophic Skeletal Muscle Channelopathies in Children. Pediatr Neurol. 2017 05; 70:26-33.
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Voltage-sensor movements describe slow inactivation of voltage-gated sodium channels II: a periodic paralysis mutation in Na(V)1.4 (L689I). J Gen Physiol. 2013 Mar; 141(3):323-34.
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Case records of the Massachusetts General Hospital. Case 4-2012. A 37-year-old man with muscle pain, weakness, and weight loss. N Engl J Med. 2012 Feb 09; 366(6):553-60.
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Targeted mutation of mouse skeletal muscle sodium channel produces myotonia and potassium-sensitive weakness. J Clin Invest. 2008 Apr; 118(4):1437-49.