Staurosporine

"Staurosporine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

An indolocarbazole that is a potent PROTEIN KINASE C inhibitor which enhances cAMP-mediated responses in human neuroblastoma cells. (Biochem Biophys Res Commun 1995;214(3):1114-20)

Descriptor ID

D019311

MeSH Number(s)

D03.132.436.750

D03.438.473.144.750

D03.438.473.402.750

D03.494.148.750

Concept/Terms

Staurosporine

Below are MeSH descriptors whose meaning is more general than "Staurosporine".

Chemicals and Drugs [D]
Heterocyclic Compounds [D03]
Alkaloids [D03.132]
Indole Alkaloids [D03.132.436]
Staurosporine [D03.132.436.750]
Heterocyclic Compounds, 2-Ring [D03.438]
Indoles [D03.438.473]
Carbazoles [D03.438.473.144]
Staurosporine [D03.438.473.144.750]
Indole Alkaloids [D03.438.473.402]
Staurosporine [D03.438.473.402.750]
Heterocyclic Compounds, 3-Ring [D03.494]
Carbazoles [D03.494.148]
Staurosporine [D03.494.148.750]

Below are MeSH descriptors whose meaning is related to "Staurosporine".

Below are MeSH descriptors whose meaning is more specific than "Staurosporine".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Staurosporine" by people in Harvard Catalyst Profiles by year, and whether "Staurosporine" was a major or minor topic of these publication.

Bar chart showing 135 publications over 29 distinct years, with a maximum of 9 publications in 2004

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1994	0	3	3
1995	0	5	5
1996	1	5	6
1997	0	4	4
1998	0	5	5
1999	1	5	6
2000	0	5	5
2001	0	4	4
2002	1	5	6
2003	4	3	7
2004	6	3	9
2005	4	4	8
2006	1	1	2
2007	2	4	6
2008	0	6	6
2009	1	4	5
2010	3	5	8
2011	0	3	3
2012	2	3	5
2013	1	1	2
2014	1	2	3
2015	0	2	2
2016	0	1	1
2017	6	1	7
2018	2	4	6
2019	2	2	4
2020	1	2	3
2021	2	1	3
2022	0	1	1

Below are the most recent publications written about "Staurosporine" by people in Profiles.

Treatment with midostaurin and other FLT3 targeting inhibitors is associated with an increased risk of cardiovascular adverse events in patients who underwent allogeneic hematopoietic stem cell transplantation with FLT3-mutated AML. Ann Hematol. 2023 Oct; 102(10):2903-2908.

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Midostaurin plus intensive chemotherapy for younger and older patients with AML and FLT3 internal tandem duplications. Blood Adv. 2022 09 27; 6(18):5345-5355.

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Clonal evolution of acute myeloid leukemia with FLT3-ITD mutation under treatment with midostaurin. Blood. 2021 06 03; 137(22):3093-3104.

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Post-transplantation maintenance with sorafenib or midostaurin for FLT3 positive AML patients - a multicenter retrospective observational study. Leuk Lymphoma. 2021 10; 62(10):2475-2481.

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Midostaurin reduces relapse in FLT3-mutant acute myeloid leukemia: the Alliance CALGB 10603/RATIFY trial. Leukemia. 2021 09; 35(9):2539-2551.

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Midostaurin in patients with acute myeloid leukemia and FLT3-TKD mutations: a subanalysis from the RATIFY trial. Blood Adv. 2020 10 13; 4(19):4945-4954.

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Effects of the multi-kinase inhibitor midostaurin in combination with chemotherapy in models of acute myeloid leukaemia. J Cell Mol Med. 2020 03; 24(5):2968-2980.

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The combination of FLT3 and SYK kinase inhibitors is toxic to leukaemia cells with CBL mutations. J Cell Mol Med. 2020 02; 24(3):2145-2156.

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Extracellular HtrA2 Induces Apoptosis in Human Umbilical Vein Endothelial Cells. Int J Mol Sci. 2019 Oct 31; 20(21).

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Acute Myeloid Leukemia: A New Era of Therapies, a New Wave of Toxicities? Acta Haematol. 2020; 143(1):5-6.

View in: PubMed

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