DNA Topoisomerases

"DNA Topoisomerases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Enzymes that regulate the topology of DNA by actions such as breaking, relaxing, passing, and rejoining strands of DNA in cells. These enzymes are important components of the DNA replication system. They are classified by their substrate specificities. DNA TOPOISOMERASE I enzymes act on a single strand of DNA. DNA TOPOISOMERASE II enzymes act on double strands of DNA.

Descriptor ID

D026942

MeSH Number(s)

D08.811.399.403

Concept/Terms

DNA Topoisomerases

Below are MeSH descriptors whose meaning is more general than "DNA Topoisomerases".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Isomerases [D08.811.399]
DNA Topoisomerases [D08.811.399.403]

Below are MeSH descriptors whose meaning is related to "DNA Topoisomerases".

Below are MeSH descriptors whose meaning is more specific than "DNA Topoisomerases".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "DNA Topoisomerases" by people in Harvard Catalyst Profiles by year, and whether "DNA Topoisomerases" was a major or minor topic of these publication.

Bar chart showing 4 publications over 4 distinct years, with a maximum of 1 publications in 2003 and 2019 and 2021 and 2022

To see the data from this visualization as text, click here.

Year	Major Topic	Total
2003	1	1
2019	1	1
2021	1	1
2022	1	1

Below are the most recent publications written about "DNA Topoisomerases" by people in Profiles.

Emerging roles of DNA topoisomerases in the regulation of R-loops. Mutat Res Genet Toxicol Environ Mutagen. 2022 Apr-May; 876-877:503450.

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Comprehensive expressional analysis of chemosensitivity-related markers in large cell neuroendocrine carcinoma of the lung. Thorac Cancer. 2021 10; 12(20):2666-2679.

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Fork pausing complex engages topoisomerases at the replisome. Genes Dev. 2020 01 01; 34(1-2):87-98.

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Mitigating Antagonism between Transcription and Proliferation Allows Near-Deterministic Cellular Reprogramming. Cell Stem Cell. 2019 10 03; 25(4):486-500.e9.

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HLA Class I and II Blocks Are Associated to Susceptibility, Clinical Subtypes and Autoantibodies in Mexican Systemic Sclerosis (SSc) Patients. PLoS One. 2015; 10(5):e0126727.

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Effect of nitric oxide on the anticancer activity of the topoisomerase-active drugs etoposide and adriamycin in human melanoma cells. J Pharmacol Exp Ther. 2013 Dec; 347(3):607-14.

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Topoisomerase inhibitors modulate expression of melanocytic antigens and enhance T cell recognition of tumor cells. Cancer Immunol Immunother. 2011 Jan; 60(1):133-44.

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In vivo selection during ofloxacin therapy of Escherichia coli with combined topoisomerase mutations that confer high resistance to ofloxacin but susceptibility to nalidixic acid. J Antimicrob Chemother. 2006 Nov; 58(5):1054-7.

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Increasing incidence of quinolone resistance in human non-typhoid Salmonella enterica isolates in Korea and mechanisms involved in quinolone resistance. J Antimicrob Chemother. 2005 Dec; 56(6):1111-4.

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Topoisomerase targeting with and resistance to gemifloxacin in Staphylococcus aureus. Antimicrob Agents Chemother. 2003 Jan; 47(1):274-82.

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J Antimicrob Chemother
Thorac Cancer
Mutat Res Genet Toxicol Environ Mutagen
J Pharmacol Exp Ther
Genes Dev
Antimicrob Agents Chemother
PLoS One
Cell Stem Cell
Cancer Immunol Immunother